Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Simon Cocklin"'
Autor:
Emily M. Esquea, Lorela Ciraku, Riley G. Young, Jessica Merzy, Alexandra N. Talarico, Nusaiba N. Ahmed, Mangalam Karuppiah, Anna Ramesh, Adam Chatoff, Claudia V. Crispim, Adel A. Rashad, Simon Cocklin, Nathaniel W. Snyder, Joris Beld, Nicole L. Simone, Mauricio J. Reginato, Alexej Dick
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Breast cancer brain metastasis (BCBM) typically results in an end-stage diagnosis and is hindered by a lack of brain-penetrant drugs. Tumors in the brain rely on the conversion of acetate to acetyl-CoA by the enzyme acetyl-CoA synthetase 2 (ACSS2), a
Externí odkaz:
https://doaj.org/article/4ae2b15c3c5446188251b5c916b863e7
Autor:
M. Frank Erasmus, Fortunato Ferrara, Sara D’Angelo, Laura Spector, Camila Leal-Lopes, André A. Teixeira, Jesper Sørensen, Suhani Nagpal, Kathryn Perea-Schmittle, Alok Choudhary, William Honnen, David Calianese, Luis Antonio Rodriguez Carnero, Simon Cocklin, Victor Greiff, Abraham Pinter, Andrew R. M. Bradbury
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract Therapeutic antibody discovery often relies on in-vitro display methods to identify lead candidates. Assessing selected output diversity traditionally involves random colony picking and Sanger sequencing, which has limitations. Next-generati
Externí odkaz:
https://doaj.org/article/9f677d7c2e9c4172a391dac8c4424094
Autor:
M. Frank Erasmus, Fortunato Ferrara, Sara D’Angelo, Laura Spector, Camila Leal-Lopes, André A. Teixeira, Jesper Sørensen, Suhani Nagpal, Kathryn Perea-Schmittle, Alok Choudhary, William Honnen, David Calianese, Luis Antonio Rodriguez Carnero, Simon Cocklin, Victor Greiff, Abraham Pinter, Andrew R. M. Bradbury
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-2 (2024)
Externí odkaz:
https://doaj.org/article/341f118a08db4ff7bb9c491729af0860
Autor:
M. Frank Erasmus, Fortunato Ferrara, Sara D’Angelo, Laura Spector, Camila Leal‑Lopes, André A. Teixeira, Jesper Sørensen, Suhani Nagpal, Kathryn Perea‑Schmittle, Alok Choudhary, William Honnen, David Calianese, Luis Antonio Rodriguez Carnero, Simon Cocklin, Victor Greiff, Abraham Pinter, Andrew R. M. Bradbury
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/857d7a448bd248a0ae37d45019f7079d
Autor:
Fortunato Ferrara, Sara D’Angelo, M. Frank Erasmus, André A. Teixeira, Camila Leal-Lopes, Laura P. Spector, Tom Pohl, Adeline Fanni, Simon Cocklin, Andrew R. M. Bradbury
Publikováno v:
mAbs, Vol 14, Iss 1 (2022)
The intense international focus on the COVID-19 pandemic has provided a unique opportunity to use a wide array of novel tools to carry out scientific studies on the SARS-CoV-2 virus. The value of these comparative studies extends far beyond their con
Externí odkaz:
https://doaj.org/article/ebe8d5a5441b46e99fcf4d950937542e
Autor:
John E. Chojnowski, Rongrong Li, Tiffany Tsang, Fatimah H. Alfaran, Alexej Dick, Simon Cocklin, Donita C. Brady, Todd I. Strochlic
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Casein kinase 2 (CK2) is an evolutionarily conserved serine/threonine kinase implicated in a wide range of cellular functions and known to be dysregulated in various diseases such as cancer. Compared to most other kinases, CK2 exhibits several unusua
Externí odkaz:
https://doaj.org/article/ccfe4ca0b5f74d71a73a5392371c6c1c
Autor:
Shujing Xu, Lin Sun, Waleed A. Zalloum, Tianguang Huang, Xujie Zhang, Dang Ding, Xiaoyu Shao, Xiangyi Jiang, Fabao Zhao, Simon Cocklin, Erik De Clercq, Christophe Pannecouque, Alexej Dick, Xinyong Liu, Peng Zhan
Publikováno v:
Molecules, Vol 27, Iss 23, p 8415 (2022)
HIV-1 capsid (CA) performs multiple roles in the viral life cycle and is a promising target for antiviral development. In this work, we describe the design, synthesis, assessment of antiviral activity, and mechanistic investigation of 20 piperazinone
Externí odkaz:
https://doaj.org/article/08d03fb8fcbd442c925e5a2912ff863d
Autor:
Xujie Zhang, Lin Sun, Shujing Xu, Xiaoyu Shao, Ziyi Li, Dang Ding, Xiangyi Jiang, Shujie Zhao, Simon Cocklin, Erik De Clercq, Christophe Pannecouque, Alexej Dick, Xinyong Liu, Peng Zhan
Publikováno v:
Molecules, Vol 27, Iss 21, p 7640 (2022)
The AIDS pandemic is still of importance. HIV-1 and HIV-2 are the causative agents of this pandemic, and in the absence of a viable vaccine, drugs are continually required to provide quality of life for infected patients. The HIV capsid (CA) protein
Externí odkaz:
https://doaj.org/article/4747e126c91b4eba9aaa4d43818f911e
Autor:
Xiangkai Ji, Jing Li, Prem Prakash Sharma, Xiangyi Jiang, Brijesh Rathi, Zhen Gao, Lide Hu, Dongwei Kang, Erik De Clercq, Simon Cocklin, Chuanfeng Liu, Christophe Pannecouque, Alexej Dick, Xinyong Liu, Peng Zhan
Publikováno v:
Molecules, Vol 27, Iss 18, p 5995 (2022)
As a key structural protein, HIV capsid (CA) protein plays multiple roles in the HIV life cycle, and is considered a promising target for anti-HIV treatment. Based on the structural information of CA modulator PF-74 bound to HIV-1 CA hexamer, 18 nove
Externí odkaz:
https://doaj.org/article/97f7765db41045cbadc4b893f8b9bc68
Autor:
Angel Lin, Weam Othman Elbezanti, Alexis Schirling, Adel Ahmed, Rachel Van Duyne, Simon Cocklin, Zachary Klase
Publikováno v:
Frontiers in Neurology, Vol 12 (2021)
The HIV-1 pandemic is a significant challenge to the field of medicine. Despite advancements in antiretroviral (ART) development, 38 million people worldwide still live with this disease without a cure. A significant barrier to the eradication of HIV
Externí odkaz:
https://doaj.org/article/407f56e130394e5f93ffbeac3e52c868