Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Simon A. McManus"'
Autor:
Kurt D. Ristroph, Jie Feng, Simon A. McManus, Yingyue Zhang, Kai Gong, Hanu Ramachandruni, Claire E. White, Robert K. Prud’homme
Publikováno v:
Journal of Translational Medicine, Vol 17, Iss 1, Pp 1-12 (2019)
Abstract Background OZ439 is a new chemical entity which is active against drug-resistant malaria and shows potential as a single-dose cure. However, development of an oral formulation with desired exposure has proved problematic, as OZ439 is poorly
Externí odkaz:
https://doaj.org/article/ef1329c7cb35484c95cf063ea6909023
Autor:
Simon A. McManus, Yingyue Zhang, Bumjun Kim, Byung Kook Lee, Mohamed E.H. ElSayed, Robert K. Prud'homme
Publikováno v:
Precision Nanomedicine, Vol 3, Iss 4 (2020)
We describe inverse-Flash NanoPrecipitation as a new scalable platform for co-encapsulation of insulin (a model therapeutic peptide) with soybean trypsin inhibitor (a peptidase inhibitor) and so-dium caprate (a permeation enhancer) forming 300 nm par
Externí odkaz:
https://doaj.org/article/c13d4c5be9914f7b85c8205cb9f6ade2
Autor:
Simon A. McManus, Yingfu Li
Publikováno v:
Molecules, Vol 15, Iss 9, Pp 6269-6284 (2010)
When not constrained to long double-helical arrangements, DNA is capable of forming structural arrangements that enable specific sequences to perform functions such as binding and catalysis under defined conditions. Through a process called in vitro
Externí odkaz:
https://doaj.org/article/7e7f35a629724e49a162cc535aad68ae
Autor:
Simon A. McManus, Andrew J. Clulow, Adrian Hawley, Ben J. Boyd, Gisela Ramirez, Kurt D. Ristroph, Robert K. Prud'homme, Jie Feng, Malinda Salim, Yingyue Zhang
Publikováno v:
Molecular Pharmaceutics. 16:2755-2765
[Image: see text] Clofazimine, a drug previously used to treat leprosy, has recently been identified as a potential new drug for the treatment for cryptosporidiosis: a diarrheal disease that contributes to 500 000 infant deaths a year in developing c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75f1c1732c63fe32137cd8204e0717f1
https://doi.org/10.1021/acs.molpharmaceut.9b00276
https://doi.org/10.1021/acs.molpharmaceut.9b00276
Autor:
Kurt D. Ristroph, Simon A. McManus, Gauri Shetye, Sang Hyun Cho, Dennis Lee, Zoltan Szekely, Patrick J. Sinko, Scott G. Franzblau, Robert K. Prud'homme
Publikováno v:
Advanced Materials Technologies. 7:2101748
The encapsulation of therapeutics into nanocarriers with specialized surface chemistries for targeting applications in the body is a major goal in the field of drug delivery. Here the encapsulation of an antitubercular peptide, ecumicin, into monodis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa0620b286e38b14a84b4a010ef21757
https://doi.org/10.1002/admt.202101748
https://doi.org/10.1002/admt.202101748
Autor:
Kurt D. Ristroph, Anil Patel, Jie Feng, William D. Mulhearn, Simon A. McManus, Ellen L K Dobrijevic, Hoang D. Lu, Robert K. Prud'homme, Hanu Ramachandruni, Yingyue Zhang
Publikováno v:
ACS Infectious Diseases
Malaria poses a major burden on human health and is becoming increasingly difficult to treat due to the development of antimalarial drug resistance. The resistance issue is further exacerbated by a lack of patient adherence to multi-day dosing regime
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a849ebea202473306e4a67abca130f7
https://doi.org/10.1021/acsinfecdis.7b00278
https://doi.org/10.1021/acsinfecdis.7b00278
Autor:
Prashanth K. Padakanti, Simon A. McManus, Jenny Jumai’an, Robert H. Mach, Leon Z. Wang, Brian K. Wilson, Abass Alavi, Hoang D. Lu, Robert K. Prud'homme
Publikováno v:
ACS Applied Materials & Interfaces. 10:3191-3199
Nanoparticles (NP) are promising contrast agents for positron emission tomography (PET) radionuclide imaging that can increase signal intensity by localizing clusters of PET radionuclides together. However, methods to load NPs with PET radionuclides
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ab26cd1de49791f4d4ca0ee5929dffc
https://doi.org/10.1021/acsami.7b07242
https://doi.org/10.1021/acsami.7b07242
Autor:
Joseph Bteich, Mark J. Ernsting, Mohammed Mohammed, Simon A. McManus, Kenneth K. Sokoll, Robert K. Prud'homme
Publikováno v:
Molecular Pharmaceutics. 14:3998-4007
We report the use of flash nanoprecipitation (FNP) as an efficient and scalable means of producing Cellax nanoparticles. Cellax polymeric conjugates consisting of carboxymethyl cellulose functionalized with PEG and hydrophobic anticancer drugs, such
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5b4ea616d2824edb29afc79bb12515e
https://doi.org/10.1021/acs.molpharmaceut.7b00670
https://doi.org/10.1021/acs.molpharmaceut.7b00670
Amorphous nanoparticles by self-assembly: processing for controlled release of hydrophobic molecules
Autor:
Jie, Feng, Yingyue, Zhang, Simon A, McManus, Rolane, Qian, Kurt D, Ristroph, Hanu, Ramachandruni, Kai, Gong, Claire E, White, Aditya, Rawal, Robert K, Prud'homme
Publikováno v:
Soft matter. 15(11)
More than 40% of newly developed drug molecules are highly hydrophobic and, thus, suffer from low bioavailability. Kinetically trapping the drug as a nanoparticle in an amorphous state enhances solubility. However, enhanced solubility can be compromi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::643cf15b03e9dfe68f4d07d3d7128bb5
https://pubmed.ncbi.nlm.nih.gov/30776040
https://pubmed.ncbi.nlm.nih.gov/30776040
Autor:
Robert K. Prud'homme, Kurt D. Ristroph, Jie Feng, Yingyue Zhang, Claire E. White, Hanu Ramachandruni, Kai Gong, Simon A. McManus
Publikováno v:
Journal of Translational Medicine
Journal of Translational Medicine, Vol 17, Iss 1, Pp 1-12 (2019)
Journal of Translational Medicine, Vol 17, Iss 1, Pp 1-12 (2019)
Background OZ439 is a new chemical entity which is active against drug-resistant malaria and shows potential as a single-dose cure. However, development of an oral formulation with desired exposure has proved problematic, as OZ439 is poorly soluble (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a34041eff7a2cb5bd65d1dd47b8b1e91
https://pubmed.ncbi.nlm.nih.gov/30902103
https://pubmed.ncbi.nlm.nih.gov/30902103