Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Simon D Message"'
Autor:
Vasile Laza-Stanca, Simon D Message, Michael R Edwards, Hayley L Parker, Mihnea T Zdrenghea, Tatiana Kebadze, Onn M Kon, Patrick Mallia, Luminita A Stanciu, Sebastian L Johnston
Publikováno v:
PLoS Pathogens, Vol 7, Iss 7, p e1002114 (2011)
Rhinovirus infections are the major cause of asthma exacerbations. We hypothesised that IL-15, a cytokine implicated in innate and acquired antiviral immunity, may be deficient in asthma and important in the pathogenesis of asthma exacerbations. We i
Externí odkaz:
https://doaj.org/article/e9e8861e165547c4b6caaaf773a7fc0f
Autor:
Louise Slater, Nathan W Bartlett, Jennifer J Haas, Jie Zhu, Simon D Message, Ross P Walton, Annemarie Sykes, Samer Dahdaleh, Deborah L Clarke, Maria G Belvisi, Onn M Kon, Takashi Fujita, Peter K Jeffery, Sebastian L Johnston, Michael R Edwards
Publikováno v:
PLoS Pathogens, Vol 6, Iss 11, p e1001178 (2010)
The relative roles of the endosomal TLR3/7/8 versus the intracellular RNA helicases RIG-I and MDA5 in viral infection is much debated. We investigated the roles of each pattern recognition receptor in rhinovirus infection using primary bronchial epit
Externí odkaz:
https://doaj.org/article/7aaa3892a9194b66b016b415e301e757
Autor:
Kirstin Jansen, Tatiana Kebadze, Oliver F. Wirz, David Mirer, Kari C. Nadeau, Willem van de Veen, James E. Gern, Pattraporn Satitsuksanoa, Patrick Mallia, Nikolaos G. Papadopoulos, Cezmi A. Akdis, M. Akdis, Simon D. Message, Ge Tan, Nicholas Glanville, Sebastian L. Johnston, Barbara Stanic, Milena Sokolowska
Publikováno v:
Allergy. 77:130-142
Background Rhinoviruses are the predominant cause of respiratory viral infections and are strongly associated with asthma exacerbations. While humoral immunity plays an important role during virus infections, cellular aspects of this response are les
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cee237c877575f75a2f49a8736825b6
https://doi.org/10.1111/all.14985
https://doi.org/10.1111/all.14985
Characterisation of patients with severe asthma in the UK Severe Asthma Registry in the biologic era
Autor:
Simon D. Message, John Busby, Tom Brown, Adel H. Mansur, Paul E Pfeffer, Martin Doherty, Andrew Menzies-Gow, Liam G Heaney, Robert Niven, Robin Gore, Mitesh Patel, David A. Jackson
Publikováno v:
Thorax
Jackson, D J, Busby, J, Pfeffer, P E, Menzies-Gow, A, Brown, T, Gore, R, Doherty, M, Mansur, A, Message, S, Niven, R, Patel, M & Heaney, L 2020, ' Characterisation of patients with severe asthma in the UK Severe Asthma Registry in the biologic era ', Thorax . https://doi.org/10.1136/thoraxjnl-2020-215168
Jackson, D J, Busby, J, Pfeffer, P E, Menzies-Gow, A, Brown, T, Gore, R, Doherty, M, Mansur, A, Message, S, Niven, R, Patel, M & Heaney, L 2020, ' Characterisation of patients with severe asthma in the UK Severe Asthma Registry in the biologic era ', Thorax . https://doi.org/10.1136/thoraxjnl-2020-215168
BackgroundThe UK Severe Asthma Registry (UKSAR) is the world’s largest national severe asthma registry collecting standardised data on referrals to UK specialist services. Novel biologic therapies have transformed the management of type 2(T2)-high
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc735c28b969a45e0dc8db1f57bca099
https://doi.org/10.1136/thoraxjnl-2020-215168
https://doi.org/10.1136/thoraxjnl-2020-215168
Autor:
Nathan W. Bartlett, Louise Slater, Nicholas Glanville, Jennifer J. Haas, Gaetano Caramori, Paolo Casolari, Deborah L. Clarke, Simon D. Message, Julia Aniscenko, Tatiana Kebadze, Jie Zhu, Patrick Mallia, Joseph P. Mizgerd, Maria Belvisi, Alberto Papi, Sergei V. Kotenko, Sebastian L. Johnston, Michael R. Edwards
Publikováno v:
EMBO Molecular Medicine, Vol 4, Iss 12, Pp 1244-1260 (2012)
Abstract The importance of NF‐κB activation and deficient anti‐viral interferon induction in the pathogenesis of rhinovirus‐induced asthma exacerbations is poorly understood. We provide the first in vivo evidence in man and mouse that rhinovir
