Zobrazeno 1 - 10
of 240
pro vyhledávání: '"Simon C Body"'
Autor:
Steven G Carlisle, Hasan Albasha, Hector I Michelena, Anna Sabate-Rotes, Lisa Bianco, Julie De Backer, Laura Muiño Mosquera, Anji T Yetman, Malenka M Bissell, Maria Grazia Andreassi, Ilenia Foffa, Dawn S Hui, Anthony Caffarelli, Yuli Y Kim, Dongchuan Guo, Rodolfo Citro, Margot De Marco, Justin T Tretter, Kim L McBride, Dianna M Milewicz, Simon C Body, Siddharth K Prakash, EBAV Investigators, BAVCon Investigators
Publikováno v:
PLoS ONE, Vol 19, Iss 9, p e0304514 (2024)
Bicuspid aortic valve (BAV), the most common congenital heart defect, is a major cause of aortic valve disease requiring valve interventions and thoracic aortic aneurysms predisposing to acute aortic dissections. The spectrum of BAV ranges from early
Externí odkaz:
https://doaj.org/article/242c32ad450e4d989ceb2ddbfe7c7ae9
Autor:
Amanda A Fox, Mias Pretorius, Kuang-Yu Liu, Charles D Collard, Tjorvi E Perry, Stanton K Shernan, Philip L De Jager, David A Hafler, Daniel S Herman, Steven R DePalma, Dan M Roden, Jochen D Muehlschlegel, Brian S Donahue, Dawood Darbar, J G Seidman, Simon C Body, Christine E Seidman
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e24593 (2011)
Postoperative ventricular dysfunction (VnD) occurs in 9-20% of coronary artery bypass graft (CABG) surgical patients and is associated with increased postoperative morbidity and mortality. Understanding genetic causes of postoperative VnD should enha
Externí odkaz:
https://doaj.org/article/05775496b53341d6a3365358b16d9df5
Autor:
Evren Caglayan, Giulio R Romeo, Kai Kappert, Margarete Odenthal, Michael Südkamp, Simon C Body, Stanton K Shernan, Daniel Hackbusch, Marius Vantler, Andrius Kazlauskas, Stephan Rosenkranz
Publikováno v:
PLoS ONE, Vol 5, Iss 10, p e13608 (2010)
Profilin-1 is an ubiquitous actin binding protein. Under pathological conditions such as diabetes, profilin-1 levels are increased in the vascular endothelium. We recently demonstrated that profilin-1 overexpression triggers indicators of endothelial
Externí odkaz:
https://doaj.org/article/7779c1c25f124588b8a046ac99db84bd
Autor:
Shyamal R. Asher, Chin Siang Ong, Raymond J. Malapero, Mahyar Heydarpour, Gregory W. Malzberg, Jasmine T. Shahram, Thy B. Nguyen, Douglas C. Shook, Stanton K. Shernan, Prem Shekar, Tsuyoshi Kaneko, Rodolfo Citro, Jochen D. Muehlschlegel, Simon C. Body
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
ObjectivesIt is uncertain whether concurrent mitral valve repair or replacement for moderate or greater secondary mitral regurgitation at the time of coronary artery bypass graft or aortic valve replacement surgery improves long-term survival.Methods
Externí odkaz:
https://doaj.org/article/0b1e69727ce443caba0a7c25f688c2de
Autor:
Joshua D. Hutcheson, Florian Schlotter, Michael D. Creager, Xiaoshuang Li, Tan Pham, Payal Vyas, Hideyuki Higashi, Simon C. Body, Masanori Aikawa, Sasha A. Singh, Lidia Kos, Elena Aikawa
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 8 (2021)
Objective: Aortic valve (AV) leaflets rely on a precise extracellular matrix (ECM) microarchitecture for appropriate biomechanical performance. The ECM structure is maintained by valvular interstitial cells (VICs), which reside within the leaflets. T
Externí odkaz:
https://doaj.org/article/47338c0facdd40a98b9b1fd2834b708f
Autor:
Farwah Iqbal, Florian Schlotter, Dakota Becker-Greene, Adrien Lupieri, Claudia Goettsch, Joshua D Hutcheson, Maximillian A Rogers, Shinsuke Itoh, Arda Halu, Lang Ho Lee, Mark C Blaser, Andrew K Mlynarchik, Sumihiko Hagita, Shiori Kuraoka, Hao Yu Chen, James C Engert, Livia S A Passos, Prabhash K Jha, Eric A Osborn, Farouc A Jaffer, Simon C Body, Simon C Robson, George Thanassoulis, Masanori Aikawa, Sasha A Singh, Abhijeet R Sonawane, Elena Aikawa
