Zobrazeno 1 - 10
of 208
pro vyhledávání: '"Simon, Phipps"'
Autor:
Bodie Curren, Tufael Ahmed, Ridwan B. Rashid, Ismail Sebina, Md. Al Amin Sikder, Daniel R. Howard, Mariah Alorro, Md. Ashik Ullah, Alec Bissell, Muhammed Mahfuzur Rahman, Michael A. Pearen, Grant A. Ramm, Antiopi Varelias, Stefan Rose-John, Kelli P.A. MacDonald, Robert Hoelzle, Páraic Ó Cuív, Kirsten M. Spann, Paul G. Dennis, Simon Phipps
Publikováno v:
Cell Reports, Vol 43, Iss 11, Pp 114974- (2024)
Summary: A poor maternal diet during pregnancy predisposes the infant to severe lower respiratory tract infections (sLRIs), which, in turn, increases childhood asthma risk; however, the underlying mechanisms remain poorly understood. Here, we show th
Externí odkaz:
https://doaj.org/article/35ed73a82c044bd8a5ad26ee440d31fb
Autor:
Pramila Maniam, Ama-Tawiah Essilfie, Murugan Kalimutho, Dora Ling, David M. Frazer, Simon Phipps, Gregory J. Anderson, David W. Reid
Publikováno v:
Biological Research, Vol 54, Iss 1, Pp 1-13 (2021)
Abstract Background Defective chloride transport in airway epithelial cells (AECs) and the associated lung disease are the main causes of morbidity and early mortality in cystic fibrosis (CF). Abnormal airway iron homeostasis and the presence of lipi
Externí odkaz:
https://doaj.org/article/bb6dd0f664b5421b87098d1ad69a917b
Autor:
Wen Juan Tu, Robert D. McCuaig, Michelle Melino, Daniel J. Rawle, Thuy T. Le, Kexin Yan, Andreas Suhrbier, Rebecca L. Johnston, Lambros T. Koufariotis, Nicola Waddell, Emily M. Cross, Sofiya Tsimbalyuk, Amanda Bain, Elizabeth Ahern, Natasha Collinson, Simon Phipps, Jade K. Forwood, Nabila Seddiki, Sudha Rao
Publikováno v:
Cell Discovery, Vol 7, Iss 1, Pp 1-25 (2021)
Abstract Treatment options for COVID-19 remain limited, especially during the early or asymptomatic phase. Here, we report a novel SARS-CoV-2 viral replication mechanism mediated by interactions between ACE2 and the epigenetic eraser enzyme LSD1, and
Externí odkaz:
https://doaj.org/article/94d2222dd5d142eaabe147edc4a852eb
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Respiratory syncytial virus (RSV)-induced bronchiolitis is a significant contributor to infant morbidity and mortality. Previously, we identified that necroptosis, a pro-inflammatory form of cell death mediated by receptor-interacting serine/threonin
Externí odkaz:
https://doaj.org/article/3561f2d5787a4944bc3121e0ac7d2e56
Autor:
Sam Manna, Julie McAuley, Jonathan Jacobson, Cattram D. Nguyen, Md. Ashik Ullah, Ismail Sebina, Victoria Williamson, E. Kim Mulholland, Odilia Wijburg, Simon Phipps, Catherine Satzke
Publikováno v:
mSphere, Vol 7, Iss 1 (2022)
ABSTRACT Streptococcus pneumoniae (the pneumococcus) is a leading cause of pneumonia in children under 5 years of age. Coinfection by pneumococci and respiratory viruses enhances disease severity. Little is known about pneumococcal coinfections with
Externí odkaz:
https://doaj.org/article/84f46a9e41554702bd5f8ef3bea73ca5
Autor:
Stuart B. Mazzone, Seung-Kwon Yang, Jennifer A. Keller, Juste Simanauskaite, Jaisy Arikkatt, Matthew J. Fogarty, Aung Aung Kywe Moe, Chen Chen, Matthew W. Trewella, Luyi Tian, Matthew E. Ritchie, Brendan Y. Chua, Simon Phipps, Kirsty R. Short, Alice E. McGovern
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Vagal sensory neurons contribute to the symptoms and pathogenesis of inflammatory pulmonary diseases through processes that involve changes to their morphological and functional characteristics. The alarmin high mobility group box-1 (HMGB1) is an ear
Externí odkaz:
https://doaj.org/article/290a350339b04b75b5ded892b012d568
Autor:
Jemma Nicholls, Benjamin Cao, Laetitia Le Texier, Laura Yan Xiong, Christopher R. Hunter, Genesis Llanes, Ethan G. Aguliar, Wayne A. Schroder, Simon Phipps, Jason P. Lynch, Huimin Cao, Shen Y. Heazlewood, Brenda Williams, Andrew D. Clouston, Christian M. Nefzger, Jose M. Polo, Susan K. Nilsson, Bruce R. Blazar, Kelli P. A. MacDonald
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Regulatory T cell (Treg) reconstitution is essential for reestablishing tolerance and maintaining homeostasis following stem-cell transplantation. We previously reported that bone marrow (BM) is highly enriched in autophagy-dependent Treg and autopha
Externí odkaz:
https://doaj.org/article/27d02299a5ee475cab524537e8e3a0b4
Autor:
Katina D Hulme, Anjana C Karawita, Cassandra Pegg, Myrna JM Bunte, Helle Bielefeldt-Ohmann, Conor J Bloxham, Silvie Van den Hoecke, Yin Xiang Setoh, Bram Vrancken, Monique Spronken, Lauren E Steele, Nathalie AJ Verzele, Kyle R Upton, Alexander A Khromykh, Keng Yih Chew, Maria Sukkar, Simon Phipps, Kirsty R Short
Publikováno v:
eLife, Vol 10 (2021)
Influenza virus has a high mutation rate, such that within one host different viral variants can emerge. Evidence suggests that influenza virus variants are more prevalent in pregnant and/or obese individuals due to their impaired interferon response
Externí odkaz:
https://doaj.org/article/bf6df5e1336e47158a87381401c4414d
Autor:
Wen Juan Tu, Robert D. McCuaig, Michelle Melino, Daniel J. Rawle, Thuy T. Le, Kexin Yan, Andreas Suhrbier, Rebecca L. Johnston, Lambros T. Koufariotis, Nicola Waddell, Emily M. Cross, Sofiya Tsimbalyuk, Amanda Bain, Elizabeth Ahern, Natasha Collinson, Simon Phipps, Jade K. Forwood, Nabila Seddiki, Sudha Rao
Publikováno v:
Cell Discovery, Vol 7, Iss 1, Pp 1-2 (2021)
Externí odkaz:
https://doaj.org/article/5015f4b9a04d4d998c8e67847e08b80b
Autor:
Zhixuan Loh, Jennifer Simpson, Ashik Ullah, Vivian Zhang, Wan J Gan, Jason P Lynch, Rhiannon B Werder, Al Amin Sikder, Katie Lane, Choon Boon Sim, Enzo Porrello, Stuart B Mazzone, Peter D Sly, Raymond J Steptoe, Kirsten M Spann, Maria B Sukkar, John W Upham, Simon Phipps
Publikováno v:
PLoS Pathogens, Vol 16, Iss 7, p e1008651 (2020)
Type-2 immunity elicits tissue repair and homeostasis, however dysregulated type-2 responses cause aberrant tissue remodelling, as observed in asthma. Severe respiratory viral infections in infancy predispose to later asthma, however, the processes t
Externí odkaz:
https://doaj.org/article/707c4afdce5f46bf961c94b17ce97840