8-oxoguanine forms quartets with a large central cavity

Autor: Simon Aleksič, Peter Podbevšek, Janez Plavec

Publikováno v: Biochemistry, vol. 61, no. 21, 2022.
Biochemistry, str. 2390–2397 : Ilustr., Vol. 61, iss. 21, 1 Nov. 2022
COBISS-ID: 19197991
Biochemistry

Oxidation of a guanine nucleotide in DNA yields an 8-oxoguanine nucleotide ($^{oxo}$G) and is a mutagenic event in the genome. Due to different arrangements of hydrogen-bond donors and acceptors, $^{oxo}$G can affect the secondary structure of nuclei

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