Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Simon C. Mendelsohn"'
Publikováno v:
Vaccine: X, Vol 13, Iss , Pp 100267- (2023)
Safe, effective, and accessible vaccines are urgently needed to end tuberculosis (TB) by 2030. The 6th Global Forum on TB Vaccines, convened virtually 22–25 February 2022, was hosted by Toulouse, France, under the high patronage of President Emmanu
Externí odkaz:
https://doaj.org/article/8af1842896184c39b497e95d1022b6d0
Autor:
Simon C. Mendelsohn, Stanley Kimbung Mbandi, Andrew Fiore-Gartland, Adam Penn-Nicholson, Munyaradzi Musvosvi, Humphrey Mulenga, Michelle Fisher, Katie Hadley, Mzwandile Erasmus, Onke Nombida, Michèle Tameris, Gerhard Walzl, Kogieleum Naidoo, Gavin Churchyard, Mark Hatherill, Thomas J. Scriba
Publikováno v:
Communications Medicine, Vol 2, Iss 1, Pp 1-13 (2022)
Plain Language Summary Delays in tuberculosis (TB) diagnosis result in increased disease severity, risk of death, and infection of further individuals. The presence of symptoms is typically used to find people with TB. However, about half of individu
Externí odkaz:
https://doaj.org/article/f90b0c58dc174fb6836e87d990937f91
Publikováno v:
BMC Medicine, Vol 19, Iss 1, Pp 1-11 (2021)
Abstract Background Tuberculosis (TB) preventive therapy is recommended for all people living with HIV (PLHIV). Despite the elevated risk of TB amongst PLHIV, most of those eligible for preventive therapy would never develop TB. Tests which can ident
Externí odkaz:
https://doaj.org/article/4b751cf0231a43558b1c9e5a31b5cd8f
Autor:
Timothy F. Spracklen, Simon C. Mendelsohn, Claire Butters, Heidi Facey-Thomas, Raphaella Stander, Debbie Abrahams, Mzwandile Erasmus, Richard Baguma, Jonathan Day, Christiaan Scott, Liesl J. Zühlke, George Kassiotis, Thomas J. Scriba, Kate Webb
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
IntroductionMultisystem inflammatory syndrome in children (MIS-C) is a severe acute inflammatory reaction to SARS-CoV-2 infection in children. There is a lack of data describing differential expression of immune genes in MIS-C compared to healthy chi
Externí odkaz:
https://doaj.org/article/d7ac4d8646a54854b4af3a86f551f2e7
Autor:
Humphrey Mulenga, Andrew Fiore-Gartland, Simon C. Mendelsohn, Adam Penn-Nicholson, Stanley Kimbung Mbandi, Elisa Nemes, Bhavesh Borate, Munyaradzi Musvosvi, Michèle Tameris, Gerhard Walzl, Kogieleum Naidoo, Gavin Churchyard, Thomas J. Scriba, Mark Hatherill
Publikováno v:
EClinicalMedicine, Vol 47, Iss , Pp 101396- (2022)
Summary: Background: We evaluated the diagnostic and prognostic performance of a transcriptomic signature of tuberculosis (TB) risk (RISK11) and QuantiFERON-TB Gold-plus (QFTPlus) as combination biomarkers of TB risk. Methods: Healthy South Africans
Externí odkaz:
https://doaj.org/article/9b2aaeb1baa7408eaa1e56d396640806
Autor:
Humphrey Mulenga, Andrew Fiore-Gartland, Simon C. Mendelsohn, Adam Penn-Nicholson, Stanley Kimbung Mbandi, Bhavesh Borate, Munyaradzi Musvosvi, Michèle Tameris, Gerhard Walzl, Kogieleum Naidoo, Gavin Churchyard, Thomas J. Scriba, Mark Hatherill
Publikováno v:
EBioMedicine, Vol 77, Iss , Pp 103886- (2022)
Summary: Background: We aimed to understand host factors that affect discriminatory performance of a transcriptomic signature of tuberculosis risk (RISK11). Methods: HIV-negative adults aged 18–60 years were evaluated in a prospective study of RISK
Externí odkaz:
https://doaj.org/article/1a05f45fbb97478f8d9a44256aabf744
Autor:
Simon C. Mendelsohn, Andrew Fiore-Gartland, Denis Awany, Humphrey Mulenga, Stanley Kimbung Mbandi, Michèle Tameris, Gerhard Walzl, Kogieleum Naidoo, Gavin Churchyard, Thomas J. Scriba, Mark Hatherill
Publikováno v:
EClinicalMedicine, Vol 45, Iss , Pp 101328- (2022)
Summary: Background: Tuberculosis (TB) clinical prediction rules rely on presence of symptoms, however many undiagnosed cases in the community are asymptomatic. This study aimed to explore the utility of clinical factors in predicting TB among people
Externí odkaz:
https://doaj.org/article/f7f9a32f94cd4a46873cc5dd3ec62d66
Autor:
Rachel A. Bender Ignacio, Jessica Long, Aparajita Saha, Felicia K. Nguyen, Lara Joudeh, Ethan Valinetz, Simon C. Mendelsohn, Thomas J. Scriba, Mark Hatherill, Holly Janes, Gavin Churchyard, Susan Buchbinder, Ann Duerr, Javeed A. Shah, Thomas R. Hawn
Publikováno v:
PLoS ONE, Vol 17, Iss 5 (2022)
Background Although immune activation is associated with HIV acquisition, the nature of inflammatory profiles that increase HIV risk, which may include responses to M. tuberculosis (Mtb) infection, are not well characterized. Methods We conducted a n
Externí odkaz:
https://doaj.org/article/40d7746c9eda499fb12fa9fe7b27ab32
Autor:
Pramila Rijal, Sean C. Elias, Samara Rosendo Machado, Julie Xiao, Lisa Schimanski, Victoria O’Dowd, Terry Baker, Emily Barry, Simon C. Mendelsohn, Catherine J. Cherry, Jing Jin, Geneviève M. Labbé, Francesca R. Donnellan, Tommy Rampling, Stuart Dowall, Emma Rayner, Stephen Findlay-Wilson, Miles Carroll, Jia Guo, Xiao-Ning Xu, Kuan-Ying A. Huang, Ayato Takada, Gillian Burgess, David McMillan, Andy Popplewell, Daniel J. Lightwood, Simon J. Draper, Alain R. Townsend
Publikováno v:
Cell Reports, Vol 27, Iss 1, Pp 172-186.e7 (2019)
Summary: We describe therapeutic monoclonal antibodies isolated from human volunteers vaccinated with recombinant adenovirus expressing Ebola virus glycoprotein (EBOV GP) and boosted with modified vaccinia virus Ankara. Among 82 antibodies isolated f
Externí odkaz:
https://doaj.org/article/05ec511fa1b1484ababd7c9c79a01ba1
Autor:
Ethan D. Valinetz, Daniel Matemo, Jill K. Gersh, Lara L. Joudeh, Simon C. Mendelsohn, Thomas J. Scriba, Mark Hatherill, John Kinuthia, Anna Wald, Gerard A. Cangelosi, Ruanne V. Barnabas, Thomas R. Hawn, David J. Horne
Publikováno v:
AIDS (London, England). 36(10)
To examine the association between isoniazid preventive therapy (IPT) or nontuberculous mycobacteria (NTM) sputum culture positivity and tuberculosis (TB) transcriptional signatures in people with HIV.Cross-sectional study.We enrolled adults living w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::573ee240d6f076ef5a2ce28c66547f76
https://pubmed.ncbi.nlm.nih.gov/35608118
https://pubmed.ncbi.nlm.nih.gov/35608118