Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Simon D, Van Haren"'
Autor:
David Martino, Nikki Schultz, Ravinder Kaur, Simon D. van Haren, Nina Kresoje, Annmarie Hoch, Joann Diray-Arce, Jessica Lasky Su, Ofer Levy, Michael Pichichero, in association with the IDEAL Consortium
Publikováno v:
Clinical Epigenetics, Vol 16, Iss 1, Pp 1-10 (2024)
Abstract Background Infants with frequent viral and bacterial respiratory infections exhibit compromised immunity to routine immunizations. They are also more likely to develop chronic respiratory diseases in later childhood. This study investigated
Externí odkaz:
https://doaj.org/article/1df925cfe6e94a84994fa8b2020d83e2
Autor:
Julie Zimmermann, Simon D. van Haren, Joann Diray-Arce, Ignatius Ryan Adriawan, Katharina Wørzner, Ricki T. Krog, Safia Guleed, Tu Hu, Rasmus Mortensen, Jes Dietrich, Sara M. Ø. Solbak, Ofer Levy, Dennis Christensen, Gabriel K. Pedersen
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-12 (2023)
Abstract Class-switching to IgG2a/c in mice is a hallmark response to intracellular pathogens. T cells can promote class-switching and the predominant pathway for induction of IgG2a/c antibody responses has been suggested to be via stimulation from T
Externí odkaz:
https://doaj.org/article/b2a5b6ac83564fccb7d1fc8c4727c789
Autor:
Simon Doss-Gollin, Sanya Thomas, Byron Brook, Kimia Abedi, Célia Lebas, Floriane Auderset, Yamile Lugo-Rodriguez, Guzman Sanchez-Schmitz, David J. Dowling, Ofer Levy, Simon D. van Haren
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-11 (2023)
Abstract Adjuvants can enhance vaccine immunogenicity, but their mechanism of action is often incompletely understood, hampering rapid applicability for pandemic vaccines. Herein, we characterized the cellular and molecular activity of adjuvant formu
Externí odkaz:
https://doaj.org/article/2f2d3c26cb064f4eb1447fb952873fcf
Autor:
Julie Zimmermann, Simon D. van Haren, Joann Diray-Arce, Ignatius Ryan Adriawan, Katharina Wørzner, Ricki T. Krog, Safia Guleed, Tu Hu, Rasmus Mortensen, Jes Dietrich, Sara M. Ø. Solbak, Ofer Levy, Dennis Christensen, Gabriel K. Pedersen
Publikováno v:
npj Vaccines, Vol 9, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/63c1f7f21415417bb945389bc0db3129
Autor:
Simon D. van Haren, Gabriel K. Pedersen, Azad Kumar, Tracy J. Ruckwardt, Syed Moin, Ian N. Moore, Mahnaz Minai, Mark Liu, Jensen Pak, Francesco Borriello, Simon Doss-Gollin, Elisabeth M. S. Beijnen, Saima Ahmed, Michaela Helmel, Peter Andersen, Barney S. Graham, Hanno Steen, Dennis Christensen, Ofer Levy
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Respiratory syncytial virus is a major pathogen with burden observed and associated with childhood infection. Here the authors characterise a cationic adjuvant formulation and show single immunisation results in protection in a murine neonate model o
Externí odkaz:
https://doaj.org/article/928f6a30307d40df8ee70a438b361824
Autor:
Joann Diray-Arce, Asimenia Angelidou, Kristoffer Jarlov Jensen, Maria Giulia Conti, Rachel S. Kelly, Matthew A. Pettengill, Mark Liu, Simon D. van Haren, Scott D. McCulloch, Greg Michelloti, Olubukola Idoko, Tobias R. Kollmann, Beate Kampmann, Hanno Steen, Al Ozonoff, Jessica Lasky-Su, Christine S. Benn, Ofer Levy
Publikováno v:
Cell Reports, Vol 39, Iss 5, Pp 110772- (2022)
Summary: Vaccines have generally been developed with limited insight into their molecular impact. While systems vaccinology enables characterization of mechanisms of action, these tools have yet to be applied to infants, who are at high risk of infec
Externí odkaz:
https://doaj.org/article/d0c46f541a054652876a5e94cbd057cb
Publikováno v:
Vaccines, Vol 11, Iss 3, p 509 (2023)
Clinical manifestations from primary COVID infection in children are generally less severe as compared to adults, and severe pediatric cases occur predominantly in children with underlying medical conditions. However, despite the lower incidence of d
Externí odkaz:
https://doaj.org/article/841669f7bb2449ffaeb966d3610c66da
Autor:
Asimenia Angelidou, Joann Diray-Arce, Maria-Giulia Conti, Mihai G. Netea, Bastiaan A. Blok, Mark Liu, Guzman Sanchez-Schmitz, Al Ozonoff, Simon D. van Haren, Ofer Levy
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
BackgroundNewborns exhibit distinct immune responses and are at high risk of infection. Neonatal immunization with BCG, the live attenuated vaccine against tuberculosis (TB), is associated with broad protection against a range of unrelated pathogens,
Externí odkaz:
https://doaj.org/article/0a3acecd6b914e248ee7963c45a6dd06
Autor:
Amy H. Lee, Casey P. Shannon, Nelly Amenyogbe, Tue B. Bennike, Joann Diray-Arce, Olubukola T. Idoko, Erin E. Gill, Rym Ben-Othman, William S. Pomat, Simon D. van Haren, Kim-Anh Lê Cao, Momoudou Cox, Alansana Darboe, Reza Falsafi, Davide Ferrari, Daniel J. Harbeson, Daniel He, Cai Bing, Samuel J. Hinshaw, Jorjoh Ndure, Jainaba Njie-Jobe, Matthew A. Pettengill, Peter C. Richmond, Rebecca Ford, Gerard Saleu, Geraldine Masiria, John Paul Matlam, Wendy Kirarock, Elishia Roberts, Mehrnoush Malek, Guzmán Sanchez-Schmitz, Amrit Singh, Asimenia Angelidou, Kinga K. Smolen, The EPIC Consortium, Ryan R. Brinkman, Al Ozonoff, Robert E. W. Hancock, Anita H. J. van den Biggelaar, Hanno Steen, Scott J. Tebbutt, Beate Kampmann, Ofer Levy, Tobias R. Kollmann
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
The first week of life impacts health for all of life, but the mechanisms are little-understood. Here the authors extract multi-omic data from small volumes of blood to study the dynamic molecular changes during the first week of life, revealing a ro
Externí odkaz:
https://doaj.org/article/e7ef77b9e7334ea3b111c65372e1f94f
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Infections are most common and most severe at the extremes of age, the young and the elderly. Vaccination can be a key approach to enhance immunogenicity and protection against pathogens in these vulnerable populations, who have a functionally distin
Externí odkaz:
https://doaj.org/article/0c4de1e067f24754b52164401ce1f3df