Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Simon Dewar"'
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 10, Iss 5, p e0004714 (2016)
Bifunctional dihydrofolate reductase-thymidylate synthase (DHFR-TS) is a chemically and genetically validated target in African trypanosomes, causative agents of sleeping sickness in humans and nagana in cattle. Here we report the kinetic properties
Externí odkaz:
https://doaj.org/article/79e36dfa8ce84c4388fc01bd0e26d301
Publikováno v:
Journal of Antimicrobial Chemotherapy. 77:1432-1435
Background There is in vitro and clinical evidence to suggest daptomycin has good activity against Enterococcus. In 2019, CLSI produced clinical breakpoints for Enterococcus spp. Objectives To describe the distribution of MICs of daptomycin for enter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f39288cf85802550e9da1c2e41cab58
https://doi.org/10.1093/jac/dkac042
https://doi.org/10.1093/jac/dkac042
Publikováno v:
Access Microbiology
Lawsonella clevelandensis is an anaerobic, partially acid-fast, Gram-positive bacillus associated with abscess formation. We present the case of a 70-year-old male with chronic contained rupture of abdominal aortic aneurysm (CCR-AAA) complicated by i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5e72c7625bde192e8033d36822a70aa
https://doi.org/10.1099/acmi.0.000183
https://doi.org/10.1099/acmi.0.000183
Publikováno v:
Journal of Antimicrobial Chemotherapy. 69:303-308
The continuing spread of resistant Gram-negative bacteria is a therapeutic challenge and prudent use of antimicrobials is therefore essential. Urinary tract infections (UTIs), usually due to Gram-negative bacteria, are among the most common infection
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56b09c2bac8b6a0ea615593b203cbcd9
https://doi.org/10.1093/jac/dkt368
https://doi.org/10.1093/jac/dkt368
Autor:
Simon, Dewar, Natasha, Sienkiewicz, Han B, Ong, Richard J, Wall, David, Horn, Alan H, Fairlamb
Publikováno v:
The Journal of Biological Chemistry
The aim of this study was to identify and characterize mechanisms of resistance to antifolate drugs in African trypanosomes. Genome-wide RNAi library screens were undertaken in bloodstream form Trypanosoma brucei exposed to the antifolates methotrexa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::69e4d33d3954b330a305e64bafb10831
https://pubmed.ncbi.nlm.nih.gov/27703008
https://pubmed.ncbi.nlm.nih.gov/27703008