Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Simon Devos"'
Autor:
Loes van Schie, Wander Van Breedam, Charlotte Roels, Bert Schepens, Martin Frank, Ahmad Reza Mehdipour, Bram Laukens, Wim Nerinckx, Francis Santens, Simon Devos, Iebe Rossey, Karel Thooft, Sandrine Vanmarcke, Annelies Van Hecke, Xavier Saelens, Nico Callewaert
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTAs small and stable high-affinity antigen binders, VHHs boast attractive characteristics both for therapeutic use in various disease indications, and as versatile reagents in research and diagnostics. To further increase the versatility of VH
Externí odkaz:
https://doaj.org/article/67952f97f7f1443594a2016e37e133b0
Publikováno v:
Frontiers in Microbiology, Vol 7 (2016)
Cystic fibrosis (CF) is the most common lethal inherited disorder in Caucasians. It is caused by mutation of the CF transmembrane conductance regulator (CFTR) gene. A defect in the CFTR ion channel causes a dramatic change in the composition of the a
Externí odkaz:
https://doaj.org/article/a4960557b05243e295afcf4fdbb582d5
Autor:
Karel Thooft, Wander Van Breedam, Francis Santens, Elise Wyseure, Sandrine Vanmarcke, Simon Devos, Nico Callewaert, Annemieke Madder
Publikováno v:
Organic & Biomolecular Chemistry. 20:464-471
Recently, the GlyConnect-oxime (GC) protein conjugation strategy was developed to provide a site-selective glycan-based conjugation strategy as an extension to the in-house developed GlycoDelete (GD) technology. GD gives access to glycoproteins with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f49dfffd44cbe1377091c5428e41a23
https://doi.org/10.1039/d1ob02299g
https://doi.org/10.1039/d1ob02299g
Autor:
Loes van Schie, Wander Van Breedam, Charlotte Roels, Bert Schepens, Martin Frank, Ahmad Reza Mehdipour, Bram Laukens, Wim Nerinckx, Francis Santens, Simon Devos, Iebe Rossey, Karel Thooft, Sandrine Vanmarcke, Annelies Van Hecke, Nico Callewaert
As small and stable high-affinity antigen binders, VHHs boast attractive characteristics both for therapeutic use in various disease indications, and as versatile reagents in research and diagnostics. To further increase the versatility of VHHs, we e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c486437c202134b05a583afd2cdee669
https://doi.org/10.1101/2022.04.25.489312
https://doi.org/10.1101/2022.04.25.489312
Autor:
Iebe Rossey, Sandrine Vanmarcke, Sieglinde De Cae, Joana Rocha-Pereira, Xavier Saelens, Martin Schwemmle, Wander Van Breedam, Andrew Popplewell, Nick Devoogdt, Laurens Liesenborghs, Dominique Tersago, Annette Ohnemus, Kenny Roose, Simon Devos, Julius Beer, Piet Maes, Frank Peelman, Daniel Schnepf, Peter Staeheli, Sofie Jacobs, Wim Nerinckx, Massimiliano Germani, Catelijne Stortelers, George D. Moschonas, Kevin Brady, Alison Turner, Rana Abdelnabi, Daria Fijalkowska, Wannes Weyts, Isabel Remory, Leen Delang, Lana Langendries, Laura Seldeslachts, João Paulo Portela Catani, Bruno Dombrecht, Dries Van Herpe, Dirk Jochmans, Loes van Schie, Koen Sedeyn, Greetje Vande Velde, Chiara Lonigro, Sarah Creytens, Xin Zhang, Bert Schepens, Sebastiaan ter Horst, Kai Dallmeier, Hannah Eeckhaut, Caroline Shi-Yan Foo, Jimmy Borloo, Robbert Boudewijns, Suzanne J.F. Kaptein, James Heads, Nico Callewaert, Birgit Weynand, Mark Ellis, Ana Filipa Oliveira, Annelies Van Hecke, Gitte Michielsen, Dorien De Vlieger, Jackeline Cecilia Zavala Marchan, Alistair Henry, Johan Neyts, Hendrik Jan Thibaut
Publikováno v:
SCIENCE TRANSLATIONAL MEDICINE
Broadly neutralizing antibodies are an important treatment for individuals with coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Antibody-based therapeutics are also essential for pandemic pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3830e9b60d433a409a79548892804d43
https://lirias.kuleuven.be/handle/123456789/682263
https://lirias.kuleuven.be/handle/123456789/682263
Autor:
Simon Devos, Wyseure E, Bram Laukens, Van Moer B, Wim Nerinckx, Nico Callewaert, Sandrine Vanmarcke, Thooft K, Van Breedam W, Francis Santens, Madder A
