Výsledky vyhledávání - "Simon A. Hawley"

Akademický článek

Caspase cleavage and nuclear retention of the energy sensor AMPK-α1 during apoptosis

Autor: Anees Rahman Cheratta, Faisal Thayyullathil, Simon A. Hawley, Fiona A. Ross, Abdelmajdid Atrih, Douglas J. Lamont, Siraj Pallichankandy, Karthikeyan Subburayan, Ameer Alakkal, Rachid Rezgui, Alex Gray, D. Grahame Hardie, Sehamuddin Galadari

Publikováno v: Cell Reports, Vol 39, Iss 5, Pp 110761- (2022)

Summary: AMP-activated protein kinase (AMPK) coordinates energy homeostasis during metabolic and energy stress. We report that the catalytic subunit isoform AMPK-α1 (but not α2) is cleaved by caspase-3 at an early stage during induction of apoptosi

Externí odkaz: https://doaj.org/article/dc89a458593d474787f73e8f3cb61c58

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Aldolase is a sensor for both low and high glucose, linking to AMPK and mTORC1

Autor: Jin Wei Feng, Changchuan Xie, Hai-long Piao, Cixiong Zhang, Abdelmadjid Atrih, Xiao-Yan Wei, D. Grahame Hardie, Mengqi Li, Simon A. Hawley, Sheng-Cai Lin, Chen-Song Zhang, Zhichao Wang, Douglas J. Lamont, Yaying Wu

Publikováno v: Cell Research. 31:478-481

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc3144daa3665d424b7ff2f0bab6f78f
https://doi.org/10.1038/s41422-020-00456-8

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Mitochondria-localized AMPK responds to local energetics and contributes to exercise and energetic stress-induced mitophagy

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America

Significance Here, we present unequivocal evidence of physical association of AMPK holoenzymes with mitochondrial reticulum (mitoAMPK) across multiple mouse tissues with evidence of conservation in human skeletal muscle and heart. We demonstrate that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dacd6cacaed2ee2763e46a56be4eb882
https://hdl.handle.net/10919/107452

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Hierarchical activation of compartmentalized pools of AMPK depends on severity of nutrient or energy stress

Autor: Chen-Song Zhang, Simon A. Hawley, Yue Zong, Qu Qi, Jin-Wei Feng, D. Grahame Hardie, Sheng-Cai Lin, Zhichao Wang, Teng Ma, Mengqi Li, Yu-Qing Wu, Wen Wang, Cixiong Zhang, Hai-long Piao, Zhiyun Ye, Shu-Yong Lin, Xiao Tian

Publikováno v: Cell Research. 29:460-473

AMPK, a master regulator of metabolic homeostasis, is activated by both AMP-dependent and AMP-independent mechanisms. The conditions under which these different mechanisms operate, and their biological implications are unclear. Here, we show that, de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::824223d5ddb645484da8fce48dd62c7e
https://doi.org/10.1038/s41422-019-0163-6

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Mechanism of Activation of AMPK by Cordycepin

Autor: Simon A. Hawley, Abdelmadjid Atrih, Fiona M. Russell, D. Grahame Hardie, Douglas J. Lamont, Fiona A. Ross

Publikováno v: Cell Chemical Biology

Summary Cordycepin (3′-deoxyadenosine) is a major bioactive agent in Cordyceps militaris, a fungus used in traditional Chinese medicine. It has been proposed to have many beneficial metabolic effects by activating AMP-activated protein kinase (AMPK

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa3ea4a1ffa74332065e1943527bf8d0
https://pubmed.ncbi.nlm.nih.gov/31991096

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The Na+/Glucose Cotransporter Inhibitor Canagliflozin Activates AMPK by Inhibiting Mitochondrial Function and Increasing Cellular AMP Levels

Autor: Rebecca J. Ford, Brennan K. Smith, Ian P. Salt, Ryan D. Pitt, Graeme J. Gowans, Gregory R. Steinberg, Sarah J. Mancini, Emily A. Day, D. Grahame Hardie, Simon A. Hawley

Publikováno v: Diabetes. 65:2784-2794

Canagliflozin, dapagliflozin, and empagliflozin, all recently approved for treatment of type 2 diabetes, were derived from the natural product phlorizin. They reduce hyperglycemia by inhibiting glucose reuptake by sodium/glucose cotransporter (SGLT)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdb4a02c902e4f2b42acbbc5c3305421
https://doi.org/10.2337/db16-0058

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Cell-Free Assays to Measure Effects of Regulatory Ligands on AMPK

Autor: Fiona A, Fyffe, Simon A, Hawley, Alexander, Gray, D Grahame, Hardie

Publikováno v: Methods in molecular biology (Clifton, N.J.). 1732

AMP-activated protein kinase (AMPK) is an energy sensor that is activated by increases in the cellular AMP/ATP and ADP/ATP ratios by three mechanisms: (1) allosteric activation, (2) promotion of phosphorylation at Thr172 on the α subunit by upstream

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::eecbd05903d92938fe24330174f51539
https://pubmed.ncbi.nlm.nih.gov/29480469

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Intact Cell Assays to Monitor AMPK and Determine the Contribution of the AMP-Binding or ADaM Sites to Activation

Autor: Simon A, Hawley, Fiona A, Fyffe, Fiona M, Russell, Graeme J, Gowans, D, Grahame Hardie

Publikováno v: Methods in molecular biology (Clifton, N.J.). 1732

AMP-activated protein kinase (AMPK) is extremely sensitive to cellular stress, so that nonphysiological activation of the kinase can readily occur during harvesting of cells or tissues. In this chapter we describe methods to harvest cells and tissues

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7f4c3fdc805e24581aa766912ba0e3ff
https://pubmed.ncbi.nlm.nih.gov/29480480

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