Zobrazeno 1 - 10
of 223
pro vyhledávání: '"Simon J. Cook"'
Autor:
Joanne L. Wood, Stephan Harrison, Ryan Wilson, Adam Emmer, Jeffrey S. Kargel, Simon J. Cook, Neil F. Glasser, John M. Reynolds, Dan H. Shugar, Christian Yarleque
Publikováno v:
Geophysical Research Letters, Vol 51, Iss 7, Pp n/a-n/a (2024)
Abstract As the world’s glaciers recede in response to a warming atmosphere, a change in the magnitude and frequency of related hazards is expected. Among the most destructive hazards are glacier lake outburst floods (GLOFs), and their future evolu
Externí odkaz:
https://doaj.org/article/5c291689651b42169daf04d9ba245f55
Publikováno v:
Journal of Water and Climate Change, Vol 13, Iss 2, Pp 482-504 (2022)
Climate change has implications for water resources by increasing temperature, shifting precipitation patterns and altering the timing of snowfall and glacier melt, leading to shifts in the seasonality of river flows. Here, the Soil & Water Assessmen
Externí odkaz:
https://doaj.org/article/65bb7f83a48040798528d575d0cdeadc
Autor:
Ethan Lee, Jonathan L. Carrivick, Duncan J. Quincey, Simon J. Cook, William H. M. James, Lee E. Brown
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
Abstract Himalayan glaciers are undergoing rapid mass loss but rates of contemporary change lack long-term (centennial-scale) context. Here, we reconstruct the extent and surfaces of 14,798 Himalayan glaciers during the Little Ice Age (LIA), 400 to 7
Externí odkaz:
https://doaj.org/article/98c051c1609d4adfa1dd2fdb4bd6f827
Autor:
Simon J. Cook, Pamela A. Lochhead
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
The RAS-regulated RAF-MEK1/2-ERK1/2 signalling pathway is frequently de-regulated in human cancer. Melanoma in particular exhibits a high incidence of activating BRAFV600E/K and NRASQ61L/K mutations and such cells are addicted to the activity of thes
Externí odkaz:
https://doaj.org/article/3a13eac860ed4e48b91f9389ed52f702
Autor:
Pamela A. Lochhead, Julie A. Tucker, Natalie J. Tatum, Jinhua Wang, David Oxley, Andrew M. Kidger, Victoria P. Johnson, Megan A. Cassidy, Nathanael S. Gray, Martin E. M. Noble, Simon J. Cook
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Selective ERK5 inhibitors target ERK5 kinase activity, but they do not phenocopy the effects of ERK5 genetic depletion. Here, the authors demonstrate that the direct interaction of these inhibitors to ERK5 kinase domain induces conformational changes
Externí odkaz:
https://doaj.org/article/74f91df61c624308a4815d6adcffb1f9
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-7 (2020)
Glaciers have profoundly shaped Earth’s surface, but glacial erosion models lack a strong empirical basis. Cook et al. have compiled a dataset that illustrates how the speed at which glaciers move controls the rate at which they erode, and that cli
Externí odkaz:
https://doaj.org/article/a1bbf075bdf44c958059723da497d237
Publikováno v:
PLoS ONE, Vol 17, Iss 8, p e0271991 (2022)
Climate change plays a key role in changing vegetation productivity dynamics, which ultimately affect the hydrological cycle of a watershed through evapotranspiration (ET). Trends and correlation analysis were conducted to investigate vegetation resp
Externí odkaz:
https://doaj.org/article/33433db7f88447b588b3d4386ed924db
Publikováno v:
Frontiers in Earth Science, Vol 9 (2021)
Externí odkaz:
https://doaj.org/article/8762d90015884d61bf7bc5852e4381ef
Autor:
Simon J. Cook
This book provides a contextual study of the development of Alfred Marshall's thinking during the early years of his apprenticeship in the Cambridge moral sciences. Marshall's thought is situated in a crisis of academic liberal thinking that occurred
Autor:
Matthew J. Sale, Emma Minihane, Noel R. Monks, Rebecca Gilley, Frances M. Richards, Kevin P. Schifferli, Courtney L. Andersen, Emma J. Davies, Mario Aladren Vicente, Eiko Ozono, Aleksandra Markovets, Jonathan R. Dry, Lisa Drew, Vikki Flemington, Theresa Proia, Duncan I. Jodrell, Paul D. Smith, Simon J. Cook
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
BRAF or MEK1/2 inhibitors are cytostatic in melanoma and the surviving cells develop drug resistance. This study shows that the pro-survival pool is biased towards MCL1 in melanoma so that BRAF or MEK1/2 inhibitors are synthetic lethal with the MCL1
Externí odkaz:
https://doaj.org/article/03dfbb8e162440b8bfec0b14545e606c