Výsledky vyhledávání - "Simon Fortier"

Akademický článek

Bicc1 ribonucleoprotein complexes specifying organ laterality are licensed by ANKS6-induced structural remodeling of associated ANKS3.

Autor: Benjamin Rothé, Yayoi Ikawa, Zhidian Zhang, Takanobu A Katoh, Eriko Kajikawa, Katsura Minegishi, Sai Xiaorei, Simon Fortier, Matteo Dal Peraro, Hiroshi Hamada, Daniel B Constam

Publikováno v: PLoS Biology, Vol 21, Iss 9, p e3002302 (2023)

Organ laterality of vertebrates is specified by accelerated asymmetric decay of Dand5 mRNA mediated by Bicaudal-C1 (Bicc1) on the left side, but whether binding of this or any other mRNA to Bicc1 can be regulated is unknown. Here, we found that a CRI

Externí odkaz: https://doaj.org/article/e4ddd114040a4c738aa6b08683c53627

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Akademický článek

Antagonistic interactions among structured domains in the multivalent Bicc1-ANKS3-ANKS6 protein network govern phase transitioning of target mRNAs

Autor: Benjamin Rothé, Simon Fortier, Céline Gagnieux, Céline Schmuziger, Daniel B. Constam

Publikováno v: iScience, Vol 26, Iss 6, Pp 106855- (2023)

Summary: The growing number of diseases linked to aberrant phase transitioning of ribonucleoproteins highlights the need to uncover how the interplay between multivalent protein and RNA interactions is regulated. Cytoplasmic granules of the RNA bindi

Externí odkaz: https://doaj.org/article/2db92b21cff24081a67fffefb22cbf89

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Akademický článek

Role of Bicaudal C1 in renal gluconeogenesis and its novel interaction with the CTLH complex.

Autor: Lucia Carolina Leal-Esteban, Benjamin Rothé, Simon Fortier, Manuela Isenschmid, Daniel B Constam

Publikováno v: PLoS Genetics, Vol 14, Iss 7, p e1007487 (2018)

Altered glucose and lipid metabolism fuel cystic growth in polycystic kidneys, but the cause of these perturbations is unclear. Renal cysts also associate with mutations in Bicaudal C1 (Bicc1) or in its self-polymerizing sterile alpha motif (SAM). He

Externí odkaz: https://doaj.org/article/409d128c75e34fdbbc166331a347294f

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Akademický článek

Necrosis Induction in Glioblastoma Cells Reveals a New 'Bioswitch' Function for the MT1-MMP/G6PT Signaling Axis in proMMP-2 Activation versus Cell Death Decision

Autor: Anissa Belkaid, Simon Fortier, Jian Cao, Borhane Annabi

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 9, Iss 4, Pp 332-340 (2007)

Cytoskeleton disorganization is an early step in the activation process of matrix metalloproteinase 2 (MMP-2) by membrane type 1 MMP (MTi-MMP) but is also associated with endoplasmic reticulum (ER) dysfunction and subsequent cell death. Given evidenc

Externí odkaz: https://doaj.org/article/dc45dd3baf544e438ca8c679daf83887

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Akademický článek

Genome-wide interrogation of Mammalian stem cell fate determinants by nested chromosome deletions.

Autor: Simon Fortier, Mélanie Bilodeau, Tara Macrae, Jean-Philippe Laverdure, Valeria Azcoitia, Simon Girard, Jalila Chagraoui, Nancy Ringuette, Josée Hébert, Jana Krosl, Nadine Mayotte, Guy Sauvageau

Publikováno v: PLoS Genetics, Vol 6, Iss 12, p e1001241 (2010)

Understanding the function of important DNA elements in mammalian stem cell genomes would be enhanced by the availability of deletion collections in which segmental haploidies are precisely characterized. Using a modified Cre-loxP-based system, we no

Externí odkaz: https://doaj.org/article/c2133da05f2146cfb7f4cceb5663d843

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