Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Simon, Messner"'
Autor:
Todd Carmody, Rebekah Park, Elisabeth Bennett, Emily Kuret, Beyza Klein, Àngels Costa, Simon Messner, Amelia Hursey
Publikováno v:
Neurology and Therapy, Vol 13, Iss 4, Pp 1219-1235 (2024)
Abstract Introduction Existing qualitative research on early-stage Parkinson’s disease draws on patients’ reported disease experience, aiming to capture the symptoms and impacts most relevant to patients living with the disease. As a complement t
Externí odkaz:
https://doaj.org/article/5dba6d14a6984b5e81ebdb72825ac380
Autor:
Michael O. Hottiger, Max Gassmann, Stephan Keller, Taras Valovka, Simon Messner, Suheda Erener, Paul O. Hassa, Lubor Borsig, Michael Elser
Hypoxia-inducible factor 1 (HIF-1) is the key transcription factor regulating hypoxia-dependent gene expression. Lack of oxygen stabilizes HIF-1, which in turn modulates the gene expression pattern to adapt cells to the hypoxic environment. Activatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ec2b7ad7081efb235317ab87839a86c
https://doi.org/10.1158/1541-7786.c.6542742
https://doi.org/10.1158/1541-7786.c.6542742
Autor:
Michael O. Hottiger, Max Gassmann, Stephan Keller, Taras Valovka, Simon Messner, Suheda Erener, Paul O. Hassa, Lubor Borsig, Michael Elser
Supplementary Figure S1 from Poly(ADP-Ribose) Polymerase 1 Promotes Tumor Cell Survival by Coactivating Hypoxia-Inducible Factor-1–Dependent Gene Expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04d5dbcc2f624ebfa4073369a29c0672
https://doi.org/10.1158/1541-7786.22520718
https://doi.org/10.1158/1541-7786.22520718
Autor:
Himanish Ghosh, Luca Auguadri, Sereina Battaglia, Zahra Simone Thirouin, Khaled Zemoura, Simon Messner, Mario A. Acuña, Hendrik Wildner, Gonzalo E. Yévenes, Andrea Dieter, Hiroshi Kawasaki, Michael O. Hottiger, Hanns Ulrich Zeilhofer, Jean-Marc Fritschy, Shiva K. Tyagarajan
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
Gephyrin is a cytoplasmic scaffolding protein that selectively forms postsynaptic scaffolds at GABAergic and glycinergic synapses. Here the authors characterize regulatory mechanisms determining gephyrin scaffolding and GABAA receptor synaptic transm
Externí odkaz:
https://doaj.org/article/73ddc1c5e39d47848b61414b2085adaa
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0179995 (2017)
Currently most liver fibrosis research is performed in vivo, since suitable alternative in vitro systems which are able to recapitulate the cellular events leading to liver fibrosis are lacking. Here we aimed at generating a system containing cells r
Externí odkaz:
https://doaj.org/article/e749945b756e441dbf456b3056909393
Autor:
Mathias Wind, Paul B. Watkins, Martina Maurer, Marc Engelhardt, Simon Messner, Anne Schmitt-Hoffmann, Jochen Spickermann, Franziska Paech, Jeffrey L. Woodhead, Anne-Therese Witschi, Brett A. Howell, Scott Q. Siler, Stephan Krähenbühl
Publikováno v:
Clinical and Translational Science. 11:498-505
Elevations of liver enzymes have been observed in clinical trials with BAL30072, a novel antibiotic. In vitro assays have identified potential mechanisms for the observed hepatotoxicity, including electron transport chain (ETC) inhibition and reactiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2fca62afdc992a3b97a30d486c944b62
https://doi.org/10.1111/cts.12560
https://doi.org/10.1111/cts.12560
Autor:
Lisa Fredriksson, Claudia Escher, Katrin Roessger, Magdalena Bober, Simon Messner, Volker M. Lauschke, Magnus Ingelman-Sundberg, Wolfgang Moritz, Jens M. Kelm
Publikováno v:
Applied in Vitro Toxicology
Three-Dimensional (3D) liver microtissues, specifically prepared from primary human hepatocytes (PHH) in coculture with nonparenchymal cells (NPCs), have been shown to be a valuable tool for in vitro toxicology. However, a lack of thorough characteri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7625bd5c5d9679b345964f1487434e92
https://doi.org/10.1089/aivt.2017.0022
https://doi.org/10.1089/aivt.2017.0022
Autor:
Martina Maurer, Marc Engelhardt, Jeff Woodhead, Simon Messner, Stephan Krähenbühl, Franziska Paech, Brett A. Howell, Jochen Spickermann, Rachel J. Church, Anne-Hortense Schmitt-Hoffmann, Mathias Wind, Anne Therese Witschi
Publikováno v:
Archives of Toxicology. 91:3647-3662
BAL30072 is a new monocyclic β-lactam antibiotic under development which provides a therapeutic option for the treatment of severe infections caused by multi-drug-resistant Gram-negative bacteria. Despite the absence of liver toxicity in preclinical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3be1d98e883d77bf868cbde0f34a3250
https://doi.org/10.1007/s00204-017-1994-x
https://doi.org/10.1007/s00204-017-1994-x
Autor:
Jeffrey L, Woodhead, Franziska, Paech, Martina, Maurer, Marc, Engelhardt, Anne H, Schmitt-Hoffmann, Jochen, Spickermann, Simon, Messner, Mathias, Wind, Anne-Therese, Witschi, Stephan, Krähenbühl, Scott Q, Siler, Paul B, Watkins, Brett A, Howell
Publikováno v:
Clinical and Translational Science
Elevations of liver enzymes have been observed in clinical trials with BAL30072, a novel antibiotic. In vitro assays have identified potential mechanisms for the observed hepatotoxicity, including electron transport chain (ETC) inhibition and reactiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8ea01777609800b325bb4d15f93d075d
https://pubmed.ncbi.nlm.nih.gov/29877622
https://pubmed.ncbi.nlm.nih.gov/29877622
Autor:
Tobias Ehrenberger, Saša M. Miladinović, Oliver M. Bernhardt, Olga Vitek, Lin-Yang Cheng, Tejas Gandhi, Roland Bruderer, Simon Messner, Vito R T Zanotelli, Lukas Reiter, Claudia Escher, Oliver Rinner, Yulia Butscheid
Publikováno v:
Molecular & Cellular Proteomics : MCP
Molecular & Cellular Proteomics, 14 (5)
Molecular & Cellular Proteomics, 14 (5)
The data-independent acquisition (DIA) approach has recently been introduced as a novel mass spectrometric method that promises to combine the high content aspect of shotgun proteomics with the reproducibility and precision of selected reaction monit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c99ee82cdf6d2b9c0d9f1582cddcf12
http://europepmc.org/articles/PMC4424408
http://europepmc.org/articles/PMC4424408