Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Simon Gayton"'
Autor:
Simon Gayton, Graham Smith, Dafydd R. Owen, Gareth W. Harbottle, Tracy J. Ringer, Maw Graham Nigel, Simon A. Osborne, Margarita Rodriguez-Lens, Huw Rees, Peter G. Dodd, Ben S. Greener, Simon John Mantell
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:486-490
A series of novel mGluR1 antagonists have been prepared. Incorporation of fragments derived from weak lead matter into a library led to enhanced potency in a new chemical series. A chemistry driven second library iteration, covering a greatly enhance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9542eb7964fd6a3b5aa1b6c9a6e4b0a
https://doi.org/10.1016/j.bmcl.2006.10.015
https://doi.org/10.1016/j.bmcl.2006.10.015
Autor:
Simon Gayton, Andrew N. Warren, Blanda Luzia Christa Stammen, Matthew D. Selby, Jens Ahman, Sarah Haycock-Lewandowski, David Price
Publikováno v:
Tetrahedron Letters. 46:5005-5007
The initial synthesis of UK-427,857 (Maraviroc) is described including the preparation of 4,4-difluorocyclohexanoic acid and amide coupling utilizing a polymer supported reagent.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78b432b44ca8af7eae37bcab0631e83e
https://doi.org/10.1016/j.tetlet.2005.05.082
https://doi.org/10.1016/j.tetlet.2005.05.082
Publikováno v:
Synlett. 2002:1170-1172
A functionalisation of 1,3-diones using hypervalent iodine has been developed that is useful in the preparation of libraries of heterocyclic compounds.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd0a8c1a168743c65c6545fed669444f
https://doi.org/10.1055/s-2002-32577
https://doi.org/10.1055/s-2002-32577
Autor:
Charles E. Mowbray, Rob Webster, Simon Gayton, Anthony Wood, Manos Perros, Matthew D. Selby, Isabelle Tran, Romuald Corbau, Stupple Paul Anthony, Catherine Burt, David Price, Faye J. Quinton, Michael Hawes
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(20)
We prepared three discreet cohorts of potent non-nucleoside HIV reverse transcriptase inhibitors (NNRTIs) based on the recently reported 3-cyanophenoxypyrazole lead 3. Several of these compounds displayed very promising anti-HIV activity in vitro, sa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16cfe3504dce023c44ac6d7739b403a0
https://pubmed.ncbi.nlm.nih.gov/19748778
https://pubmed.ncbi.nlm.nih.gov/19748778
Publikováno v:
ChemInform. 36
A robust synthesis of 1,2,4-triazoles is disclosed with a particular focus on developing methodology capable of delivering gram quantities and minimising hazardous waste.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::375f2c99e6c6135e34ead2069254b222
https://doi.org/10.1002/chin.200542145
https://doi.org/10.1002/chin.200542145