Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Simon Guile"'
Autor:
Mark C. Wenlock, Lilian Alcaraz, Dearg S. Brown, Niklas Blomberg, Simon Guile, Paul D. Leeson, Thomas Elebring, Michael J. Waring, Britt-Marie Swahn, Kamaldeep K. Chohan, Steve Swallow, Stephen A. St-Gallay, Tim Luker, Andrew Griffin, Roger John Butlin
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:5673-5679
A valid PLS-DA model to predict attrition in pre-clinical toxicology for basic oral candidate drugs was built. A combination of aromatic/aliphatic balance, flatness, charge distribution and size descriptors helped predict the successful progression o
Autor:
Lilian Alcaraz, Timothy Nicholas Birkinshaw, Michael J. Stocks, Mark Ebden, Keith Bowers, Simon Guile, Mark Furber
Publikováno v:
Journal of Medicinal Chemistry. 52:3123-3141
Autor:
Rukhsana Tasneem Mohammed, Barrie Martin, David Donald, Simon Guile, Anthony Ingall, Andrew Wright, Cooper Martin, Richard J. Lewis, Reynolds Rachel Heulwen, John R. Bantick, Stephen A. St-Gallay, Eyssade Christine, Timothy J. Potter
Publikováno v:
Journal of Medicinal Chemistry. 50:254-263
We have previously described a novel series of potent blockers of the monocarboxylate transporter, MCT1, which show potent immunomodulatory activity in an assay measuring inhibition of PMA/ionomycin-induced human PBMC proliferation. However, the pref
Autor:
Cooper Martin, Clare Murray, Iain J. Martin, Reynolds Rachel Heulwen, Eyssade Christine, Anthony Ingall, Douglas Ferguson, Andrew M. Davis, Raymond Hutchinson, Evans Richard, David Donald, Phillip Thorne, Perry Matthew, Barrie Martin, John R. Bantick, Rukhsana Tasneem Mohammed, Stephen J. Hill, Simon Guile, Lee P. Kingston, David Cheshire, Jane Withnall, David J. Wilkinson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:2260-2265
A novel series of potent blockers of the monocarboxylate transporter, MCT1, is disclosed. From very potent but lipophilic lead compounds, systematic changes to all parts of the molecule, targeting reduction in log D, afforded compounds with significa
Publikováno v:
Angewandte Chemie International Edition in English. 35:1569-1572
Publikováno v:
ChemInform. 23
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ChemInform. 24
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ChemInform. 27
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ChemInform. 28
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ChemInform. 33
A concise approach to the cephalotaxine CDE ring skeleton based on the intramolecular formal [5 + 2] photocycloaddition of cyclopentenyl-substituted maleimides is described. An investigation of the diastereoselectivity afforded by various protected a