Výsledky vyhledávání - "Simon E. Alfred"

In Planta Labeling Using a Clickable ER-Disrupting Probe Suggests a Role for Oleosins in Arabidopsis Seedling ER Integrity

Autor: Sean R. Cutler, Aditya S. Vaidya, Wim Dejonghe, Simon E. Alfred

Publikováno v: ACS Chemical Biology. 16:2151-2157

Several small-molecule perturbagens of the plant endomembrane system are known, but few selectively disrupt endoplasmic reticulum (ER) structure and function. We conducted a microscopy-based screen for small-molecule disruptors of ER structure and di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8b981ea2bee2cc1b251a279094cfba60
https://doi.org/10.1021/acschembio.1c00607

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Akademický článek

MicroRNA dysregulation, gene networks and risk for schizophrenia in 22q11.2 deletion syndrome

Autor: Daniele eMerico, Gregory eCostain, Nancy eButcher, William eWarnica, Lucas eOgura, Simon E Alfred, Linda eBrzustowicz, Anne eBassett

Publikováno v: Frontiers in Neurology, Vol 5 (2014)

The role of microRNAs (miRNAs) in the aetiology of schizophrenia is increasingly recognized. Microdeletions at chromosome 22q11.2 are recurrent structural variants that impart a high risk for schizophrenia and are found in up to 1% of all patients wi

Externí odkaz: https://doaj.org/article/9225eba6ed9e462d9b68a9970bd9092d

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Incipient stem cell niche conversion in tissue culture: using a systems approach to probe early events inWUSCHEL-dependent conversion of lateral root primordia into shoot meristems

Autor: Nicholas J. Provart, Resmi Capron, Hardeep Nahal, Steven P. Chatfield, Pier-Andree Penttila, Andre Severino, Simon E. Alfred

Publikováno v: The Plant Journal. 73:798-813

SUMMARY Adventitious shoot organogenesis contributes to the fitness of diverse plant species, and control of this process is a vital step in plant transformation and in vitro propagation. New shoot meristems (SMs) can be induced by the conversion of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::560f32880ab60e7f9d5d6c2e75056d4b
https://doi.org/10.1111/tpj.12085

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Chemical genetic interrogation of natural variation uncovers a molecule that is glycoactivated

Autor: Rachel Puckrin, Simon E. Alfred, Tsz-fung Freeman Chow, Yang Zhao, Cynthia K. Larive, Albert K. Korir, Sean R. Cutler

Publikováno v: Nature Chemical Biology. 3:716-721

Natural variation in human drug metabolism and target genes can cause pharmacogenetic or interindividual variation in drug sensitivity. We reasoned that natural pharmacogenetic variation in model organisms could be systematically exploited to facilit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be7643eab53a6db8ad5a401a3ebba5a6
https://doi.org/10.1038/nchembio.2007.32

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Sequence variants within exon 1 ofMECP2 occur in females with mental retardation

Autor: Chris G, Harvey, Sailesh D, Menon, Beata, Stachowiak, Abdul, Noor, Adam, Proctor, Albert K, Mensah, Gevork N, Mnatzakanian, Simon E, Alfred, Ray, Guo, Stephen W, Scherer, James L, Kennedy, Wendy, Roberts, Anand K, Srivastava, Anand K, Srivistava, Berge A, Minassian, John B, Vincent

Publikováno v: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. :355-360

A new splice variant of the Rett syndrome gene, MECP2, was recently identified, that includes coding sequence from exon 1, and is the predominant transcript in the central nervous system. This sequence encodes polyalanine and polyglycine stretches wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f905245ffbe07f0b7c2902764015c6ac
https://doi.org/10.1002/ajmg.b.30425

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Copy number variable microRNAs in schizophrenia and their neurodevelopmental gene targets

Autor: John Wei, William Warnica, Gregory Costain, Anne S. Bassett, Daniele Merico, Stephen W. Scherer, Simon E. Alfred, Christian R. Marshall

Publikováno v: Biological psychiatry. 77(2)

MicroRNAs (miRNAs) are key regulators of gene expression in the human genome and may contribute to risk for neuropsychiatric disorders. miRNAs play an acknowledged role in the strongest of genetic risk factors for schizophrenia, 22q11.2 deletions. We

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78def22dd84835b6b03e1b5d771852b6
https://pubmed.ncbi.nlm.nih.gov/25524307

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A phenotypic screening platform to identify small molecule modulators of Chlamydomonas reinhardtii growth, motility and photosynthesis

Autor: Malene L. Urbanus, Guri Giaever, Simon E. Alfred, Alexander Mok, Anuradha Surendra, Ken Lin, Chris Le, Iain M. Wallace, Corey Nislow, Michael Proctor

Publikováno v: Genome Biology

Chemical biology, the interfacial discipline of using small molecules as probes to investigate biology, is a powerful approach of developing specific, rapidly acting tools that can be applied across organisms. The single-celled alga Chlamydomonas rei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::090b0f357d4a884d361c3d904c212cfb
https://pubmed.ncbi.nlm.nih.gov/23158586

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Abscisic acid inhibits PP2Cs via the PYR/PYL family of ABA-binding START proteins

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

ABA Receptor Rumbled? The plant hormone abscisic acid (ABA) is critical for normal development and for mediating plant responses to stressful environmental conditions. Now, two papers present analyses of candidate ABA receptors (see the news story by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7de67d34ea365095ba139be1ade85ae
https://europepmc.org/articles/PMC2827199/

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Characterization of a de novo translocation t(5;18)(q33.1;q12.1) in an autistic boy identifies a breakpoint close to SH3TC2, ADRB2, and HTR4 on 5q, and within the desmocollin gene cluster on 18q

Autor: John B. Vincent, Simon E. Alfred, Thomas Schwarzbraun, Klaus Wagner, Christian Windpassinger, Beata Stachowiak, Peter J. Gianakopoulos, Peter M. Kroisel, Stephen W. Scherer, Wendy Roberts, Abdul Noor, Erwin Petek

Publikováno v: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. (6)

We have recently reported the identification of a de novo balanced translocation t(5;18)(q33.1;q12.1) in a boy with autism. Here we discuss the identification of the breakpoints on chromosomes 5 and 18, and subsequent genomic and candidate gene analy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d893a7a2546efc332c6ea3a2182dd8e7
https://pubmed.ncbi.nlm.nih.gov/19086034

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