Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Simon Brayford"'
Autor:
Simon Brayford, Alastair Duly, Wee Siang Teo, Tanya Dwarte, Estrella Gonzales‐Aloy, Zerong Ma, Laura McVeigh, Timothy W. Failes, Greg M. Arndt, Joshua A. McCarroll, Maria Kavallaris
Publikováno v:
Cancer Medicine, Vol 12, Iss 4, Pp 4455-4471 (2023)
Abstract Non‐Small Cell Lung Carcinoma (NSCLC) remains a leading cause of cancer death. Resistance to therapy is a significant problem, highlighting the need to find new ways of sensitising tumour cells to therapeutic agents. βIII‐tubulin is ass
Externí odkaz:
https://doaj.org/article/ca6480afb088470ca3e0c2a36817e4bf
Autor:
Ah-Lai Law, Shamsinar Jalal, Tommy Pallett, Fuad Mosis, Ahmad Guni, Simon Brayford, Lawrence Yolland, Stefania Marcotti, James A. Levitt, Simon P. Poland, Maia Rowe-Sampson, Anett Jandke, Robert Köchl, Giordano Pula, Simon M. Ameer-Beg, Brian Marc Stramer, Matthias Krause
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Cell migration is essential for many physiological processes. Its deregulation causes cancer metastasis and it is not well understood how it is tightly controlled. We identify NHSL1 as a negative regulator of actin nucleating Scar/WAVE-Arp2/3 complex
Externí odkaz:
https://doaj.org/article/5f81f0f7930346ea95298ce9f59b6d60
Autor:
Amelia L. Parker, Wee Siang Teo, Simon Brayford, Ullhas K. Moorthi, Senthil Arumugam, Charles Ferguson, Robert G. Parton, Joshua A. McCarroll, Maria Kavallaris
Publikováno v:
Cells, Vol 11, Iss 5, p 776 (2022)
βIII-tubulin is a neuronal microtubule protein that is aberrantly expressed in epithelial cancers. The microtubule network is implicated in regulating the architecture and dynamics of the mitochondrial network, although the isotype-specific role for
Externí odkaz:
https://doaj.org/article/8e2982ef91314d80a96294902b9f259a
Autor:
Maria Lastra Cagigas, Simon Brayford, Edna C. Hardeman, Nicole S. Bryce, Nicholas Ariotti, Peter W. Gunning
Publikováno v:
Nature Materials. 21:120-128
The actin cytoskeleton is the primary driver of cellular adhesion and mechanosensing due to its ability to generate force and sense the stiffness of the environment. At the cell’s leading edge, severing of the protruding Arp2/3 actin network genera
Autor:
Simon Brayford, Alastair Duly, Wee Siang Teo, Tanya Dwarte, Estrella Gonzales‐Aloy, Zerong Ma, Laura McVeigh, Timothy W. Failes, Greg M. Arndt, Joshua A. McCarroll, Maria Kavallaris
Publikováno v:
Cancer medicineREFERENCES.
Non-Small Cell Lung Carcinoma (NSCLC) remains a leading cause of cancer death. Resistance to therapy is a significant problem, highlighting the need to find new ways of sensitising tumour cells to therapeutic agents. βIII-tubulin is associated with
Autor:
Robert Köchl, Simon Brayford, Shamsinar Jalal, Simon Ameer-Beg, Fuad Mosis, Lawrence Yolland, Simon P. Poland, Maia Rowe-Sampson, Matthias Krause, Tommy Pallett, Ah-Lai Law, James A. Levitt, Stefania Marcotti, Ahmad Guni, Giordano Pula, Anett Jandke, Brian Stramer
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Cell migration is important for development and its aberrant regulation contributes to many diseases. The Scar/WAVE complex is essential for Arp2/3 mediated lamellipodia formation during mesenchymal cell migration and several coinciding signals activ
SummaryInteractions between different cell-types can induce distinct contact inhibition of locomotion (CIL) responses that are hypothesized to control population-wide behaviors during embryogenesis [1, 2]. However, our understanding of the signals th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e27f25943f0e0c91e02c0357c4ecd6f0
https://doi.org/10.1101/373696
https://doi.org/10.1101/373696
Autor:
Edna C. Hardeman, Galina Schevzov, James E. Bear, Nicole S. Bryce, Simon Brayford, Peter W. Gunning, Elizabeth M. Haynes
At the leading edge of migrating cells, protrusion of the lamellipodium is driven by Arp2/3-mediated polymerization of actin filaments [1]. This dense, branched actin network is promoted and stabilized by cortactin [2, 3]. In order to drive filament
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a2c5ab896a02722203022362378fdeb
Publikováno v:
The Cytoskeleton in Health and Disease ISBN: 9781493929030
The Cytoskeleton in Health and Disease, 373-391
STARTPAGE=373;ENDPAGE=391;TITLE=The Cytoskeleton in Health and Disease
The Cytoskeleton in Health and Disease, 373-391
STARTPAGE=373;ENDPAGE=391;TITLE=The Cytoskeleton in Health and Disease
The actin microfilament network is important for maintaining cell shape and function in eukaryotic cells. It has a multitude of roles in cellular processes such as cell adhesion, motility, cellular signalling, intracellular trafficking and cytokinesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7878edcc931840534422edbc8d504b47
https://doi.org/10.1007/978-1-4939-2904-7_16
https://doi.org/10.1007/978-1-4939-2904-7_16
Autor:
Simon, Brayford, Fiona N, Kenny, Toru, Hiratsuka, Eduardo, Serna-Morales, Lawrence, Yolland, Andrei, Luchici, Brian M, Stramer
Publikováno v:
Journal of Cell Science
Brayford, S, Kenny, F N, Hiratsuka, T, Serna Morales, E, Yolland, L, Luchici, A & Stramer, B M 2019, ' Heterotypic contact inhibition of locomotion can drive cell sorting between epithelial and mesenchymal cell populations ', Journal of Cell Science, vol. 132, no. 11, jcs223974 . https://doi.org/10.1242/jcs.223974
Brayford, S, Kenny, F N, Hiratsuka, T, Serna Morales, E, Yolland, L, Luchici, A & Stramer, B M 2019, ' Heterotypic contact inhibition of locomotion can drive cell sorting between epithelial and mesenchymal cell populations ', Journal of Cell Science, vol. 132, no. 11, jcs223974 . https://doi.org/10.1242/jcs.223974
Interactions between different cell types can induce distinct contact inhibition of locomotion (CIL) responses that are hypothesised to control population-wide behaviours during embryogenesis. However, our understanding of the signals that lead to ce