Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Simon Borna"'
Autor:
Imtissal Krayem, Srdjan Grusanovic, Iris Duric, Nataliia Pavliuchenko, Petr Danek, Simon Borna, Jarmila Sekeresova Kralova, Tereza Skopcova, Jana Pokorna, Meritxell Alberich-Jorda, Tomas Brdicka
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
WW domain binding protein 1-like (WBP1L), also known as outcome predictor of acute leukemia 1 (OPAL1), is a transmembrane adaptor protein, expression of which was shown to correlate with ETV6-RUNX1 translocation and favorable prognosis in childhood l
Externí odkaz:
https://doaj.org/article/12e8f8773e8a424cacafe4196414d790
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
The Chromosome 22q11.2 deletion syndrome (22q11.2DS) results in an inborn error of immunity due to defective thymic organogenesis. Immunological abnormalities in 22q11.2DS patients are thymic hypoplasia, reduced output of T lymphocytes by the thymus,
Externí odkaz:
https://doaj.org/article/38e8ce56c48441cb94f1152170109710
Publikováno v:
Frontiers in Genome Editing, Vol 5 (2023)
Clustered regularly interspaced short palindromic repeats (CRISPR) genome editing platform heralds a new era of gene therapy. Innovative treatments for life-threatening monogenic diseases of the blood and immune system are transitioning from semi-ran
Externí odkaz:
https://doaj.org/article/cf25462a05a24f5894038d6256bb07f3
Autor:
Mansi Narula, Uma Lakshmanan, Simon Borna, Janika J. Schulze, Tyson H. Holmes, Nicholas Harre, Matthew Kirkey, Akshaya Ramachandran, Veronica Maria Tagi, Federica Barzaghi, Eyal Grunebaum, Julia E.M. Upton, Vy Hong-Diep Kim, Christian Wysocki, Victoria R. Dimitriades, Kenneth Weinberg, Katja G. Weinacht, Yael Gernez, Bindu K. Sathi, Magdalena Schelotto, Matthew Johnson, Sven Olek, Christoph Sachsenmaier, Maria-Grazia Roncarolo, Rosa Bacchetta
Publikováno v:
The Journal of allergy and clinical immunology. 151(1)
Forkhead box protein 3 (FOXP3) is the master transcription factor in CD4We sought to study the type and extent of immunologic abnormalities that remain ill-defined in IPEX, across genetic and clinical heterogeneity.We performed Treg-cell-specific epi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b89fbdb16a8dec9dc59ba6458a6fdaa6
https://pubmed.ncbi.nlm.nih.gov/36152823
https://pubmed.ncbi.nlm.nih.gov/36152823
Publikováno v:
European journal of immunology. 52(5)
Immune dysregulation polyendocrinopathy enteropathy X linked (IPEX) syndrome is an uncurable disease of the immune system, with immune dysregulation that is caused by mutations in FOXP3. Current treatment options, such as pharmacological immune suppr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a12c9cfb77ffaa6f04a073c203c93e90
https://pubmed.ncbi.nlm.nih.gov/35355253
https://pubmed.ncbi.nlm.nih.gov/35355253
Early-onset pulmonary and cutaneous vasculitis driven by constitutively active SRC-family kinase HCK
Autor:
Jan Lebl, Eva Fronkova, Petr Novák, Tomas Brdicka, Marcela Dvorakova, Min Ae Lee-Kirsch, Jarmila Králová, Milan Macek, Ludmila Hornofova, Anna Sediva, Vendula Martinu, Jana Kayserova, Miroslav Koblizek, Michael Svaton, Petr Sedlacek, Ashleigh R Poh, Olga Zimmermannova, Ales Janda, Jana Paderova, Matthias Ernst, Tomas Kalina, Zuzana Parackova, Tamara Svobodová, Adam Klocperk, Stepanka Pruhova, Ondrej Hrusak, Veronika Kanderova, Simon Borna, Petr Pohunek, Martina Fejtkova
Background Inborn errors of immunity are genetic disorders characterized by various degrees of immune dysregulation that can manifest as immune deficiency, autoimmunity, or autoinflammation. The routine use of next-generation sequencing in the clinic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::661be0062cb1ee5200e3673fa2a750d8
Autor:
Tomas Brdicka, Orest V. Matveichuk, Majd B. Protty, Vladimir Korinek, Jana Pokorná, Ales Drobek, Veronika Kanderova, Nataliia Pavliuchenko, Simon Borna, Matej Fabisik, Daniela Glatzová, Michael G. Tomlinson, Katarzyna Kwiatkowska, Iva Splichalova, Pavla Angelisova, Julia Starkova, Jarmila Králová, Petr Stanek, Meritxell Alberich-Jorda, Tereza Skopcova
Publikováno v:
Journal of Cellular and Molecular Medicine
WW domain binding protein 1‐like (WBP1L), also known as outcome predictor of acute leukaemia 1 (OPAL1), is a transmembrane adaptor protein, expression of which correlates with ETV6‐RUNX1 (t(12;21)(p13;q22)) translocation and favourable prognosis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01ca4208dff1914e4fc5043fb2cc9d7d
http://europepmc.org/articles/PMC6991692
http://europepmc.org/articles/PMC6991692
Publikováno v:
J Biol Chem
Although signal transduction by immunoreceptors such as the T cell antigen receptor (TCR), B cell antigen receptor (BCR), and Fc receptors uses the same schematic and similar molecules, the threshold and the fine-tuning are set differently for each r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13866db7274fa1dd3ef488ccb434168f
https://europepmc.org/articles/PMC7489906/
https://europepmc.org/articles/PMC7489906/
Autor:
Ales Drobek, Tereza Skopcova, Pavel Kovarik, Jarmila Králová, Tomas Brdicka, Pavla Angelisova, Jan Prochazka, Jana Pokorná, Frantisek Spoutil, Simon Borna, Martin Gregor, Daniela Glatzová, Radislav Sedlacek
Autoinflammatory diseases are characterized by dysregulation of the innate immune system leading to spontaneous inflammation. Pstpip2cmo mouse strain is a well-characterized model of this class of disorders. Due to the mutation leading to the lack of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19ff13883a95ef4b6c0a329b554fb6c5
https://doi.org/10.1101/727222
https://doi.org/10.1101/727222
Publikováno v:
Journal of Visualized Experiments.
Dendritic cells and macrophages are crucial cells that form the first line of defense against pathogens. They also play important roles in the initiation of an adaptive immune response. Experimental work with these cells is rather challenging. Their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14e201a5f21c53a3c9a1c629f6357175
https://doi.org/10.3791/58081-v
https://doi.org/10.3791/58081-v