Single-cell transcriptomes and T cell receptors of vaccine-expanded apolipoprotein B-specific T cells

Autor: Felix Sebastian Nettersheim, Yanal Ghosheh, Holger Winkels, Kouji Kobiyama, Christopher Durant, Sujit Silas Armstrong, Simon Brunel, Payel Roy, Thamotharampillai Dileepan, Marc K. Jenkins, Dirk M. Zajonc, Klaus Ley

Publikováno v: Frontiers in Cardiovascular Medicine, Vol 9 (2023)

Atherosclerotic cardiovascular diseases are the major cause of death worldwide. CD4 T cells responding to Apolipoprotein B (ApoB), the core protein of most lipoproteins, have been identified as critical disease modulators. In healthy individuals, Apo

Externí odkaz: https://doaj.org/article/5fd88b680c23439d8fa156ff3f289073

Targeting the Human T-Cell Inducible COStimulator Molecule with a Monoclonal Antibody Prevents Graft-vs-Host Disease and Preserves Graft vs Leukemia in a Xenograft Murine Model

Autor: Aude Burlion, Simon Brunel, Nicolas Y. Petit, Daniel Olive, Gilles Marodon

Publikováno v: Frontiers in Immunology, Vol 8 (2017)

BackgroundGraft-vs-host disease (GVHD) is a major complication of allogenic bone marrow transplantation (BMT). Targeting costimulatory molecules with antagonist antibodies could dampen the excessive immune response that occurs, while preserving the b

Externí odkaz: https://doaj.org/article/f5b97b1f961e405c82050ab78594453b

Extracellular Vesicles Released by Allogeneic Human Cardiac Stem/Progenitor Cells as Part of Their Therapeutic Benefit

Autor: Armand Bensussan, Reem Al-Daccak, Qian Chen, Nabila Jabrane-Ferrat, Mabel San Roman, Simon Brunel, Yann J. Ferrat, Itziar Palacios, Jérôme Giustiniani, Eleuterio Lombardo, Olga de la Rosa, Dominique Charron, Hocine Rachid Hocine

Publikováno v: Stem Cells Translational Medicine
Stem Cells Translational Medicine, Wiley, 2019, ⟨10.1002/sctm.18-0256⟩
Stem Cells Translational Medicine, Vol 8, Iss 9, Pp 911-924 (2019)

The positive effects of therapeutic human allogeneic cardiac stem/progenitor cells (hCPC) in terms of cardiac repair/regeneration are very likely mediated by paracrine effects. Our previous studies revealed the advantageous immune interactions of all

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7628ee8dc115887fd3f2e57225e1cf1
https://doi.org/10.1002/sctm.18-0256

Late-rising CD4 T cells show dramatic control of cytomegalovirus persistence

Autor: Gaelle Genevieve Alice Picarda, Simon Brunel, Raima Ghosh, Ankan Gupta, Jason Greenbaum, Gregory Seumois, Michael Croft, Pandurangan Vijayanand, Chris A Benedict

Publikováno v: The Journal of Immunology. 204:247.2-247.2

Conventional CD4 T cells typically expand and establish memory pools within the first few weeks of acute viral infection. However, cytomegalovirus (CMV) exhibits an extended persistent replication phase followed by lifelong latency, suggesting the in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1952b38239d08de51039f6dc3c561c80
https://doi.org/10.4049/jimmunol.204.supp.247.2

Validation of the I.T50 method for assessing neuronal responsiveness to microiontophoretic applications: a single-cell recording study

Autor: Simon Brunel, Claude de Montigny

Publikováno v: Journal of pharmacological methods. 19(1)

The I.T50 method consists of determining the charge required to obtain a 50% depression of firing activity of neurons recorded extracellularly with microiontophoretic applications of inhibitory agents. This method has been used successfully to detect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8599c9806184b44cf958fb4088333fc3
https://pubmed.ncbi.nlm.nih.gov/3367646