Small-Molecule 3D Ligand for RNA Recognition: Tuning Selectivity through Scaffold Hopping

Autor: Simon Felder, Corinne Sagné, Erica Benedetti, Laurent Micouin

Publikováno v: ACS chemical biology. 17(11)

Targeting RNAs with small molecules is considered the next frontier for drug discovery. In this context, the development of compounds capable of binding RNA structural motifs of low complexity with high affinity and selectivity would greatly expand t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4445f5a8f32b8d05579132eb82899b08
https://pubmed.ncbi.nlm.nih.gov/36314850

Para‐Functionalization of N‐Substituted 4‐amino[2.2]paracyclophanes by Regioselective Formylation

Autor: Laurent Micouin, Simon Felder, Erica Benedetti

Publikováno v: European Journal of Organic Chemistry
European Journal of Organic Chemistry, Wiley-VCH Verlag, 2021, pp.4015. ⟨10.1002/ejoc.202100288⟩

International audience

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b8e17a01726069bfa7a25210f30cb7c
https://doi.org/10.1002/ejoc.202100288

Planar Chiral Analogues of PRODAN Based on a [2.2]Paracyclophane Scaffold: Synthesis and Photophysical Studies

Autor: Simon Felder, Marie-Léonie Delcourt, Manon H. E. Bousquet, Denis Jacquemin, Rafael Rodríguez, Ludovic Favereau, Jeanne Crassous, Laurent Micouin, Erica Benedetti

Publikováno v: Journal of Organic Chemistry
Journal of Organic Chemistry, American Chemical Society, 2022, ⟨10.1021/acs.joc.1c02071⟩
Journal of Organic Chemistry, 2022, 87 (1), pp.147-158. ⟨10.1021/acs.joc.1c02071⟩

International audience; We describe the synthesis and photophysical characterization of differently substituted planar chiral analogues of PRODAN based on a [2.2]paracyclophane scaffold. This experimental and theoretical study highlights that the (ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f04bdabde080f818623cbc204f7a8f7
https://pubmed.ncbi.nlm.nih.gov/34908417

Highly Enantioselective Asymmetric Transfer Hydrogenation: A Practical and Scalable Method To Efficiently Access Planar Chiral [2.2]Paracyclophanes

Autor: Corina H. Pollok, Laurent Micouin, Simon Felder, Erica Benedetti, Serge Turcaud, Marie-Léonie Delcourt, Christian Merten

Publikováno v: Journal of Organic Chemistry
Journal of Organic Chemistry, American Chemical Society, 2019, ⟨10.1021/acs.joc.9b00372⟩

We report herein a general, practical method based on asymmetric transfer hydrogenation (ATH) to control the planar chirality of a range of substituted [2.2]paracyclophanes (pCps). Our strategy enabled us to perform both the kinetic resolution (KR) o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ced70a754f75ca06bbc04c8a08e2d97
https://hal.archives-ouvertes.fr/hal-02113386

Synthesis of deuterated C-6 and C-9 flavour volatiles

Autor: Daryl D. Rowan, Simon Felder

Publikováno v: Journal of Labelled Compounds and Radiopharmaceuticals. 42:83-92

Regiospecific deuterogenation of alkynols and chain extension of deuterated C-6 alkyl halides by alkylation with malondialdehyde derivatives was used to synthesise a series of deuterated C-6 and C-9 flavour volatiles. Reduction of 3-hexyn-1-ol with d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4fd351d6efe20ca5e7ba23986e8e485e
https://doi.org/10.1002/(sici)1099-1344(199901)42:1<83::aid-jlcr169>3.0.co