Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Simon E Richardson"'
Autor:
Hung-Chang Chen, Nico Mueller, Katherine Stott, Chrysa Kapeni, Eilidh Rivers, Carolin M Sauer, Flavio Beke, Stephen J Walsh, Nicola Ashman, Louise O’Brien, Amir Rafati Fard, Arman Ghodsinia, Changtai Li, Fadwa Joud, Olivier Giger, Inti Zlobec, Ioana Olan, Sarah J Aitken, Matthew Hoare, Richard Mair, Eva Serrao, James D Brenton, Alicia Garcia-Gimenez, Simon E Richardson, Brian Huntly, David R Spring, Mikkel-Ole Skjoedt, Karsten Skjødt, Marc de la Roche, Maike de la Roche
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 9, Pp 2233-2261 (2024)
Abstract We have developed and validated a highly specific, versatile antibody to the extracellular domain of human LGR5 (α-LGR5). α-LGR5 detects LGR5 overexpression in >90% of colorectal cancer (CRC), hepatocellular carcinoma (HCC) and pre-B-ALL t
Externí odkaz:
https://doaj.org/article/4df981d9b6cb481e9115536caaf2c410
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
B cell precursor acute lymphoblastic leukemia (BCP-ALL) is a malignant disorder of immature B lineage immune progenitors and is the commonest cancer in children. Despite treatment advances it remains a leading cause of death in childhood and response
Externí odkaz:
https://doaj.org/article/300e28d70e874686b1e12a2c1d2dc34a
Publikováno v:
iScience, Vol 25, Iss 12, Pp 105622- (2022)
Summary: Several studies have documented aberrant RNA editing patterns across multiple tumors across large patient cohorts from The Cancer Genome Atlas (TCGA). However, studies on understanding the role of RNA editing in acute myeloid leukemia (AML)
Externí odkaz:
https://doaj.org/article/0c7677ca02cc4eab950752ae31ce4cbc
Publikováno v:
HemaSphere, Vol 5, Iss 6, p e589 (2021)
Externí odkaz:
https://doaj.org/article/fdac97f49299421a9eba722f7c7307e1
In vitro differentiation of human pluripotent stem cells into the B lineage using OP9-MS5 co-culture
Publikováno v:
STAR Protocols, Vol 2, Iss 2, Pp 100420- (2021)
Summary: In vitro differentiation of human pluripotent stem cells (hPSCs) offers a genetically tractable system to examine the physiology and pathology of human tissue development and differentiation. We have used this approach to model the earliest
Externí odkaz:
https://doaj.org/article/a918438e9d6f4dd4af6e4015bae93202
Autor:
Simon E. Richardson, Duncan Brian, Victoria Grandage, Rachael Hough, Panagiotis Kottaridis, Marc R. Mansour, Elspeth M. Payne, Asim Khwaja
Publikováno v:
HemaSphere, Vol 3, Iss 1 (2019)
Externí odkaz:
https://doaj.org/article/7dbadbb6e16d43a69d79dce4016c47f0
Autor:
Marc R. Mansour, Robertus A.M. de Bruin, David C. Linch, Javier Herrero, Stephen Henderson, Elisabeth P. Nacheva, Rajeev Gupta, José Afonso Guerra-Assunção, Sara Ahrabi, Simon E. Richardson, Nadine Farah, Brian Philip, Michael Magnussen, Sunniyat Rahman, Cosetta Bertoli, Tanya Rapoz-D'Silva, Theresa E. León
Loss-of-function mutations of EZH2, the enzymatic component of PRC2, have been associated with poor outcome and chemotherapy resistance in T-cell acute lymphoblastic leukemia (T-ALL). Using isogenic T-ALL cells, with and without CRISPR/Cas9–induced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4089bdc0a61ebcf86d1dc460a116dd79
https://doi.org/10.1158/2159-8290.c.6547820.v1
https://doi.org/10.1158/2159-8290.c.6547820.v1
Autor:
Marc R. Mansour, Robertus A.M. de Bruin, David C. Linch, Javier Herrero, Stephen Henderson, Elisabeth P. Nacheva, Rajeev Gupta, José Afonso Guerra-Assunção, Sara Ahrabi, Simon E. Richardson, Nadine Farah, Brian Philip, Michael Magnussen, Sunniyat Rahman, Cosetta Bertoli, Tanya Rapoz-D'Silva, Theresa E. León
Supplementary Table 2: Cell viability data from the small-molecule drug screening in EZH2-WT and EZH2-KO1 cells (related to Fig. 1)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e26a77353001cee6173af99ff4ca604
https://doi.org/10.1158/2159-8290.22535303
https://doi.org/10.1158/2159-8290.22535303
Autor:
Marc R. Mansour, Robertus A.M. de Bruin, David C. Linch, Javier Herrero, Stephen Henderson, Elisabeth P. Nacheva, Rajeev Gupta, José Afonso Guerra-Assunção, Sara Ahrabi, Simon E. Richardson, Nadine Farah, Brian Philip, Michael Magnussen, Sunniyat Rahman, Cosetta Bertoli, Tanya Rapoz-D'Silva, Theresa E. León
Supplementary Table 3: Mutations identified by exome sequencing in Liu et al., 2017 T-ALL cohort (related to Fig. 5G)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25ea44d21ae7274a589b69661541a050
https://doi.org/10.1158/2159-8290.22535300.v1
https://doi.org/10.1158/2159-8290.22535300.v1
Autor:
Marc R. Mansour, Robertus A.M. de Bruin, David C. Linch, Javier Herrero, Stephen Henderson, Elisabeth P. Nacheva, Rajeev Gupta, José Afonso Guerra-Assunção, Sara Ahrabi, Simon E. Richardson, Nadine Farah, Brian Philip, Michael Magnussen, Sunniyat Rahman, Cosetta Bertoli, Tanya Rapoz-D'Silva, Theresa E. León
Supplementary Figures and Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bc9558b116cac1d0add91d3d2effc13
https://doi.org/10.1158/2159-8290.22535309.v1
https://doi.org/10.1158/2159-8290.22535309.v1