Zobrazeno 1 - 10
of 286
pro vyhledávání: '"Simon M. Ametamey"'
Autor:
Sara L. Kroll, Lea M. Hulka, Ann-Kathrin Kexel, Matthias Vonmoos, Katrin H. Preller, Valerie Treyer, Simon M. Ametamey, Markus R. Baumgartner, Carola Boost, Franziska Pahlisch, Cathrin Rohleder, F. Markus Leweke, Boris B. Quednow
Publikováno v:
Translational Psychiatry, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Animal models indicate that the endocannabinoid system (ECS) plays a modulatory role in stress and reward processing, both crucially impaired in addictive disorders. Preclinical findings showed endocannabinoid-modulated synaptic plasticity i
Externí odkaz:
https://doaj.org/article/7a8d38696fea40e1b21459ae9a8de9ef
Autor:
Vasil Kecheliev, Francesco Spinelli, Adrienne Herde, Ahmed Haider, Linjing Mu, Jan Klohs, Simon M. Ametamey, Ruiqing Ni
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
Neuroinflammation plays an important role in the pathophysiology of Alzheimer’s disease. The cannabinoid type 2 receptor (CB2R) is an emerging target for neuroinflammation and therapeutics of Alzheimer’s disease. Here, we aim to assess the altera
Externí odkaz:
https://doaj.org/article/188f49f4cba045b28e831825027dbe1d
Autor:
Linjing Mu, Stefanie D. Kramer, Hazem Ahmed, Stefan Gruber, Susanne Geistlich, Roger Schibli, Simon M. Ametamey
Publikováno v:
CHIMIA, Vol 74, Iss 12, Pp 960-967 (2020)
Radiopharmacy at ETH has worked on the development of novel PET tracers for neuro-, cardiac- and tumor imaging for many years. In this paper, our efforts on targeting the glutamatergic system of the metabotropic glutamate receptor subtype 5 (mGluR5)
Externí odkaz:
https://doaj.org/article/71673d550f23497586a85da8a9df44b4
Autor:
Linjing Mu, Stefanie D. Krämer, Geoffrey I. Warnock, Ahmed Haider, Susan Bengs, Giovanni Cartolano, Dominic S. Bräm, Claudia Keller, Roger Schibli, Simon M. Ametamey, Philipp A. Kaufmann, Catherine Gebhard
Publikováno v:
EJNMMI Research, Vol 10, Iss 1, Pp 1-12 (2020)
Abstract Purpose Clinical positron emission tomography (PET) imaging of the presynaptic norepinephrine transporter (NET) function provides valuable diagnostic information on sympathetic outflow and neuronal status. As data on the NET-targeting PET tr
Externí odkaz:
https://doaj.org/article/a60c235670a0490c944eea8ec4994051
Autor:
Silvano Gnesin, Joachim Müller, Irene A. Burger, Alexander Meisel, Marco Siano, Martin Früh, Matthias Choschzick, Cristina Müller, Roger Schibli, Simon M. Ametamey, Philipp A. Kaufmann, Valerie Treyer, John O. Prior, Niklaus Schaefer
Publikováno v:
EJNMMI Research, Vol 10, Iss 1, Pp 1-12 (2020)
Abstract Background The folate receptor alpha (FRα) is an interesting target for imaging and therapy of different cancers. We present the first in-human radiation dosimetry and radiation safety results acquired within a prospective, multicentric tri
Externí odkaz:
https://doaj.org/article/938c265bac39444cb939078ace8779f5
Autor:
Bert-Ram Sah, Michael Sommerauer, Linjing Mu, Gloria Pla Gonzalez, Susanne Geistlich, Valerie Treyer, Roger Schibli, Alfred Buck, Geoffrey Warnock, Simon M. Ametamey
Publikováno v:
EJNMMI Research, Vol 9, Iss 1, Pp 1-6 (2019)
Abstract Purpose (E)-3-(pyridin-2-ylethynyl)cyclohex-2-enone O-(3-(2-[18F]-fluoroethoxy)propyl) oxime ([18F]-PSS232) is a new PET tracer for imaging of metabotropic glutamate receptor subtype 5 (mGlu5), and has shown promising results in rodents and
Externí odkaz:
https://doaj.org/article/25e65f188ff04962924eeba6d01738bc
Autor:
Hazem Ahmed, Livio Gisler, Nehal H. Elghazawy, Claudia Keller, Wolfgang Sippl, Steven H. Liang, Ahmed Haider, Simon M. Ametamey
Publikováno v:
Pharmaceuticals, Vol 15, Iss 8, p 960 (2022)
GluN2B-enriched N-methyl-D-aspartate receptors (NMDARs) are implicated in several neurodegenerative and psychiatric diseases, such as Alzheimer’s disease. No clinically valid GluN1/2B therapeutic exists due to a lack of selective GluN2B imaging too
Externí odkaz:
https://doaj.org/article/36a2d0dd3b5a4ce9855afe64542033d1
Autor:
Johannes Streffer, Valerie Treyer, Alfred Buck, Simon M. Ametamey, Milen Blagoev, Ralph P Maguire, Aurélie Gautier, Yves P. Auberson, Mark E. Schmidt, Ivan-Toma Vranesic, Baltazar Gomez-Mancilla, Fabrizio Gasparini
Publikováno v:
NeuroImage, Vol 230, Iss , Pp 117785- (2021)
Mavoglurant binds to same allosteric site on metabotropic glutamate receptor 5 (mGluR5) as [11C]-ABP688, a radioligand. This open-label, single-center pilot study estimates extent of occupancy of mGluR5 receptors following single oral doses of mavogl
Externí odkaz:
https://doaj.org/article/ade72d8efd5c49d88ff715c43ad5a8a3
Autor:
Valerie Treyer, Anton F. Gietl, Husam Suliman, Esmeralda Gruber, Rafael Meyer, Andreas Buchmann, Anass Johayem, Paul G. Unschuld, Roger M. Nitsch, Alfred Buck, Simon M. Ametamey, Christoph Hock
Publikováno v:
Brain and Behavior, Vol 10, Iss 6, Pp n/a-n/a (2020)
Abstract Introduction Metabotropic glutamate receptors play a critical role in the pathogenesis of Alzheimer's disease due to their involvement in processes of memory formation, neuroplasticity, and synaptotoxity. The objective of the current study w
Externí odkaz:
https://doaj.org/article/438971daf0114def963995fe9ad8c0ec
Publikováno v:
EJNMMI Radiopharmacy and Chemistry, Vol 3, Iss 1, Pp 1-11 (2018)
Abstract Background Analogues of exendin-4 have been radiolabeled for imaging the glucagon-like peptide type 1 receptors (GLP-1R) which are overexpressed in insulinoma. The aim of this research was to synthesize an 18F–labeled silicon containing ex
Externí odkaz:
https://doaj.org/article/5fc58739ae4f469d95f60d12a019d480