Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Simon Greenaway"'
Autor:
Helen S. Long, Simon Greenaway, George Powell, Ann-Marie Mallon, Cecilia M. Lindgren, Michelle M. Simon
Publikováno v:
Epigenetics & Chromatin, Vol 15, Iss 1, Pp 1-19 (2022)
Abstract Background Topologically associating domains (TADs) are thought to act as functional units in the genome. TADs co-localise genes and their regulatory elements as well as forming the unit of genome switching between active and inactive compar
Externí odkaz:
https://doaj.org/article/6f1e00ac446346aaa7cd852c08c47241
Autor:
Siddharth Sethi, Ilya E. Vorontsov, Ivan V. Kulakovskiy, Simon Greenaway, John Williams, Vsevolod J. Makeev, Steve D. M. Brown, Michelle M. Simon, Ann-Marie Mallon
Publikováno v:
BMC Genomics, Vol 21, Iss 1, Pp 1-22 (2020)
Abstract Background Efforts to elucidate the function of enhancers in vivo are underway but their vast numbers alongside differing enhancer architectures make it difficult to determine their impact on gene activity. By systematically annotating multi
Externí odkaz:
https://doaj.org/article/8f2ec8dcd8714977b405ae138aae5824
Autor:
Eva Lana-Elola, Heather Cater, Sheona Watson-Scales, Simon Greenaway, Jennifer Müller-Winkler, Dorota Gibbins, Mihaela Nemes, Amy Slender, Tertius Hough, Piia Keskivali-Bond, Cheryl L. Scudamore, Eleanor Herbert, Gareth T. Banks, Helene Mobbs, Tara Canonica, Justin Tosh, Suzanna Noy, Miriam Llorian, Patrick M. Nolan, Julian L. Griffin, Mark Good, Michelle Simon, Ann-Marie Mallon, Sara Wells, Elizabeth M. C. Fisher, Victor L. J. Tybulewicz
Publikováno v:
Disease Models & Mechanisms, Vol 14, Iss 10 (2021)
Down syndrome (DS), trisomy 21, results in many complex phenotypes including cognitive deficits, heart defects and craniofacial alterations. Phenotypes arise from an extra copy of human chromosome 21 (Hsa21) genes. However, these dosage-sensitive cau
Externí odkaz:
https://doaj.org/article/2e0de4e621364f88bbb0ae2f68e17fe9
Autor:
Michael R. Bowl, Michelle M. Simon, Neil J. Ingham, Simon Greenaway, Luis Santos, Heather Cater, Sarah Taylor, Jeremy Mason, Natalja Kurbatova, Selina Pearson, Lynette R. Bower, Dave A. Clary, Hamid Meziane, Patrick Reilly, Osamu Minowa, Lois Kelsey, The International Mouse Phenotyping Consortium, Glauco P. Tocchini-Valentini, Xiang Gao, Allan Bradley, William C. Skarnes, Mark Moore, Arthur L. Beaudet, Monica J. Justice, John Seavitt, Mary E. Dickinson, Wolfgang Wurst, Martin Hrabe de Angelis, Yann Herault, Shigeharu Wakana, Lauryl M. J. Nutter, Ann M. Flenniken, Colin McKerlie, Stephen A. Murray, Karen L. Svenson, Robert E. Braun, David B. West, K. C. Kent Lloyd, David J. Adams, Jacqui White, Natasha Karp, Paul Flicek, Damian Smedley, Terrence F. Meehan, Helen E. Parkinson, Lydia M. Teboul, Sara Wells, Karen P. Steel, Ann-Marie Mallon, Steve D. M. Brown
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
The full extent of the genetic basis for hearing impairment is unknown. Here, as part of the International Mouse Phenotyping Consortium, the authors perform a hearing loss screen in 3006 mouse knockout strains and identify 52 new candidate genes for
Externí odkaz:
https://doaj.org/article/c71478f2406844f6901b4df53eb1c02c
Autor:
Natasha A. Karp, Jeremy Mason, Arthur L. Beaudet, Yoav Benjamini, Lynette Bower, Robert E. Braun, Steve D.M. Brown, Elissa J. Chesler, Mary E. Dickinson, Ann M. Flenniken, Helmut Fuchs, Martin Hrabe de Angelis, Xiang Gao, Shiying Guo, Simon Greenaway, Ruth Heller, Yann Herault, Monica J. Justice, Natalja Kurbatova, Christopher J. Lelliott, K.C. Kent Lloyd, Ann-Marie Mallon, Judith E. Mank, Hiroshi Masuya, Colin McKerlie, Terrence F. Meehan, Richard F. Mott, Stephen A. Murray, Helen Parkinson, Ramiro Ramirez-Solis, Luis Santos, John R. Seavitt, Damian Smedley, Tania Sorg, Anneliese O. Speak, Karen P. Steel, Karen L. Svenson, International Mouse Phenotyping Consortium, Shigeharu Wakana, David West, Sara Wells, Henrik Westerberg, Shay Yaacoby, Jacqueline K. White
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Systemic dissection of sexually dimorphic phenotypes in mice is lacking. Here, Karp and the International Mouse Phenotype Consortium show that approximately 10% of qualitative traits and 56% of quantitative traits in mice as measured in laboratory se
Externí odkaz:
