Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Simon Geissler"'
Publikováno v:
International Journal of Pharmaceutics: X, Vol 7, Iss , Pp 100256- (2024)
The field of pharmaceutical 3D printing is growing over the past year, with Spitam® as the first 3D printed dosage form on the market. Showing the suitability of a binder jetting process for dosage forms. Although the development of inks for pharmac
Externí odkaz:
https://doaj.org/article/37c1ef09e3024d5bac3622b6f091cf5e
Publikováno v:
Pharmaceutics, Vol 14, Iss 1, p 216 (2022)
The aim of this research was the production of low-dosed filaments via hot-melt extrusion (HME) with the model drug pramipexole for the treatment of Parkinson’s disease. The active pharmaceutical ingredient (API) and one of the polymers polyvinyl a
Externí odkaz:
https://doaj.org/article/ba152500a6f64e669a1d41e45dcaace3
Autor:
Gesine Gunkel-Grabole, Tristan Marquetant, Lena Hoffmann, Jörg Breitkreutz, Rebecca Chamberlain, Thomas Kipping, Stefan Klinken, Simon Geißler, Alessandro Elia, Malte Bogdahn, Dnyaneshwar Kapote, Fabian Loose, Hellen Windolf, Nadine Gottschalk, Karin Eggenreich, Tilmann Spitz, Julian Quodbach
3d printing is capable of providing dose individualization for pediatric medicines and translating the precision medicine approach into practical application. In pediatrics, dose individualization and preparation of small dosage forms is a requiremen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e561e1efe5540ee112f0752dbc6f0207
https://epb.bibl.th-koeln.de/frontdoor/index/index/docId/2134
https://epb.bibl.th-koeln.de/frontdoor/index/index/docId/2134
Publikováno v:
Molecular Pharmaceutics. 14:2177-2196
The transport of drugs across the blood-brain barrier is challenging. The use of peptide sequences derived from viruses with a central nervous system (CNS) tropism is one elegant option. A prominent example is the rabies virus glycopeptide-29 (RVG-29
Publikováno v:
International journal of pharmaceutics. 514(1)
Numerous examples exist in the literature for the use of maleimide-thiol-reactions in the area of functionalized nanoparticles. Although the hydrolysis tendency of maleimides is well-known, qualitative and quantitative information on the stability an
Publikováno v:
International journal of pharmaceutics. 497(1-2)
Functionalized phospholipids are indispensable materials for the design of targeted liposomes. Control over the quality and quantity of phospholipids is thereby key in the successful development and manufacture of such formulations. This was also the
Autor:
Markus Weigandt, Karsten Mäder, Uwe Haberkorn, Simon Geissler, Sandra Breyer, Walter Mier, Alexandra Hill
Publikováno v:
Journal of controlled release : official journal of the Controlled Release Society. 168(1)
In research and development sufficiently high and constant plasma levels of drug candidates are often requested, but simple solutions of hydrophobic drugs delivered from the commonly used micro-osmotic pumps cannot meet these demands. Nanosuspensions
Autor:
Markus Weigandt, Gwenaelle van Colen, Uwe Haberkorn, Senta Voss, Achim Goepferich, Tobias Miller, Simon Geissler, Walter Mier, Sandra Breyer
Publikováno v:
International journal of pharmaceutics. 445(1-2)
Based on the enhanced permeability and retention (EPR) effect, nanoparticles are believed to accumulate in tumors. In this conjunction, the stability of drug encapsulation is assumed to be sufficient. For clarification purposes, PEGylated poly-(d,l-l
Publikováno v:
Pharmaceutical research. 29(10)
Nanocrystals exhibit enhanced dissolution rates and can effectively increase the bioavailability of poorly water soluble drug substances. However, methods for in vitro characterization of dissolution are unavailable. The objective of this study was t
Autor:
Angelika Semmler, Walter Mier, Sandra Breyer, Uwe Haberkorn, Simon Geissler, Tobias Miller, Alexandra Hill
Publikováno v:
International journal of pharmaceutics. 431(1-2)
Radiolabeling is a valuable option for tracking drug molecules in biodistribution experiments. In the development of innovative drug delivery systems the influence of the pharmaceutical formulation on the drugs' pharmacokinetics has to be investigate