Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Simon F. Semus"'
Autor:
Xiaoping Xu, Earl Gordon, Robert N. Willette, Irina M. Lozinskaya, Zuojun Lin, Frank E. Blaney, Simon F. Semus
Publikováno v:
Molecular Pharmacology. 73:639-651
Long and short QT syndromes associated with loss and gain of human ether-a-go-go-related gene (hERG) channel activity, respectively, can cause life-threatening arrhythmias. As such, modulation of hERG channel activity is an important consideration in
Autor:
Alexander Rochester New York Us Kover, James T. Loch, L.Paul Rosenberg, Simon F. Semus, John Zongrone, Anthony C. Machulskis, James C. Blosser, John C. Gordon, Patrick R. Verhoest, Sally A. McCreedy, Edwin S. C. Wu
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:2525-2530
To improve receptor binding affinity and to investigate functional selectivity of 2,8-dimethyl-1-oxa-8-azaspiro[4.5]decan-3-one acetylhydrazone 2 at muscarinic receptor subtypes, a series of acylhydrazones A was synthesized. The SAR indicates that th
Autor:
Glen E. Kellogg, Simon F. Semus
Publikováno v:
Modern Methods of Drug Discovery ISBN: 9783034893978
The belief that there is a direct relationship between chemical structure and biological activity of therapeutic agents is fundamental to the field of medicinal chemistry. Indeed, the efforts of early medicinal chemists focused on well-defined struct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::464c95c7fa462ee25dd9988d5a39209f
https://doi.org/10.1007/978-3-0348-7997-2_11
https://doi.org/10.1007/978-3-0348-7997-2_11
Publikováno v:
Journal of medicinal chemistry. 41(22)
Autor:
Billy R. Martin, Alexandros Makriyannis, Gilbert Marciniak, Sonyuan Lin, Simon F. Semus, Jolanta Grzybowska, D R Compton, Avgui Charalambous
Publikováno v:
Pharmacology, biochemistry, and behavior. 46(2)
One aspect of cannabinoid structure-activity relationships (SARs) that has not been thoroughly investigated is the aromatic (A) ring. Although halogenation of the side chain enhances potency, our recent observation that iodination of the A ring also
A computergraphic investigation into the pharmacological role of the THC-cannabinoid phenolic moiety
Autor:
Simon F. Semus, Billy R. Martin
Publikováno v:
Life sciences. 46(24)
There has been much debate as to the nature of the cannabinoid-receptor interaction, whether by traditional interpretation or by means of membrane perturbation. Whichever hypothesis is correct, the structural requirements for pharmacological action n
Autor:
Clark A. Sehon, Gren Z. Wang, Andrew Q. Viet, Krista B. Goodman, Sarah E. Dowdell, Patricia A. Elkins, Simon F. Semus, Christopher Evans, Larry J. Jolivette, Robert B. Kirkpatrick, Edward Dul, Sanjay S. Khandekar, Tracey Yi, Lois L. Wright, Gary K. Smith, David J. Behm, Ross Bentley, Christopher P. Doe, Erding Hu, Dennis Lee
Publikováno v:
Journal of Medicinal Chemistry; Oct2008, Vol. 51 Issue 21, p6631-6634, 4p
Autor:
Krista B. Goodman, Haifeng Cui, Sarah E. Dowdell, Dimitri E. Gaitanopoulos, Robert L. Ivy, Clark A. Sehon, Robert A. Stavenger, Gren Z. Wang, Andrew Q. Viet, Weiwei Xu, Guosen Ye, Simon F. Semus, Christopher Evans, Harvey E. Fries, Larry J. Jolivette, Robert B. Kirkpatrick, Edward Dul, Sanjay S. Khandekar, Tracey Yi, David K. Jung
Publikováno v:
Journal of Medicinal Chemistry; Jan2007, Vol. 50 Issue 1, p6-9, 4p
Autor:
Robert A. Stavenger, Haifeng Cui, Sarah E. Dowdell, Robert G. Franz, Dimitri E. Gaitanopoulos, Krista B. Goodman, Mark A. Hilfiker, Robert L. Ivy, Jack D. Leber, Joseph P. Marino Jr., Hye-Ja Oh, Andrew Q. Viet, Weiwei Xu, Guosen Ye, Daohua Zhang, Yongdong Zhao, Larry J. Jolivette, Martha S. Head, Simon F. Semus, Patricia A. Elkins
Publikováno v:
Journal of Medicinal Chemistry; Jan2007, Vol. 50 Issue 1, p2-5, 4p