Zobrazeno 1 - 10
of 145
pro vyhledávání: '"Simon Arnett"'
Autor:
Laura Clarke, Simon Arnett, Wajih Bukhari, Elham Khalilidehkordi, Sofia Jimenez Sanchez, Cullen O'Gorman, Jing Sun, Kerri M. Prain, Mark Woodhall, Roger Silvestrini, Christine S. Bundell, David A. Abernethy, Sandeep Bhuta, Stefan Blum, Mike Boggild, Karyn Boundy, Bruce J. Brew, Wallace Brownlee, Helmut Butzkueven, William M. Carroll, Cella Chen, Alan Coulthard, Russell C. Dale, Chandi Das, Marzena J. Fabis-Pedrini, David Gillis, Simon Hawke, Robert Heard, Andrew P. D. Henderson, Saman Heshmat, Suzanne Hodgkinson, Trevor J. Kilpatrick, John King, Christopher Kneebone, Andrew J. Kornberg, Jeannette Lechner-Scott, Ming-Wei Lin, Christopher Lynch, Richard A. L. Macdonell, Deborah F. Mason, Pamela A. McCombe, Jennifer Pereira, John D. Pollard, Sudarshini Ramanathan, Stephen W. Reddel, Cameron P. Shaw, Judith M. Spies, James Stankovich, Ian Sutton, Steve Vucic, Michael Walsh, Richard C. Wong, Eppie M. Yiu, Michael H. Barnett, Allan G. K. Kermode, Mark P. Marriott, John D. E. Parratt, Mark Slee, Bruce V. Taylor, Ernest Willoughby, Fabienne Brilot, Angela Vincent, Patrick Waters, Simon A. Broadley
Publikováno v:
Frontiers in Neurology, Vol 12 (2021)
Neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis (MS) are inflammatory diseases of the CNS. Overlap in the clinical and MRI features of NMOSD and MS means that distinguishing these conditions can be difficult. With the aim of eva
Externí odkaz:
https://doaj.org/article/9881dfe6e71f44f48b35ffd764478289
Autor:
Elham Khalilidehkordi, Laura Clarke, Simon Arnett, Wajih Bukhari, Sofia Jimenez Sanchez, Cullen O'Gorman, Jing Sun, Kerri M. Prain, Mark Woodhall, Roger Silvestrini, Christine S. Bundell, David Abernethy, Sandeep Bhuta, Stefan Blum, Mike Boggild, Karyn Boundy, Bruce J. Brew, Matthew Brown, Wallace Brownlee, Helmut Butzkueven, William M. Carroll, Celia Chen, Alan Coulthard, Russell C. Dale, Chandi Das, Marzena J. Fabis-Pedrini, David Fulcher, David Gillis, Simon Hawke, Robert Heard, Andrew P. D. Henderson, Saman Heshmat, Suzanne Hodgkinson, Trevor J. Kilpatrick, John King, Chris Kneebone, Andrew J. Kornberg, Jeannette Lechner-Scott, Ming-Wei Lin, Christopher Lynch, Richard A. L. Macdonell, Deborah F. Mason, Pamela A. McCombe, Jennifer Pereira, John D. Pollard, Sudarshini Ramanathan, Stephen W. Reddel, Cameron Shaw, Judith Spies, James Stankovich, Ian Sutton, Steve Vucic, Michael Walsh, Richard C. Wong, Eppie M. Yiu, Michael H. Barnett, Allan G. Kermode, Mark P. Marriott, John Parratt, Mark Slee, Bruce V. Taylor, Ernest Willoughby, Fabienne Brilot, Angela Vincent, Patrick Waters, Simon A. Broadley
Publikováno v:
Frontiers in Neurology, Vol 11 (2020)
Neuromyelitis optica spectrum disorders (NMOSD) and multiple sclerosis (MS) show overlap in their clinical features. We performed an analysis of relapses with the aim of determining differences between the two conditions. Cases of NMOSD and age- and
Externí odkaz:
https://doaj.org/article/9368fd0e4b594e0a86dbfe7d5222074a
Publikováno v:
Clin Exp Immunol
Neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory disease of the central nervous system (CNS) associated with antibodies to aquaporin-4 (AQP4), which has distinct clinical, radiological and pathological features, but also has some ove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cb044a1ff47e5e1696002eca6fdc1c5
https://doi.org/10.1111/cei.13630
https://doi.org/10.1111/cei.13630
Publikováno v:
Frontiers in Immunology, Vol 7 (2016)
Tertiary lymphoid organs (TLOs) are frequently observed in tissues affected by non-resolving inflammation as a result of infection, autoimmunity, cancer and allograft rejection. These highly ordered structures resemble the cellular composition of lym
Externí odkaz:
https://doaj.org/article/eb45dbcacd4d44c799f359a7a68abc45