Recently, our lab developed GlycoDelete, a technology suite that allows a radical simplification of eukaryotic N-glycosylation. The technology allows to produce glycoproteins that carry single GlcNAc, LacNAc, or LacNAc-Sia type glycans on their N-lin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::273a28951088fabdacd522f49ce69471
https://doi.org/10.1101/2021.06.02.446789
https://doi.org/10.1101/2021.06.02.446789
Autor:
An-Katrien Minnaert, Loes van Schie, Hendrik Grootaert, Jonas Himpe, Simon Devos, Wannes Weyts, Herlinde De Keersmaecker, Kevin Braeckmans, Elisabeth Van Aken, Joris R Delanghe, Stefaan C. De Smedt, Nico Callewaert, Katrien Remaut
Publikováno v:
International Journal of Pharmaceutics. 621:121772
Globally, over 2 billion people suffer from vision impairment. Despite complex multifactorial etiology, advanced glycation end products are involved in the pathogenesis of many causative age- and diabetes-related eye diseases. Deglycating enzyme fruc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::624828fe6463da184a7aa7681de43290
https://doi.org/10.1016/j.ijpharm.2022.121772
https://doi.org/10.1016/j.ijpharm.2022.121772
Autor:
Piet Maes, Martin Schwemmle, Allison Turner, Annette Ohnemus, Wander Van Breedam, Greetje Vande Velde, Bert Schepens, Sieglinde De Cae, Suzanne J.F. Kaptein, Nick Devoogdt, James Heads, Mark Ellis, Peter Staeheli, Gitte Michielsen, Bruno Dombrecht, Julius Beer, Dominique Tersago, Robbert Boudewijns, Sofie Jacobs, Leen Delang, Dries Van Herpe, João Paulo Portela Catani, Dirk Jochmans, Alistair Henry, Rana Abdelnabi, Nico Callewaert, Birgit Weynand, Sandrine Vanmarcke, Sarah Creytens, Simon Devos, George D. Moschonas, Isabel Remory, Annelies Van Hecke, Lana Langendries, Daniel Schnepf, Catelijne Stortelers, Koen Sedeyn, Ana Filipa Oliveira, Laura Seldeslachts, Xin Zhang, Xavier Saelens, Loes van Schie, Laurens Liesenborghs, Dorien De Vlieger, Chiara Lonigro, Frank Peelman, Massimiliano Germano, Joana Rocha-Pereira, Kevin Brady, Wannes Weyts, Hendrik Jan Tibaut, Sebastiaan ter Horst, Kai Dallmeier, Hannah Eeckhaut, Jackeline Cecilia Zavala Marchan, Kenny Roose, Johan Neyts, Wim Nerinckx, Daria Fijalkowska, Andy Popplewell, Iebe Rossey, Caroline Shi-Yan Foo, Jimmy Borloo
We have identified camelid single-domain antibodies (VHHs) that cross-neutralize SARS-CoV-1 and −2, such as VHH72, which binds to a unique highly conserved epitope in the viral receptor-binding domain (RBD) that is difficult to access for human ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d213f47d21cc67cf73c8fd52a12112a4
https://doi.org/10.1101/2021.03.08.433449
https://doi.org/10.1101/2021.03.08.433449
Autor:
Charlot De Wachter, Katelijne Geysens, Paul Ameloot, Nico Callewaert, Bart Samyn, Roland Contreras, José Martins, Pieter P. Jacobs, Jurgen Haustraete, Jean-Christophe Renauld, Simon Devos, Bram Laukens, Willy Morelle
Publikováno v:
Biotechnology and bioengineering
Biotechnology and bioengineering, 2020, Biotechnology and bioengineering, 117 (8), pp.2479-2488. ⟨10.1002/bit.27375⟩
Biotechnology and bioengineering, 2020, Biotechnology and bioengineering, 117 (8), pp.2479-2488. ⟨10.1002/bit.27375⟩
BackgroundThe glycosylation pathways of several eukaryotic protein expression hosts are being engineered to enable the production of therapeutic glycoproteins with humanized application-customized glycan structures. In several expression hosts, this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b98af807cd471ca24cf4ebc4de82e33
https://doi.org/10.1101/2020.01.28.923631
https://doi.org/10.1101/2020.01.28.923631
Autor:
Kevin Braeckmans, Gonzalez Van Driessche, Wouter Van Putte, Simon Devos, Wim Van Den Broek, Stephan Stremersch, Savvas N. Savvides, Koen Raemdonck, Henning Stahlberg, Bart Devreese, Jolien Vitse, Misha Kudryashev
Publikováno v:
Environmental Microbiology. 19:3930-3937
Several bacterial species produce membrane vesicles (MVs) in response to antibiotic stress. However, the biogenesis and role of MVs in bacterial antibiotic resistance mechanisms have remained unclear. Here, we studied the effect of the fluoroquinolon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96b737c12d5165b44d1e13c2f140685d
https://doi.org/10.1111/1462-2920.13793
https://doi.org/10.1111/1462-2920.13793