Morphological, electrophysiological, and molecular alterations in foetal noncompacted cardiomyopathy induced by disruption of ROCK signalling

Autor: David Sedmera, Veronika Olejnickova, Barbora Sankova, Hana Kolesova, Martin Bartos, Alena Kvasilova, Lauren C. Phillips, Simon D. Bamforth, Helen M. Phillips

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 12 (2024)

Left ventricular noncompaction cardiomyopathy is associated with heart failure, arrhythmia, and sudden cardiac death. The developmental mechanism underpinning noncompaction in the adult heart is still not fully understood, with lack of trabeculae com

Externí odkaz: https://doaj.org/article/6984b175bd1246a19b4ac401b0dcb189

Morphogenetic processes in the development and evolution of the arteries of the pharyngeal arches: their relations to congenital cardiovascular malformations

Autor: Anthony Graham, Jill P. J. M. Hikspoors, Wouter H. Lamers, Robert H. Anderson, Simon D. Bamforth

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 11 (2023)

The heart and aortic arch arteries in amniotes form a double circulation, taking oxygenated blood from the heart to the body and deoxygenated blood to the lungs. These major vessels are formed in embryonic development from a series of paired and symm

Externí odkaz: https://doaj.org/article/3e1123e0f96d4112a0030df6476909f6

ETS1 loss in mice impairs cardiac outflow tract septation via a cell migration defect autonomous to the neural crest

Autor: Lizhu Lin, Antonella Pinto, Lu Wang, Kazumi Fukatsu, Yan Yin, Simon D Bamforth, Marianne E Bronner, Sylvia M Evans, Shuyi Nie, Robert H Anderson, Alexey V Terskikh, Paul D Grossfeld

Publikováno v: Hum Mol Genet

Ets1 deletion in some mouse strains causes septal defects and has been implicated in human congenital heart defects in Jacobsen syndrome, in which one copy of the Ets1 gene is missing. Here, we demonstrate that loss of Ets1 in mice results in a decre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::530fac0d4e1c244c0f83930bff3b4991
https://doi.org/10.1093/hmg/ddac174

Early Embryonic Expression of AP-2α Is Critical for Cardiovascular Development

Autor: Amy-Leigh Johnson, Jürgen E. Schneider, Timothy J. Mohun, Trevor Williams, Shoumo Bhattacharya, Deborah J. Henderson, Helen M. Phillips, Simon D. Bamforth

Publikováno v: Journal of Cardiovascular Development and Disease, Vol 7, Iss 3, p 27 (2020)

Congenital cardiovascular malformation is a common birth defect incorporating abnormalities of the outflow tract and aortic arch arteries, and mice deficient in the transcription factor AP-2α (Tcfap2a) present with complex defects affecting these st

Externí odkaz: https://doaj.org/article/350e5470eb3f4e3491b1366b073b678a

Msx1 haploinsufficiency modifies the Pax9-deficient cardiovascular phenotype

Autor: Ramada R. Khasawneh, Simon D. Bamforth, Helen M. Phillips, Timothy J. Mohun, Jürgen E. Schneider, Stéphane Zaffran, Heiko Peters, Ralf Kist, Rachel Queen, Rafiqul Hussain, Jonathan Coxhead

Publikováno v: BMC Developmental Biology, Vol 21, Iss 1, Pp 1-20 (2021)
BMC Developmental Biology
BMC Developmental Biology, BioMed Central, 2021, 21 (1), pp.14. ⟨10.1186/s12861-021-00245-5⟩
BMC Developmental Biology, 2021, 21 (1), pp.14. ⟨10.1186/s12861-021-00245-5⟩

Background Successful embryogenesis relies on the coordinated interaction between genes and tissues. The transcription factors Pax9 and Msx1 genetically interact during mouse craniofacial morphogenesis, and mice deficient for either gene display abno

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c03a87f7d831ce7e331600e5caebbee
https://doaj.org/article/b7355328ecb548c9b658f6fd48c10d6d