Externí odkaz:
https://doaj.org/article/0ec2c26245a34afd8764bd89457e54ee
Autor:
Robin Gore, David Price, John Busby, Robert Stone, David A. Jackson, Mitesh Patel, Liam G Heaney, Paddy Dennison, Salman Siddiqui, Tom Brown, Paul E Pfeffer, Robert Niven, Adel H. Mansur, Simon D. Message, Andrew Menzies-Gow, Rekha Chaudhuri
Publikováno v:
Epidemiology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::149ff82422844da17f91cc0b5f3e54d5
https://doi.org/10.1183/13993003.congress-2021.oa1325
https://doi.org/10.1183/13993003.congress-2021.oa1325
Autor:
Kari C. Nadeau, Nicholas Glanville, Pattraporn Satitsuksanoa, Kirstin Jansen, Sebastian L. Johnston, Milena Sokolowska, Mübeccel Akdis, David Mirer, Tatiana Kebadze, Andrzej Eljaszewicz, Simon D. Message, James E. Gern, Willem van de Veen, Roman Skiepko, Nikolaos G. Papadopoulos, Cezmi A. Akdis, Carlos Cardoso, Ge Tan, Marcin Moniuszko, Oliver F. Wirz, Patrick Mallia
Publikováno v:
The Journal of allergy and clinical immunology. 148(4)
Background Respiratory infections with rhinoviruses (RV) are strongly associated with development and exacerbations of asthma, and they pose an additional health risk for subjects with allergy. Objective How RV infections and chronic allergic disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d63025761704a79cb2bc127c809c16f
https://pubmed.ncbi.nlm.nih.gov/34153372
https://pubmed.ncbi.nlm.nih.gov/34153372
Autor:
Liam G Heaney, David Price, Tom Brown, Paddy Dennison, Robin Gore, Andrew Menzies-Gow, Mitesh Patel, Robert A. Stone, Simon D. Message, John Busby, Adel H. Mansur, Paul E Pfeffer, Robert Niven, Salman Siddiqui, Rekha Chaudhuri, David A. Jackson, UK Severe Asthma Registry
Publikováno v:
Busby, J, Heaney, L, Brown, T, Chaudhuri, R, Dennison, P, Gore, R, Jackson, D J, Mansur, A H, Menzies-Gow, A N, Message, S, Niven, R, Patel, M, Price, D, Siddiqui, S, Stone, R & Pfeffer, P 2022, ' Ethnic Differences in Severe Asthma Clinical Care and Outcomes: An Analysis of United Kingdom Primary and Specialist Care ', The journal of allergy and clinical immunology. In practice, vol. 10, no. 2, pp. 495-505 . https://doi.org/10.1016/j.jaip.2021.09.034
Background Understanding the effects of ethnicity in severe asthma is important for optimal personalized patient care. Objective To assess ethnic differences in disease control, exacerbations, biological phenotype, and treatment in severe asthma in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c8c038b562b55a9ff085e99c279aa64
https://doi.org/10.1016/j.jaip.2021.09.034
https://doi.org/10.1016/j.jaip.2021.09.034
Autor:
Onn Min Kon, Alberto Papi, Luminita A. Stanciu, Jie Zhu, Christine K. Ward, Marco Contoli, Simon D. Message, Mary Ann Mascelli, Michael R. Edwards, Peter K. Jeffery, Elliot S. Barnathan, Tatiana Kebadze, Sebastian L. Johnston, Patrick Mallia
Publikováno v:
The Journal of Allergy and Clinical Immunology
Background The innate immune system senses viral infection through pattern recognition receptors (PRRs), leading to type I interferon production. The role of type I interferon and PPRs in rhinovirus-induced asthma exacerbations in vivo are uncertain.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b155e0565de09a673f8091ddc072c443
http://hdl.handle.net/11392/2397435
http://hdl.handle.net/11392/2397435
Autor:
A Sahal, P Nagakumar, AH Mansur, J Marsh, S O’Hickey, D Wilson, Martin Doherty, Simon D. Message, Devika Subramanian, C Taylor, A Szuszmann, A Pillai
Publikováno v:
Asthma: from diagnosis to treatment.
Background Severe asthma service specification (NHS England Service Specification No. 170002/S) advocates the development of regional severe asthma networks to improve patient outcomes and manage delivery of expensive treatments. The Birmingham Regio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a949008586fc7a6a175f932b0055ae30
https://doi.org/10.1136/thorax-2018-212555.290
https://doi.org/10.1136/thorax-2018-212555.290