Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Simon C. Burton"'
Autor:
Simon C. Burton, Bruce R. Lawford, Mark Barnes, Karrin Hausdorf, Karen Heslop, Ross McD. Young, Ernest P. Noble
Publikováno v:
Australian & New Zealand Journal of Psychiatry. 40:575-580
Objective: Smoking rate is disproportionately high among patients with schizophrenia, resulting in significant morbidity and mortality. However, cigarette smoking has been reported to have beneficial effects on negative symptoms, extrapyramidal sympt
Autor:
C. Phillip Morris, Mark Barnes, Bruce R. Lawford, Angela van Daal, Ross McD. Young, Christopher D. Swagell, Simon C. Burton, Susan Shadforth, Warren Ward, Karen Heslop
Publikováno v:
Schizophrenia Research. 73:31-37
The T allele of the human dopamine D2 receptor (DRD2) gene C957T polymorphism is associated with reduced mRNA translation and stability. This results in decreased dopamine induced DRD2 upregulation and decreased in vivo D2 dopamine binding. Conversel
Autor:
Ernest P. Noble, Simon C. Burton, Warren Ward, Mark Barnes, Ross McD. Young, Terry Ritchie, Bruce R. Lawford
Publikováno v:
British Journal of Psychiatry. 185:147-151
BackgroundHyperprolactinaemia induced by D2 dopamine receptor antagonist antipsychotic medication can result in significant health problems.AimsTo examine the role of DRD2 polymorphism on prolactin levels in patients treated with antipsychotic medica
Publikováno v:
Journal of Chromatography A. 943:77-90
A comparison is made of the performance of two types of adsorbent solid phases (commercially sourced Streamline composites and custom-assembled Zirblast pelliculates), derivatised with similar anion exchange chemistries and applied to the recovery of
Autor:
Simon C. Burton, David R. K. Harding
Publikováno v:
Journal of Biochemical and Biophysical Methods. 49:275-287
The role of chromatography in capture is reviewed in terms of the special requirements imposed by the processing of very crude feedstocks. Adsorption methods which are not significantly affected by variations of feedstock ionic strength are highlight
Autor:
David R. K. Harding, Simon C. Burton
Publikováno v:
Journal of Chromatography A. 796:273-282
Chromatographic matrices were produced by free radical addition reactions between immobilised allyl groups and suitable ligands. Efficient addition and high ligand densities were readily obtained with mercaptoacids, glutathione, mercaptoethanol and s
Publikováno v:
Biotechnology and Bioengineering. 56:45-55
Mixed mode Sepharose and Perloza bead cellulose matrices were prepared using various chemistries. These matrices contained hydrophobic (aliphatic and/or aromatic) and ionic (carboxylate or alkylamine) groups. Hydrophobic amine ligands were attached t
Autor:
Simon C. Burton, David R. K. Harding
Publikováno v:
Journal of Chromatography A. 775:39-50
Allylated cellulose, agarose and methacrylate matrices, activated with allyl bromide or allyl glycidyl ether, were modified by aqueous bromination, preferably with N-bromosuccinimide. Amine, thiol and sulphite ligands were attached efficiently and in
Autor:
Simon C. Burton, David R. K. Harding
Publikováno v:
Journal of Chromatography A. 775:29-38
Efficient carboxymethylation of a bead cellulose was achieved with dimethyl sulphoxide–water mixtures but low activation levels were found with epoxidation reagents. The highest activation levels were obtained with allyl bromide and allyl glycidyl
Publikováno v:
Journal of Chromatography A. 587:271-275
Previous procedures for addition of the spacer arm, 6-aminocaproic acid, to 1,1′-carbonyldiimidazole (CDI) activated matrices used dilute, largely aqueous reaction conditions. Only 20–50% of the activated groups were substituted. Treatment of CDI