Zobrazeno 1 - 10 of 10 pro vyhledávání: '"Simon Bohleber"'
1
Akademický článek
Alterations in gonadotropin, apoptotic and metabolic pathways in granulosa cells warrant superior fertility of the Dummerstorf high fertility mouse line 1
Autor: Carolin Lisa Michaela Ludwig, Simon Bohleber, Rebecca Lapp, Alexander Rebl, Eva Katrin Wirth, Martina Langhammer, Ulrich Schweizer, Joachim M. Weitzel, Marten Michaelis
Publikováno v: Journal of Ovarian Research, Vol 16, Iss 1, Pp 1-16 (2023)
Abstract The development and maturation of ovarian follicles is a complex and highly regulated process, which is essential for successful ovulation. During recent decades, several mouse models provided insights into the regulation of folliculogenesis
Externí odkaz: https://doaj.org/article/0c473caab59c408e9f2bc99bc4e46ba8
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2
Akademický článek
Missense mutation in selenocysteine synthase causes cardio-respiratory failure and perinatal death in mice which can be compensated by selenium-independent GPX4
Autor: Noelia Fradejas-Villar, Wenchao Zhao, Uschi Reuter, Michael Doengi, Irina Ingold, Simon Bohleber, Marcus Conrad, Ulrich Schweizer
Publikováno v: Redox Biology, Vol 48, Iss , Pp 102188- (2021)
Selenoproteins are a small family of proteins containing the trace element selenium in form of the rare amino acid selenocysteine (Sec), which is decoded by the UGA codon. In humans, a number of pathogenic variants in genes encoding distinct selenopr
Externí odkaz: https://doaj.org/article/f6302178548c423e8a2aad1b6790908b
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3
Akademický článek
High-Resolution Ribosome Profiling Reveals Gene-Specific Details of UGA Re-Coding in Selenoprotein Biosynthesis
Autor: Simon Bohleber, Noelia Fradejas-Villar, Wenchao Zhao, Uschi Reuter, Ulrich Schweizer
Publikováno v: Biomolecules, Vol 12, Iss 10, p 1504 (2022)
Co-translational incorporation of selenocysteine (Sec) into selenoproteins occurs at UGA codons in a process in which translational elongation competes with translational termination. Selenocysteine insertion sequence-binding protein 2 (SECISBP2) gre
Externí odkaz: https://doaj.org/article/4504362c517646c2b171a7b89b608e6c
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4
Akademický článek
The Neurobiology of Selenium: Looking Back and to the Future
Autor: Ulrich Schweizer, Simon Bohleber, Wenchao Zhao, Noelia Fradejas-Villar
Publikováno v: Frontiers in Neuroscience, Vol 15 (2021)
Eighteen years ago, unexpected epileptic seizures in Selenop-knockout mice pointed to a potentially novel, possibly underestimated, and previously difficult to study role of selenium (Se) in the mammalian brain. This mouse model was the key to open t
Externí odkaz: https://doaj.org/article/aa812168596d4f91b318c6c333a56aa7
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6
Missense mutation in selenocysteine synthase causes cardio-respiratory failure and perinatal death in mice which can be compensated by selenium-independent GPX4
Autor: Simon Bohleber, Ulrich Schweizer, Irina Ingold, Michael Doengi, Wenchao Zhao, Uschi Reuter, Noelia Fradejas-Villar, Marcus Conrad
Publikováno v: Redox Biology
Redox Biol. 48:102188 (2021)
Redox Biology, Vol 48, Iss, Pp 102188-(2021)
Selenoproteins are a small family of proteins containing the trace element selenium in form of the rare amino acid selenocysteine (Sec), which is decoded by the UGA codon. In humans, a number of pathogenic variants in genes encoding distinct selenopr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50a88a1e07744572f91dce104337c05a
https://pubmed.ncbi.nlm.nih.gov/34794077
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7
The Effect of tRNA
Autor: Tsutomu Suzuki, Uschi Reuter, Noelia Fradejas-Villar, Wenchao Zhao, Kenjyo Miyauchi, Rainer Knoll, Robert McFarland, Mark Helm, Simon Bohleber, Robert W. Taylor, Yuriko Sakaguchi, Annika Kotter, Ulrich Schweizer, Yufeng Mo
Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 21
International Journal of Molecular Sciences, Vol 22, Iss 11454, p 11454 (2021)
Transfer RNA[Ser]Sec carries multiple post-transcriptional modifications. The A37G mutation in tRNA[Ser]Sec abrogates isopentenylation of base 37 and has a profound effect on selenoprotein expression in mice. Patients with a homozygous pathogenic p.R
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1967639b9aa4e7dc4adf45688eabfdd0
https://pubmed.ncbi.nlm.nih.gov/34768885
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8
Ribosome profiling of selenoproteins in vivo reveals consequences of pathogenic Secisbp2 missense mutations
Autor: Uschi Reuter, Doreen Braun, Ulrich Schweizer, Michael T. Howard, Simon Bohleber, Sandra Seeher, Wenchao Zhao, S. Arndt, Hagen Wende, Carmen Birchmeier, Henrik Schmidt, Noelia Fradejas-Villar
Publikováno v: Journal of Biological Chemistry. 294:14185-14200
Recoding of UGA codons as selenocysteine (Sec) codons in selenoproteins depends on a selenocysteine insertion sequence (SECIS) in the 3′-UTR of mRNAs of eukaryotic selenoproteins. SECIS-binding protein 2 (SECISBP2) increases the efficiency of this
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07196a118cf06c0610784e167c04ffba
https://doi.org/10.1074/jbc.ra119.009369
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10
The modified base isopentenyladenosine and its derivatives in tRNA
Autor: Ulrich Schweizer, Simon Bohleber, Noelia Fradejas-Villar
Publikováno v: RNA Biology
Base 37 in tRNA, 3′-adjacent to the anticodon, is occupied by a purine base that is thought to stabilize codon recognition by stacking interactions on the first Watson-Crick base pair. If the first codon position forms an A.U or U.A base pair, the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f1f5003f76f3eaa457bac0c69cd4356
https://doi.org/10.1080/15476286.2017.1294309
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