Autor:
Christine Dambietz, Mohammad Reza Ahmadian, Radovan Dvorsky, Alicia Derrac Soria, Anna F. Berg, Selina Hansen, Denise Heise, Jürgen Scheller, Georg H. Waetzig, Jens M. Moll, Simon Arnett Jones, Mohammad Akbarzadeh
The cytokine interleukin-6 (IL-6) signals through three mechanisms called classic signaling, trans-signaling, and trans-presentation. IL-6 trans-signaling is distinctly mediated through a soluble form of its transmembrane receptor IL-6R (sIL-6R) and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9924693829d28e936832569669c2a617
Publikováno v:
Nature Reviews. Immunology
The identification of elevated IL-6 levels in patients with severe COVID-19 led to the rapid development of clinical trials targeting this cytokine. Overall, these trials do not support the widespread use of IL-6 antagonists in hospitalized patients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6af6909ebef4dd482e9266c8524fcaaf
Publikováno v:
Cytokine. 148
The classification of interleukin-6 (IL-6) as a pro-inflammatory cytokine undervalues the biological impact of this cytokine in health and disease. With broad activities affecting the immune system, tissue homeostasis and metabolic processes, IL-6 di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afa6324e803b3970f5c15092e8e57346
https://pubmed.ncbi.nlm.nih.gov/34411990
https://pubmed.ncbi.nlm.nih.gov/34411990
Autor:
Thomas W.H. Kay, Yew Ann Leong, Tony Tiganis, Pei Kee Goh, Di Yu, Thomas C. Brodnicki, Florian Wiede, Simon Arnett Jones, Gareth W. Jones, Alan G. Baxter
Publikováno v:
Wiede, F, Brodnicki, T C, Goh, P K, Leong, Y A, Jones, G W, Yu, D, Baxter, A G, Jones, S A, Kay, T W H & Tiganis, T 2019, ' T Cell-Specific PTPN2-Deficiency in NOD Mice Accelerates the Development of Type 1 Diabetes and Autoimmune Co-Morbidities. ', Diabetes, vol. 68, no. 6, pp. 1251-1266 . https://doi.org/10.2337/db18-1362
Genome-wide association studies have identified PTPN2 as an important non-major histocompatibility complex gene for autoimmunity. Single nucleotide polymorphisms that reduce PTPN2 expression have been linked with the development of varied autoimmune
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::836d1e5aa9374a049544b3fd56dd6dfa
https://doi.org/10.2337/db18-1362
https://doi.org/10.2337/db18-1362
Autor:
Simon Arnett Jones, Jasmine Li, Florian Wiede, Michael J. Townsend, Gareth W. Jones, Xiao Liu, Costantino Pitzalis, Robert Andrews, Jason Peter Twohig, Alicia Derrac Soria, Philip R. Taylor, Javier Uceda Fernandez, Tony Tiganis, Barbara Szomolay, David Hill, Myles Lewis, Chris Pepper, Benjamin C. Cossins, Nigel Williams, Ana Cardus Figueras, David Millrine
Publikováno v:
Twohig, J, Figueras, A C, Andrews, R, Wiede, F, Cossins, B, Soria, A D, Lewis, M, Townsend, M, Millrine, D, Hill, D, Fernandez, J U, Liu, X, Szomolay, B, Pepper, C, Taylor, P, Pitzalis, C, Tiganis, T, Williams, N, Jones, G, Jones, S & Li, J 2019, ' Activation of naïve CD4 + T cells re-tunes STAT1 signaling to deliver unique cytokine responses in memory CD4 + T cells ', Nature Immunology, vol. 20, no. 4, pp. 458-470 . https://doi.org/10.1038/s41590-019-0350-0
The cytokine IL-6 controls the survival, proliferation and effector characteristics of lymphocytes through activation of the transcription factors STAT1 and STAT3. While STAT3 activity is an ever-present feature of IL-6 signaling in CD4 + T cells, pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08f2d84d1e02e30b242a82730c030eed
https://doi.org/10.1038/s41590-019-0350-0
https://doi.org/10.1038/s41590-019-0350-0
Publikováno v:
Function (Oxford, England). 2(1)
No abstract available.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::208b9750d9b794fa1fc5c2297cba27a6
https://pubmed.ncbi.nlm.nih.gov/35330968
https://pubmed.ncbi.nlm.nih.gov/35330968