Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Simon Gayton"'
Autor:
Simon Gayton, Graham Smith, Dafydd R. Owen, Gareth W. Harbottle, Tracy J. Ringer, Maw Graham Nigel, Simon A. Osborne, Margarita Rodriguez-Lens, Huw Rees, Peter G. Dodd, Ben S. Greener, Simon John Mantell
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:486-490
A series of novel mGluR1 antagonists have been prepared. Incorporation of fragments derived from weak lead matter into a library led to enhanced potency in a new chemical series. A chemistry driven second library iteration, covering a greatly enhance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9542eb7964fd6a3b5aa1b6c9a6e4b0a
https://doi.org/10.1016/j.bmcl.2006.10.015
https://doi.org/10.1016/j.bmcl.2006.10.015
Autor:
Simon Gayton, Andrew N. Warren, Blanda Luzia Christa Stammen, Matthew D. Selby, Jens Ahman, Sarah Haycock-Lewandowski, David Price
Publikováno v:
Tetrahedron Letters. 46:5005-5007
The initial synthesis of UK-427,857 (Maraviroc) is described including the preparation of 4,4-difluorocyclohexanoic acid and amide coupling utilizing a polymer supported reagent.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78b432b44ca8af7eae37bcab0631e83e
https://doi.org/10.1016/j.tetlet.2005.05.082
https://doi.org/10.1016/j.tetlet.2005.05.082
Publikováno v:
Synlett. 2002:1170-1172
A functionalisation of 1,3-diones using hypervalent iodine has been developed that is useful in the preparation of libraries of heterocyclic compounds.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd0a8c1a168743c65c6545fed669444f
https://doi.org/10.1055/s-2002-32577
https://doi.org/10.1055/s-2002-32577
Publikováno v:
ChemInform. 36
A robust synthesis of 1,2,4-triazoles is disclosed with a particular focus on developing methodology capable of delivering gram quantities and minimising hazardous waste.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::375f2c99e6c6135e34ead2069254b222
https://doi.org/10.1002/chin.200542145
https://doi.org/10.1002/chin.200542145