Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Simon Bernèche"'
Autor:
Sophie Roy, Niklaus Johner, Viktor Trendafilov, Ivan Gautschi, Olivier Bignucolo, Ophélie Molton, Simon Bernèche, Stephan Kellenberger
Publikováno v:
Open Biology, Vol 12, Iss 12 (2022)
The extracellular Ca2+ concentration changes locally under certain physiological and pathological conditions. Such variations affect the function of ion channels of the nervous system and consequently also neuronal signalling. We investigated here th
Externí odkaz:
https://doaj.org/article/555c8ce8e3da400bb0f217a5277dac57
Autor:
Olivier Bignucolo, Simon Bernèche
Publikováno v:
Frontiers in Molecular Biosciences, Vol 7 (2020)
Voltage-gated potassium channels (Kv) allow ion permeation upon changes of the membrane electrostatic potential (Vm). Each subunit of these tetrameric channels is composed of six transmembrane helices, of which the anti-parallel helix bundle S1-S4 co
Externí odkaz:
https://doaj.org/article/b30e376deb0e43eaa35feacee44aba7e
Autor:
Lilia Leisle, Yanyan Xu, Eva Fortea, Sangyun Lee, Jason D Galpin, Malvin Vien, Christopher A Ahern, Alessio Accardi, Simon Bernèche
Publikováno v:
eLife, Vol 9 (2020)
The CLC family comprises H+-coupled exchangers and Cl- channels, and mutations causing their dysfunction lead to genetic disorders. The CLC exchangers, unlike canonical 'ping-pong' antiporters, simultaneously bind and translocate substrates through p
Externí odkaz:
https://doaj.org/article/c9ee0e91e4b94b3f972f512b0980c861
Publikováno v:
ACS Central Science, Vol 3, Iss 3, Pp 250-258 (2017)
Externí odkaz:
https://doaj.org/article/06a993b3d8844f91b9a8018d565769f8
Autor:
Maximilian M. Sauer, Roman P. Jakob, Jonathan Eras, Sefer Baday, Deniz Eriş, Giulio Navarra, Simon Bernèche, Beat Ernst, Timm Maier, Rudi Glockshuber
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Catch bonds have a role in bacterial adhesion and infection by uropathogenic E. coli.Here, the authors report crystal structures, molecular dynamics simulations, ligand binding analysis and cell tracking to characterise the catch bond interaction bet
Externí odkaz:
https://doaj.org/article/15996d3b67454979a441ce96b98b7d26
Publikováno v:
eLife, Vol 6 (2017)
Potassium channels are opened by ligands and/or membrane potential. In voltage-gated K+ channels and the prokaryotic KcsA channel, conduction is believed to result from opening of an intracellular constriction that prevents ion entry into the pore. O
Externí odkaz:
https://doaj.org/article/401d53a3f00a424abd5f848f51324858
Autor:
Simon Bernèche, Eva Fortea, Sangyun Lee, Alessio Accardi, Jason D. Galpin, Malvin Vien, Lilia Leisle, Christopher A. Ahern, Yanyan Xu
Publikováno v:
eLife, Vol 9 (2020)
eLife 9, e51224 (2020). doi:10.7554/eLife.51224
eLife 9, e51224 (2020). doi:10.7554/eLife.51224
The CLC family comprises H; +; -coupled exchangers and Cl; -; channels, and mutations causing their dysfunction lead to genetic disorders. The CLC exchangers, unlike canonical 'ping-pong' antiporters, simultaneously bind and translocate substrates th
Autor:
Simon Bernèche, Olivier Bignucolo
Publikováno v:
Frontiers in Molecular Biosciences
Frontiers in molecular biosciences, vol. 7, pp. 162
Frontiers in Molecular Biosciences, Vol 7 (2020)
Frontiers in molecular biosciences, vol. 7, pp. 162
Frontiers in Molecular Biosciences, Vol 7 (2020)
Voltage-gated potassium channels (Kv) allow ion permeation upon changes of the membrane electrostatic potential (Vm). Each subunit of these tetrameric channels is composed of six transmembrane helices, of which the anti-parallel helix bundle S1-S4 co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a9fa701ea5a22b64dc63c034752b630
Autor:
Sabrina Vullo, Gaetano Bonifacio, Niklaus Johner, Stephan Kellenberger, Sophie Roy, Simon Bernèche
Publikováno v:
Proceedings of the National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America, vol. 114, no. 14, pp. 3768-3773
Proceedings of the National Academy of Sciences of the United States of America, vol. 114, no. 14, pp. 3768-3773
Acid-sensing ion channels (ASICs) are proton-activated Na + channels expressed in the nervous system, where they are involved in learning, fear behaviors, neurodegeneration, and pain sensation. In this work, we study the role in pH sensing of two reg