Zobrazeno 1 - 10
of 122
pro vyhledávání: '"Simon A, Hirota"'
Autor:
Xiao Han, Joannie M. Allaire, Shauna M. Crowley, Jocelyn J. Chan, Kelly Lau, Conghao Zhang, Simon A. Hirota, Kirk Bergstrom, Leigh A. Knodler, Bruce A. Vallance
Publikováno v:
Gut Microbes, Vol 16, Iss 1 (2024)
The host restricts Salmonella enterica serovar Typhimurium infection of the gut via inflammasome-dependent sloughing of infected epithelial cells. Here we determined that concurrent caspase 1/11-dependent release of the goblet cell-derived mucin, Muc
Externí odkaz:
https://doaj.org/article/6c6253954466475d80d23564be718074
Autor:
Kyle L. Flannigan, Kristoff M. Nieves, Holly E. Szczepanski, Alex Serra, Joshua W. Lee, Laurie A. Alston, Hena Ramay, Sridhar Mani, Simon A. Hirota
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 15, Iss 3, Pp 765-795 (2023)
Background & Aims: Fibrosis is a common complication of inflammatory bowel diseases (IBDs). The pregnane X receptor (PXR) (encoded by NR1I2) suppresses intestinal inflammation and has been shown to influence liver fibrosis. In the intestine, PXR sign
Externí odkaz:
https://doaj.org/article/fe2e032f3ca34caba6075aaf93316e4c
Autor:
Nina L. Cluny, Kewir D. Nyuyki, Wagdi Almishri, Lateece Griffin, Benjamin H. Lee, Simon A. Hirota, Quentin J. Pittman, Mark G. Swain, Keith A. Sharkey
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-17 (2022)
Abstract Background Behavioral comorbidities, such as anxiety and depression, are a prominent feature of IBD. The signals from the inflamed gut that cause changes in the brain leading to these behavioral comorbidities remain to be fully elucidated. W
Externí odkaz:
https://doaj.org/article/ef43bce9d5ca482a970897fdee876d16
Autor:
Fernando A. Vicentini, Catherine M. Keenan, Laurie E. Wallace, Crystal Woods, Jean-Baptiste Cavin, Amanda R. Flockton, Wendy B. Macklin, Jaime Belkind-Gerson, Simon A. Hirota, Keith A. Sharkey
Publikováno v:
Microbiome, Vol 9, Iss 1, Pp 1-24 (2021)
Abstract Background The intestinal microbiota plays an important role in regulating gastrointestinal (GI) physiology in part through interactions with the enteric nervous system (ENS). Alterations in the gut microbiome frequently occur together with
Externí odkaz:
https://doaj.org/article/c218aabe31c34611bbed7773547b1901
Publikováno v:
Biofilm, Vol 4, Iss , Pp 100095- (2022)
Host immune cells and clinical interventions often fail to eradicate biofilm-mediated infections, resulting in chronic inflammation. The role of the biofilm three-dimensional structure in this tolerant phenotype has been studied extensively; however,
Externí odkaz:
https://doaj.org/article/6b7317cc872e47c394f12fb79ae0821b
Autor:
Zdeněk Dvořák, Felix Kopp, Cait M Costello, Jazmin S Kemp, Hao Li, Aneta Vrzalová, Martina Štěpánková, Iveta Bartoňková, Eva Jiskrová, Karolína Poulíková, Barbora Vyhlídalová, Lars U Nordstroem, Chamini V Karunaratne, Harmit S Ranhotra, Kyu Shik Mun, Anjaparavanda P Naren, Iain A Murray, Gary H Perdew, Julius Brtko, Lucia Toporova, Arne Schön, Bret D Wallace, William G Walton, Matthew R Redinbo, Katherine Sun, Amanda Beck, Sandhya Kortagere, Michelle C Neary, Aneesh Chandran, Saraswathi Vishveshwara, Maria M Cavalluzzi, Giovanni Lentini, Julia Yue Cui, Haiwei Gu, John C March, Shirshendu Chatterjee, Adam Matson, Dennis Wright, Kyle L Flannigan, Simon A Hirota, Ryan Balfour Sartor, Sridhar Mani
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 4, Pp 1-19 (2020)
Abstract The human PXR (pregnane X receptor), a master regulator of drug metabolism, has essential roles in intestinal homeostasis and abrogating inflammation. Existing PXR ligands have substantial off‐target toxicity. Based on prior work that esta
Externí odkaz:
https://doaj.org/article/3bc1d75f8f9149f2b831e9fe3ca8d3bb
Autor:
Nicolas Esquerre, Lilian Basso, Manon Defaye, Fernando A. Vicentini, Nina Cluny, Dominique Bihan, Simon A. Hirota, Alana Schick, Humberto B. Jijon, Ian A. Lewis, Markus B. Geuking, Keith A. Sharkey, Christophe Altier, Yasmin Nasser
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 2, Pp 225-244 (2020)
Background & Aims: Despite achieving endoscopic remission, more than 20% of inflammatory bowel disease patients experience chronic abdominal pain. These patients have increased rectal transient receptor potential vanilloid-1 receptor (TRPV1) expressi
Externí odkaz:
https://doaj.org/article/3b3125c1bc7c426db3bc2c65793c4a10
Autor:
Fernando A. Vicentini, Jake C. Szamosi, Laura Rossi, Lateece Griffin, Kristoff Nieves, Dominique Bihan, Ian A. Lewis, Quentin J. Pittman, Mark G. Swain, Michael G. Surette, Simon A. Hirota, Keith A. Sharkey
Publikováno v:
Brain, Behavior, and Immunity. 102:266-278
Inflammatory bowel diseases (IBD) are chronic inflammatory conditions of the gastrointestinal tract. IBD are associated with a high prevalence of cognitive, behavioural and emotional comorbidities, including anxiety and depression. The link between I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cefe906400c6564ac906509831077b0f
https://doi.org/10.1016/j.bbi.2022.03.001
https://doi.org/10.1016/j.bbi.2022.03.001
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 322:G268-G281
The commensal bacteria that reside in the gastrointestinal tract exist in a symbiotic relationship with the host, driving the development of the immune system and maintaining metabolic and tissue homeostasis in the local environment. The intestinal m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e2335c6377b3ac28b07fa126362f119
https://doi.org/10.1152/ajpgi.00160.2021
https://doi.org/10.1152/ajpgi.00160.2021
Autor:
Fernando A, Vicentini, Tanner, Fahlman, Stephanie G, Raptis, Laurie E, Wallace, Simon A, Hirota, Keith A, Sharkey
Publikováno v:
Advances in experimental medicine and biology. 1383
Propulsive gastrointestinal (GI) motility is critical for digestive physiology and host defense. GI motility is finely regulated by the intramural reflex pathways of the enteric nervous system (ENS). The ENS is in turn regulated by luminal factors: d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dea1861deac1f35a2b259dd871e784bd
https://pubmed.ncbi.nlm.nih.gov/36587146
https://pubmed.ncbi.nlm.nih.gov/36587146