Publikováno v:
European Heart Journal. 44:885-898
AimsCalcific aortic valve disease (CAVD) is the most common valve disease, which consists of a chronic interplay of inflammation, fibrosis, and calcification. In this study, sortilin (SORT1) was identified as a novel key player in the pathophysiology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17619affe70613293bf816312001402b
https://doi.org/10.1093/eurheartj/ehac818
https://doi.org/10.1093/eurheartj/ehac818
Autor:
Shohreh Maleki, Flore-Anne Poujade, Otto Bergman, Jesper R. Gådin, Nancy Simon, Karin Lång, Anders Franco-Cereceda, Simon C. Body, Hanna M. Björck, Per Eriksson
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 6 (2019)
Thoracic aortic aneurysm (TAA) is the progressive enlargement of the aorta due to destructive changes in the connective tissue of the aortic wall. Aneurysm development is silent and often first manifested by the drastic events of aortic dissection or
Externí odkaz:
https://doaj.org/article/2bdbaed0bf68414e95a4d6eae9fc4627
Autor:
Martin I Sigurdsson, Louis Saddic, Mahyar Heydarpour, Tzuu-Wang Chang, Prem Shekar, Sary Aranki, Gregory S Couper, Stanton K. Shernan, Jochen D. Muehlschlegel, Simon C. Body
Publikováno v:
BMC Medical Genomics, Vol 10, Iss 1, Pp 1-11 (2017)
Abstract Background Both ambulatory atrial fibrillation (AF) and post-operative AF (poAF) are associated with substantial morbidity and mortality. Analyzing the tissue-specific gene expression in the left atrium (LA) can identify novel genes associat
Externí odkaz:
https://doaj.org/article/09ef25d947814f0e8dc7f20690c9919c
Autor:
Shinji Goto, Maximillian A. Rogers, Mark C. Blaser, Hideyuki Higashi, Lang H. Lee, Florian Schlotter, Simon C. Body, Masanori Aikawa, Sasha A. Singh, Elena Aikawa
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 6 (2019)
Aortic valvular interstitial cells (VICs) isolated from patients undergoing valve replacement are commonly used as in vitro models of calcific aortic valve disease (CAVD). Standardization of VIC calcification, however, has not been implemented, which
Externí odkaz:
https://doaj.org/article/8d0ebe2ba483434c829b424833e89d23
Autor:
Carolina Roselli, Mengyao Yu, Victor Nauffal, Adrien Georges, Qiong Yang, Katie Love, Lu Chen Weng, Francesca N Delling, Svetlana R Maurya, Maren Schrölkamp, Jacob Tfelt-Hansen, Albert Hagège, Xavier Jeunemaitre, Stéphanie Debette, Philippe Amouyel, Wyliena Guan, Jochen D Muehlschlegel, Simon C Body, Svati Shah, Zainab Samad, Sergiy Kyryachenko, Carol Haynes, Michiel Rienstra, Thierry Le Tourneau, Vincent Probst, Ronan Roussel, Inez J Wijdh-Den Hamer, Joylene E Siland, Kirk U Knowlton, Jean Jacques Schott, Robert A Levine, Emelia J Benjamin, Ramachandran S Vasan, Benjamin D Horne, Joseph B Muhlestein, Giovanni Benfari, Maurice Enriquez-Sarano, Andrea Natale, Sanghamitra Mohanty, Chintan Trivedi, Moore B Shoemaker, Zachary T Yoneda, Quinn S Wells, Michael T Baker, Eric Farber-Eger, Hector I Michelena, Alicia Lundby, Russell A Norris, Susan A Slaugenhaupt, Christian Dina, Steven A Lubitz, Nabila Bouatia-Naji, Patrick T Ellinor, David J Milan
Publikováno v:
Eur Heart J
European Heart Journal, 43(17), 1668-1680. Oxford University Press
European Heart Journal, 43(17), 1668-1680. Oxford University Press
AIMS: Mitral valve prolapse (MVP) is a common valvular heart disease with a prevalence of >2% in the general adult population. Despite this high incidence, there is a limited understanding of the molecular mechanism of this disease, and no medical th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30eee9c44c658bdf1334d9d5447132ce
https://doi.org/10.1093/eurheartj/ehac049
https://doi.org/10.1093/eurheartj/ehac049