https://doaj.org/article/903b3cd9e9ab44c786e930b7a65ed71e
Autor:
Paul K. Potter, Michael R. Bowl, Prashanthini Jeyarajan, Laura Wisby, Andrew Blease, Michelle E. Goldsworthy, Michelle M. Simon, Simon Greenaway, Vincent Michel, Alun Barnard, Carlos Aguilar, Thomas Agnew, Gareth Banks, Andrew Blake, Lauren Chessum, Joanne Dorning, Sara Falcone, Laurence Goosey, Shelley Harris, Andy Haynes, Ines Heise, Rosie Hillier, Tertius Hough, Angela Hoslin, Marie Hutchison, Ruairidh King, Saumya Kumar, Heena V. Lad, Gemma Law, Robert E. MacLaren, Susan Morse, Thomas Nicol, Andrew Parker, Karen Pickford, Siddharth Sethi, Becky Starbuck, Femke Stelma, Michael Cheeseman, Sally H. Cross, Russell G. Foster, Ian J. Jackson, Stuart N. Peirson, Rajesh V. Thakker, Tonia Vincent, Cheryl Scudamore, Sara Wells, Aziz El-Amraoui, Christine Petit, Abraham Acevedo-Arozena, Patrick M. Nolan, Roger Cox, Anne-Marie Mallon, Steve D. M. Brown
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Random mutagenesis can uncover novel genes involved in phenotypic traits. Here the authors perform a large-scale phenotypic screen on over 100 mouse strains generated by ENU mutagenesis to identify mice with age-related diseases, which they attribute
Externí odkaz:
https://doaj.org/article/fa97ab87303c498f824c8286a0325379
Autor:
George Powell, Michelle Simon, Simon Greenaway, Ann-Marie Mallon, Helen S Long, Cecilia M. Lindgren
Publikováno v:
Epigenetics & Chromatin
Epigenetics & Chromatin, Vol 15, Iss 1, Pp 1-19 (2022)
Epigenetics & Chromatin, Vol 15, Iss 1, Pp 1-19 (2022)
Background Topologically associating domains (TADs) are thought to act as functional units in the genome. TADs co-localise genes and their regulatory elements as well as forming the unit of genome switching between active and inactive compartments. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c171245f0b87c9b315278eee73ad31e3
https://doi.org/10.1186/s13072-022-00436-9
https://doi.org/10.1186/s13072-022-00436-9
Autor:
Serge Nef, Violaine Regard, Pauline Sararols, Aitana Perea-Gomez, Andy Greenfield, Chloé Mayère, Cyril Djari, Isabelle Stévant, Dagmar Wilhelm, Diana Condrea, Michelle Simon, Richard Reeves, Corey Bunce, Françoise Kühne, Ivana Gantar, Marie-Christine Chaboissier, Laura Batti, Blanche Capel, Pam Siggers, Furong Tang, Simon Greenaway, Norbert B. Ghyselinck, Yasmine Neirijnck
Publikováno v:
Science Advances
Science Advances, American Association for the Advancement of Science (AAAS), 2022, 8 (21), ⟨10.1126/sciadv.abm0972⟩
Science Advances, American Association for the Advancement of Science (AAAS), 2022, 8 (21), ⟨10.1126/sciadv.abm0972⟩
Gonadal sex determination represents a unique model for studying cell fate decisions. However, a complete understanding of the different cell lineages forming the developing testis and ovary remains elusive. Here, we investigated the origin, specific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a6e15a3a3a4d77a50543cd79afaaad0
https://hal.archives-ouvertes.fr/hal-03370834/file/2021.09.15.460431v1.full.pdf
https://hal.archives-ouvertes.fr/hal-03370834/file/2021.09.15.460431v1.full.pdf
Autor:
Michelle Simon, Steve D.M. Brown, Ivan V. Kulakovskiy, Simon Greenaway, John A. Williams, Siddharth Sethi, Ann-Marie Mallon, Ilya E. Vorontsov, Vsevolod J. Makeev
Publikováno v:
BMC Genomics
BMC Genomics, Vol 21, Iss 1, Pp 1-22 (2020)
BMC Genomics, Vol 21, Iss 1, Pp 1-22 (2020)
Background Efforts to elucidate the function of enhancers in vivo are underway but their vast numbers alongside differing enhancer architectures make it difficult to determine their impact on gene activity. By systematically annotating multiple mouse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dbdb371b9567e66572716d39c81fd23
http://europepmc.org/articles/PMC7607678
http://europepmc.org/articles/PMC7607678
Publikováno v:
Current protocols in mouse biologyLiterature Cited. 10(3)
Over the last century, the study of mouse behavior has uncovered insights into brain molecular mechanisms while revealing potential causes of many neurological disorders. To this end, researchers have widely exploited the use of mutant strains, inclu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86e074f73b6085c8587d3fe2e1d585d4
https://pubmed.ncbi.nlm.nih.gov/32813317
https://pubmed.ncbi.nlm.nih.gov/32813317