Zobrazeno 1 - 10
of 119
pro vyhledávání: '"Simon A. Johnston"'
Autor:
Charlotte E. Moss, Simon A. Johnston, Joshua V. Kimble, Martha Clements, Veryan Codd, Stephen Hamby, Alison H. Goodall, Sumeet Deshmukh, Ian Sudbery, Daniel Coca, Heather L. Wilson, Endre Kiss-Toth
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 114073- (2024)
Summary: Macrophages are central innate immune cells whose function declines with age. The molecular mechanisms underlying age-related changes remain poorly understood, particularly in human macrophages. We report a substantial reduction in phagocyto
Externí odkaz:
https://doaj.org/article/4b1acb9fd5b841acafd7c00ff65e1ec6
Autor:
Laura Martinez-Campesino, Klaudia Kocsy, Jaime Cañedo, Jessica M. Johnston, Charlotte E. Moss, Simon A. Johnston, Stephen Hamby, Alison H. Goodall, Jessica Redgrave, Sheila E. Francis, Endre Kiss-Toth, Heather L. Wilson
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
Tribbles 3 (TRIB3) modulates lipid and glucose metabolism, macrophage lipid uptake, with a gain-of-function variant associated with increased cardiovascular risk. Here we set out to examine the role of this pseudokinase in atherosclerotic plaque deve
Externí odkaz:
https://doaj.org/article/1df53f81336a40e38b43f7c0fbff1e15
Autor:
Josie F. Gibson, Aleksandra Bojarczuk, Robert J. Evans, Alfred Alinafe Kamuyango, Richard Hotham, Anne K. Lagendijk, Benjamin M. Hogan, Philip W. Ingham, Stephen A. Renshaw, Simon A. Johnston
Publikováno v:
PLoS Pathogens, Vol 18, Iss 4 (2022)
Meningitis caused by infectious pathogens is associated with vessel damage and infarct formation, however the physiological cause is often unknown. Cryptococcus neoformans is a human fungal pathogen and causative agent of cryptococcal meningitis, whe
Externí odkaz:
https://doaj.org/article/9a0f3facc19348eb8e32b4c945c9e636
Autor:
Lucian Duvenage, Louise A. Walker, Aleksandra Bojarczuk, Simon A. Johnston, Donna M. MacCallum, Carol A. Munro, Campbell W. Gourlay
Publikováno v:
mBio, Vol 10, Iss 1 (2019)
ABSTRACT The human fungal pathogen Candida albicans requires respiratory function for normal growth, morphogenesis, and virulence. Mitochondria therefore represent an enticing target for the development of new antifungal strategies. This possibility
Externí odkaz:
https://doaj.org/article/d09b6a0106be494e92b07724b0b9b1ca
Autor:
Rhys A. Watkins, Alexandre Andrews, Charlotte Wynn, Caroline Barisch, Jason S. King, Simon A. Johnston
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 8 (2018)
Cryptococcus neoformans is an environmental yeast that can cause opportunistic infections in humans. As infecting animals does not form part of its normal life-cycle, it has been proposed that the virulence traits that allow cryptococci to resist imm
Externí odkaz:
https://doaj.org/article/da1ff1fc9a3249a8909e2adea9045c2a
Publikováno v:
Microorganisms, Vol 5, Iss 4, p 65 (2017)
Cryptococcus sp. are basidiomycete yeasts which can be found widely, free-living in the environment. Interactions with natural predators, such as amoebae in the soil, are thought to have promoted the development of adaptations enabling the organism t
Externí odkaz:
https://doaj.org/article/06e996893ad04fa09d65361c73cd4982
Autor:
Emad A. Rakha, David M. Heery, Cíntia J. Monteiro, Kartikeya Bhardwaj, Nigel P. Mongan, Wilbert Zwart, Mansour Alsaleem, Steffi Oesterreich, Takaaki Fujii, Ian O. Ellis, Andrew R. Green, Stacey E. P. Joosten, Sasagu Kurozumi, Ken Shirabe, Simon J Johnston
Publikováno v:
Cancer Research. 81:PS6-11
Invasive lobular carcinoma (ILC) accounts for 10-15% of primary breast cancer and is typically ER+ and ERBB2 non-amplified. There is preclinical evidence that somatic ERBB2 mutation may provide an alternative and tractable mechanism for upregulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2da10bff446abdd03d0a25ef03509681
https://doi.org/10.1158/1538-7445.sabcs20-ps6-11
https://doi.org/10.1158/1538-7445.sabcs20-ps6-11
Autor:
A. A. Roger Thompson, Laura West, Jaime Canedo, Amira Zawia, Adam Braithwaite, Allan Lawrie, Josephine A. Pickworth, Gaynor Miller, Nadine Arnold, Simon A. Johnston, Helena A Turton, James Iremonger
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology
Supplemental Digital Content is available in the text.
Objective: To determine whether global reduction of CD68 (cluster of differentiation) macrophages impacts the development of experimental pulmonary arterial hypertension (PAH) and whether th
Objective: To determine whether global reduction of CD68 (cluster of differentiation) macrophages impacts the development of experimental pulmonary arterial hypertension (PAH) and whether th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::396dcfa27043dc2e6637b549c8337e97
http://europepmc.org/articles/PMC7752239
http://europepmc.org/articles/PMC7752239
Autor:
Andrew R. Green, Ken Shirabe, Wilbert Zwart, Simon J Johnston, Steffi Oesterreich, David M. Heery, Sasagu Kurozumi, Emad A. Rakha, Ian O. Ellis, Takaaki Fujii
Publikováno v:
Cancer Research. 80:P1-18
Invasive lobular carcinoma accounts for 10-15% of breast cancer cases and typically expresses hormone receptors. Despite this, lobular tumours respond less well to endocrine therapy, and long-term patient outcomes are inferior to those with other bre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d9d94b577d1e82190c207b280ab5808
https://doi.org/10.1158/1538-7445.sabcs19-p1-18-06
https://doi.org/10.1158/1538-7445.sabcs19-p1-18-06
Publikováno v:
Oncology and Therapy, Vol 8, Iss 1, Pp 1-11 (2019)
Oncology and Therapy
Oncology and Therapy
Invasive lobular carcinoma comprises 10–15% of all breast cancers and is increasingly recognised as a distinct and understudied disease compared with the predominant histological subtype, invasive ductal carcinoma. Hallmarks of invasive lobular car
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb188ac412b509bf7d48f3f9c9d3bcbc
https://doaj.org/article/e810488bf9264f77af6e8949c4a287ac
https://doaj.org/article/e810488bf9264f77af6e8949c4a287ac