Zobrazeno 1 - 10
of 184
pro vyhledávání: '"Simon G, Williams"'
Autor:
Fardad Soltani, David A. Jenkins, Amit Kaura, Joshua Bradley, Nicholas Black, John P. Farrant, Simon G. Williams, Abdulrahim Mulla, Benjamin Glampson, Jim Davies, Dimitri Papadimitriou, Kerrie Woods, Anoop D. Shah, Mark R. Thursz, Bryan Williams, Folkert W. Asselbergs, Erik K. Mayer, Christopher Herbert, Stuart Grant, Nick Curzen, Iain Squire, Thomas Johnson, Kevin O’Gallagher, Ajay M. Shah, Divaka Perera, Rajesh Kharbanda, Riyaz S. Patel, Keith M. Channon, Richard Lee, Niels Peek, Jamil Mayet, Christopher A. Miller
Publikováno v:
BMC Cardiovascular Disorders, Vol 24, Iss 1, Pp 1-10 (2024)
Abstract Background Heart failure (HF) with preserved or mildly reduced ejection fraction includes a heterogenous group of patients. Reclassification into distinct phenogroups to enable targeted interventions is a priority. This study aimed to identi
Externí odkaz:
https://doaj.org/article/7f7bb0fa6ce44cb6909bc25ffc0b83f6
Autor:
Fardad Soltani, Joshua Bradley, Antonio Bonandi, Nicholas Black, John P. Farrant, Adam Pailing, Christopher Orsborne, Simon G. Williams, Erik B. Schelbert, Susanna Dodd, Richard Williams, Niels Peek, Matthias Schmitt, Theresa McDonagh, Christopher A. Miller
Publikováno v:
ESC Heart Failure, Vol 11, Iss 2, Pp 1022-1029 (2024)
Abstract Aims Population‐wide, person‐level, linked electronic health record data are increasingly used to estimate epidemiology, guide resource allocation, and identify events in clinical trials. The accuracy of data from NHS Digital (now part o
Externí odkaz:
https://doaj.org/article/ced8044b24bf49e694093e92ebfb4d83
Autor:
Nicholas Black, Joshua Bradley, Erik B. Schelbert, Laura J. Bonnett, Gavin A. Lewis, Jakub Lagan, Christopher Orsborne, Pamela F. Brown, Fardad Soltani, Fredrika Fröjdh, Martin Ugander, Timothy C. Wong, Miho Fukui, Joao L. Cavalcante, Josephine H. Naish, Simon G. Williams, Theresa McDonagh, Matthias Schmitt, Christopher A. Miller
Publikováno v:
Journal of Cardiovascular Magnetic Resonance, Vol 26, Iss 2, Pp 101064- (2024)
ABSTRACT: Background: Heart failure (HF) most commonly occurs in patients who have had a myocardial infarction (MI), but factors other than MI size may be deterministic. Fibrosis of myocardium remote from the MI is associated with adverse remodeling.
Externí odkaz:
https://doaj.org/article/b08b5a772f95418a8260330ed6636590
Autor:
Darren M Ashcroft, Bernard D Keavney, Hui Guo, Matthew J Carr, Simon Frain, Simon G. Williams
Publikováno v:
Open Heart, Vol 10, Iss 2 (2023)
Objective To determine the magnitude of any excess risk of mortality and hospitalisation due to COVID-19 infection in patients with congenital heart disease (CHD) in the UK healthcare system.Methods Matched case–control study within the Clinical Pr
Externí odkaz:
https://doaj.org/article/fa0edb56167043c59d1a6735794382f7
Autor:
Dominic J. F. Byrne, Simon G. Williams, Apostol Nakev, Simon Frain, Stephanie L. Baross, Jørgen Vestbo, Bernard D. Keavney, David Talavera
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract Adults with congenital heart disease (CHD) face increased risk of various comorbid diseases. Previous work on lung dysfunction in this population has mainly focused on restrictive lung disease, in patients with severe CHD phenotypes. We exam
Externí odkaz:
https://doaj.org/article/79a54d4306a540fe91516c9299caea65
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract The genome-wide promoter interactome is primarily maintained and regulated by architectural proteins such as CTCF and cohesin. However, some studies suggest a role for non-coding RNAs (ncRNAs) in this process. We aimed to characterise the re
Externí odkaz:
https://doaj.org/article/e549fe2048b642deb926b19e627cea3f
Autor:
Gavin A. Lewis, Anna Rosala‐Hallas, Susanna Dodd, Erik B. Schelbert, Simon G. Williams, Colin Cunnington, Theresa McDonagh, Christopher A. Miller
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 11, Iss 14 (2022)
Background Growth differentiation factor 15 (GDF‐15) is elevated in heart failure with preserved ejection fraction and is associated with adverse outcome, but its relationship with myocardial fibrosis and other characteristics remains unclear. We s
Externí odkaz:
https://doaj.org/article/4a9ca6e70bc444bca4f2df9be00422b2
Publikováno v:
Open Heart, Vol 7, Iss 1 (2020)
ObjectivesIron deficiency (ID), with or without anaemia (IDA), is an important comorbidity in people with chronic heart failure (HF), but the prevalence and significance in those admitted with HF is uncertain. We assessed the prevalence of ID or IDA
Externí odkaz:
https://doaj.org/article/93f100c7c1ef4a7ba1ee14283b15eced
Autor:
Mun-Kit Choy, Biola M. Javierre, Simon G. Williams, Stephanie L. Baross, Yingjuan Liu, Steven W. Wingett, Artur Akbarov, Chris Wallace, Paula Freire-Pritchett, Peter J. Rugg-Gunn, Mikhail Spivakov, Peter Fraser, Bernard D. Keavney
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Human embryonic stem cell-derived cardiomyocytes (hESC-CM) are a widely used model to study cardiac genomics. Here, Choy et al. perform promoter capture Hi-C to map long-range chromosomal interactions of hESC-CMs and to study overlap of such regions
Externí odkaz:
https://doaj.org/article/83ebcba231fa46148d8363dbe91cb2fe
Autor:
Gavin A. Lewis, Anna Rosala-Hallas, Susanna Dodd, Erik B. Schelbert, Simon G. Williams, Colin Cunnington, Theresa McDonagh, Christopher A. Miller
Publikováno v:
Journal of Cardiovascular Translational Research. 15:1436-1443
Purpose: Myocardial fibrosis, measured using cardiovascular magnetic resonance extracellular volume (ECV), is associated with adverse outcome in heart failure with preserved ejection fraction (HFpEF), but the mechanisms by which myocardial fibrosis e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcc42e15338b654bc784a07882e480a2
https://doi.org/10.1007/s12265-022-10264-7
https://doi.org/10.1007/s12265-022-10264-7