Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Simon Girard"'
Autor:
Oleksandr Olifir, Claudia Moreau, Maxime Cadieux-Dion, Berge Minassian, Patrick Cossette, Simon Girard
Publikováno v:
Genetics in Medicine Open, Vol 2, Iss , Pp 101513- (2024)
Externí odkaz:
https://doaj.org/article/daeca715cf1a4efcbbb8c9243f3fc41b
Autor:
Ciarán Campbell, Costin Leu, Yen-Chen Anne Feng, Stefan Wolking, Claudia Moreau, Colin Ellis, Shiva Ganesan, Helena Martins, Karen Oliver, Isabelle Boothman, Katherine Benson, Anne Molloy, Lawrence Brody, Jacques L. Michaud, Fadi F. Hamdan, Berge A. Minassian, Holger Lerche, Ingrid E. Scheffer, Sanjay Sisodiya, Simon Girard, Patrick Cosette, Norman Delanty, Dennis Lal, Gianpiero L. Cavalleri
Publikováno v:
EBioMedicine, Vol 81, Iss , Pp 104098- (2022)
Summary: Background: The developmental and epileptic encephalopathies (DEEs) are the most severe group of epilepsies which co-present with developmental delay and intellectual disability (ID). DEEs usually occur in people without a family history of
Externí odkaz:
https://doaj.org/article/533a6eda95d24053b4f85652d7d21d32
Autor:
Jalila Chagraoui, Bernhard Lehnertz, Simon Girard, Jean Francois Spinella, Iman Fares, Elisa Tomellini, Nadine Mayotte, Sophie Corneau, Tara MacRae, Laura Simon, Guy Sauvageau
Publikováno v:
PLoS ONE, Vol 14, Iss 11, p e0224900 (2019)
Elucidation of the molecular cues required to balance adult stem cell self-renewal and differentiation is critical for advancing cellular therapies. Herein, we report that the hematopoietic stem cell (HSC) self-renewal agonist UM171 triggers a balanc
Externí odkaz:
https://doaj.org/article/25a9012ffe7940d3b0c613d52f396eaf
Autor:
David Grote, Céline Moison, Stéphanie Duhamel, Jalila Chagraoui, Simon Girard, Jay Yang, Nadine Mayotte, Yan Coulombe, Jean-Yves Masson, Grant W. Brown, Sylvain Meloche, Guy Sauvageau
Publikováno v:
Cell Reports, Vol 11, Iss 2, Pp 210-219 (2015)
It has been previously shown that the polycomb protein BMI1 and E4F1 interact physically and genetically in the hematopoietic system. Here, we report that E4f1 is essential for hematopoietic cell function and survival. E4f1 deletion induces acute bon
Externí odkaz:
https://doaj.org/article/eea3de97076c4935830fbd6b151f051f
Autor:
Marc-André Legault, Simon Girard, Louis-Philippe Lemieux Perreault, Guy A Rouleau, Marie-Pierre Dubé
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0122287 (2015)
The advent of high throughput sequencing methods breeds an important amount of technical challenges. Among those is the one raised by the discovery of copy-number variations (CNVs) using whole-genome sequencing data. CNVs are genomic structural varia
Externí odkaz:
https://doaj.org/article/18849601ca834178a0e0ef7e5ee49b9f
Autor:
Ferran Casals, Alan Hodgkinson, Julie Hussin, Youssef Idaghdour, Vanessa Bruat, Thibault de Maillard, Jean-Christophe Grenier, Elias Gbeha, Fadi F Hamdan, Simon Girard, Jean-François Spinella, Mathieu Larivière, Virginie Saillour, Jasmine Healy, Isabel Fernández, Daniel Sinnett, Jacques L Michaud, Guy A Rouleau, Elie Haddad, Françoise Le Deist, Philip Awadalla
Publikováno v:
PLoS Genetics, Vol 9, Iss 9, p e1003815 (2013)
Whole-exome or gene targeted resequencing in hundreds to thousands of individuals has shown that the majority of genetic variants are at low frequency in human populations. Rare variants are enriched for functional mutations and are expected to expla
Externí odkaz:
https://doaj.org/article/9cc47deb1ace4078a7e93a220fcc9d66
Autor:
Simon Fortier, Mélanie Bilodeau, Tara Macrae, Jean-Philippe Laverdure, Valeria Azcoitia, Simon Girard, Jalila Chagraoui, Nancy Ringuette, Josée Hébert, Jana Krosl, Nadine Mayotte, Guy Sauvageau
Publikováno v:
PLoS Genetics, Vol 6, Iss 12, p e1001241 (2010)
Understanding the function of important DNA elements in mammalian stem cell genomes would be enhanced by the availability of deletion collections in which segmental haploidies are precisely characterized. Using a modified Cre-loxP-based system, we no
Externí odkaz:
https://doaj.org/article/c2133da05f2146cfb7f4cceb5663d843
Akademický článek
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Autor:
Céline Moison, Deanne Gracias, Julie Schmitt, Simon Girard, Simon Fortier, Isabel Boivin, Jean-Francois Spinella, Tara Macrae, Rejean Ruel, Josee Hebert, Anne Marinier, Guy Sauvageau
Publikováno v:
Blood. 140:10680-10681
Autor:
Deanne Gracias, Céline Moison, Rodrigo Mendoza-Sanchez, Simon Fortier, Simon Girard, Jean-Francois Spinella, Tara Macrae, Bounkham Thavonekham, Rejean Ruel, Josee Hebert, Anne Marinier, Guy Sauvageau
Publikováno v:
Blood. 140:10684-10684