Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Simon A. Sharples"'
Autor:
Simon A. Sharples, Jessica Parker, Alex Vargas, Jonathan J. Milla-Cruz, Adam P. Lognon, Ning Cheng, Leanne Young, Anchita Shonak, Gennady S. Cymbalyuk, Patrick J. Whelan
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2022)
Developing spinal motor networks produce a diverse array of outputs, including episodic and continuous patterns of rhythmic activity. Variation in excitability state and neuromodulatory tone can facilitate transitions between episodic and continuous
Externí odkaz:
https://doaj.org/article/747aa073fb3f4e11a9b95496b04eadd5
Integration of Descending Command Systems for the Generation of Context-Specific Locomotor Behaviors
Autor:
Linda H. Kim, Sandeep Sharma, Simon A. Sharples, Kyle A. Mayr, Charlie H. T. Kwok, Patrick J. Whelan
Publikováno v:
Frontiers in Neuroscience, Vol 11 (2017)
Over the past decade there has been a renaissance in our understanding of spinal cord circuits; new technologies are beginning to provide key insights into descending circuits which project onto spinal cord central pattern generators. By integrating
Externí odkaz:
https://doaj.org/article/01022b7774314325a6f93ec341720c07
Autor:
Simon A Sharples, Gareth B Miles
Publikováno v:
eLife, Vol 10 (2021)
The size principle underlies the orderly recruitment of motor units; however, motoneuron size is a poor predictor of recruitment amongst functionally defined motoneuron subtypes. Whilst intrinsic properties are key regulators of motoneuron recruitmen
Externí odkaz:
https://doaj.org/article/4a3a71971e474a5dae760a339c442ef8
Autor:
Simon A Sharples, Patrick J Whelan
Publikováno v:
eLife, Vol 7 (2018)
A subgroup of the neurons that control muscles becomes less excitable shortly before the symptoms of ALS develop.
Externí odkaz:
https://doaj.org/article/6a2890250ec8446a9e2a5e045667e092
Autor:
Panagiotis E. Eleftheriadis, Konstantinos Pothakos, Simon A. Sharples, Panagiota E. Apostolou, Maria Mina, Efstathia Tetringa, Gareth B. Miles, Laskaro Zagoraiou
The intensity of muscle contraction, and therefore movement vigour, needs to be adaptable to enable complex motor behaviors. This can be achieved by adjusting the properties of motor neurons, which form the final common pathway for all motor output f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81090bc9625d7cd82f61a27c7103c797
https://doi.org/10.1101/2022.11.05.515234
https://doi.org/10.1101/2022.11.05.515234
Autor:
Simon A, Sharples, Jessica, Parker, Alex, Vargas, Jonathan J, Milla-Cruz, Adam P, Lognon, Ning, Cheng, Leanne, Young, Anchita, Shonak, Gennady S, Cymbalyuk, Patrick J, Whelan
Publikováno v:
Frontiers in cellular neuroscience. 15
Developing spinal motor networks produce a diverse array of outputs, including episodic and continuous patterns of rhythmic activity. Variation in excitability state and neuromodulatory tone can facilitate transitions between episodic and continuous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::55a0842f70156e817b80db66d5c1c5bb
https://pubmed.ncbi.nlm.nih.gov/35185470
https://pubmed.ncbi.nlm.nih.gov/35185470
Autor:
Tuan Trang, Céline Jean-Xavier, Simon A. Sharples, Joanna Borowska-Fielding, Shane E. A. Eaton, Ying Zhang, Nicole E. Burma, Charlie H.T. Kwok, Patrick J. Whelan, Glen B. Baker
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-23 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-23 (2020)
Dopamine is well known to regulate movement through the differential control of direct and indirect pathways in the striatum that express D1 and D2 receptors respectively. The spinal cord also expresses all dopamine receptors however; how the specifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a6a70c1d76fa1e5ad95a164839e3852
https://hdl.handle.net/10023/20730
https://hdl.handle.net/10023/20730
Autor:
Ning Cheng, Adam P. Lognon, Jessica Parker, Leanne Young, Gennady Cymbalyuk, Patrick J. Whelan, Alex Vargas, Anchita Shonak, Simon A. Sharples
Developing spinal motor networks produce a diverse array of outputs, including episodic and continuous patterns of rhythmic activity. Variation in excitability state and neuromodulatory tone can facilitate transitions between episodic and continuous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ac4ecb7175fa93070bcd503fc8ae965
https://doi.org/10.1101/2020.09.08.288266
https://doi.org/10.1101/2020.09.08.288266
Autor:
Simon A. Sharples, Patrick J. Whelan
Over the last decade, there has been a resurgence of work using mammalian systems in vivo. We build on the idea that there were three pillars of motor control built on invertebrate and vertebrate models. We discuss the translational aspect of animal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53786126f75830932500868870f3d824
https://doi.org/10.1016/b978-0-12-816477-8.00016-8
https://doi.org/10.1016/b978-0-12-816477-8.00016-8