Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Simon H. Friedman"'
Autor:
Rawle Francis, Simon H. Friedman
Publikováno v:
BioTechniques, Vol 32, Iss 5, Pp 1154-1160 (2002)
We have developed a high-throughput direct assay method for the assay of telomerase activity that improves on previous direct telomerase assays in two ways that allow larger numbers of samples to be conveniently processed: (i) 96-well streptavidin co
Externí odkaz:
https://doaj.org/article/7400c58a3a10486e99afc60afc70cd5c
Autor:
Swetha Chintala, Simon H. Friedman
Publikováno v:
ACS Biomater Sci Eng
In this work, we have brought the release of glucagon under the control of light. The aim of this approach is to allow minimally invasive, two-hormone control of blood glucose. Glucagon has two major challenges associated with its therapeutic applica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b5ecc4f14f54db16efdb3708af203b4
https://doi.org/10.1021/acsbiomaterials.1c00031
https://doi.org/10.1021/acsbiomaterials.1c00031
Autor:
Simon H. Friedman, Mayank Sharma
Publikováno v:
ChemPhotoChem. 5:611-618
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fe853c189be911ab076b12493ea8a73
https://doi.org/10.1002/cptc.202100001
https://doi.org/10.1002/cptc.202100001
Publikováno v:
Molecular Pharmaceutics. 16:4677-4687
In this work we describe the synthesis, characterization and ultimate in-vivo assessment of second generation insulin photoactivated depot (PAD) materials. These are the first to use visible light to stimulate insulin release, and have in-vivo perfor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edf9d00ee3c872846d9851479de23fb8
https://doi.org/10.1021/acs.molpharmaceut.9b00806
https://doi.org/10.1021/acs.molpharmaceut.9b00806
Publikováno v:
Molecular Pharmaceutics. 16:2922-2928
We have previously described the photoactivated depot (PAD) approach for the light-stimulated release of therapeutic proteins such as insulin. The aim of this method is to release insulin from a shallow dermal depot in response to blood glucose infor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd6704d084717c6078fd60d4bf665c91
https://doi.org/10.1021/acs.molpharmaceut.9b00140
https://doi.org/10.1021/acs.molpharmaceut.9b00140
Autor:
Simon H. Friedman, Nitin Jain
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:424-429
In this work we have developed specific inhibitors of HIV-1 reverse transcriptase by targeting the RNA/DNA duplex that is a principal substrate of the enzyme. To accomplish this, we have developed what we are calling the “weak intercalator” appro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3caeb764ea72f8a082d7da5a042a6fa6
https://doi.org/10.1016/j.bmcl.2018.12.027
https://doi.org/10.1016/j.bmcl.2018.12.027
Autor:
Mayank Sharma, Simon H. Friedman
Publikováno v:
ChemPhotoChem. 5:592-592
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b9d7e976e8dabf5e1cfceea9ba80489
https://doi.org/10.1002/cptc.202100135
https://doi.org/10.1002/cptc.202100135
Autor:
Nitin Jain, Simon H. Friedman
Publikováno v:
International Journal of Peptide Research and Therapeutics
We have developed a straightforward and robust strategy for synthesizing a family of cyclic peptide scaffolds for the presentation of defined moieties in a wide range of orientations. Specifically we are exploring quinoxaline as the moiety, as a pote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::600919a0bd68b669c850a0dd0a348312
https://doi.org/10.1007/s10989-017-9642-0
https://doi.org/10.1007/s10989-017-9642-0
Autor:
Simon H. Friedman
Publikováno v:
Current Diabetes Reports. 19
PURPOSE OF REVIEW: The aim of this review is to summarize the development of the photoactivated depot (PAD) approach for the minimally invasive and continuously variable delivery of insulin. RECENT FINDINGS: Using an insulin PAD, we have demonstrated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dbe33b2bcec0800a0684a369a2c1a89
https://doi.org/10.1007/s11892-019-1233-3
https://doi.org/10.1007/s11892-019-1233-3
Publikováno v:
Methods in enzymology. 624
In this work we describe methods for synthesizing and incorporating a wide range of photocleavable groups into proteins. These are based on the di-methoxyl nitro phenyl ethyl (DMNPE) group. Using a common ketone starting material, we have modified th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::337c9f838186344fab23d906cd2b4e05
https://pubmed.ncbi.nlm.nih.gov/31370926
https://pubmed.ncbi.nlm.nih.gov/31370926