Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Simon, Lambden"'
Autor:
Simon Lambden, Andrew S. Cowburn, David Macias, Tessa A. C. Garrud, Bernardo J. Krause, Dino A. Giussani, Charlotte Summers, Randall S. Johnson
Publikováno v:
Intensive Care Medicine Experimental, Vol 9, Iss 1, Pp 1-14 (2021)
Abstract Background The vascular endothelium has important endocrine and paracrine roles, particularly in the regulation of vascular tone and immune function, and it has been implicated in the pathophysiology of a range of cardiovascular and inflamma
Externí odkaz:
https://doaj.org/article/cf0bda5a0deb42bf96cc27c38c5aa663
Autor:
Simon Lambden
Publikováno v:
Intensive Care Medicine Experimental, Vol 7, Iss 1, Pp 1-14 (2019)
Abstract Nitric oxide is a signalling molecule with an extensive range of functions in both health and disease. Discovered in the 1980s through work that earned the Nobel prize, nitric oxide is an essential factor in regulating cardiovascular, immune
Externí odkaz:
https://doaj.org/article/fc2d449bb2744876a19a87cd7685ff93
Autor:
Pierre-François Laterre, Stephan Witte, Jean-Marie Grouin, Simon Lambden, Bruno Francois, Sebastien Gibot, Marc Derive, Aurelie Olivier, Valerie Cuvier, Jean Jacques Garaud, Margarita Salcedo-Magguilli, Mitchell Levy
Publikováno v:
BMJ Open, Vol 11, Iss 7 (2021)
Introduction Septic shock is the subgroup of patients with sepsis, which presents as vasopressor dependence, an elevated blood lactate concentration and is associated with a mortality of at least 30%. Expression of the triggering receptor expressed o
Externí odkaz:
https://doaj.org/article/9b17e8be3e3443cebf020fb85a967645
Publikováno v:
Critical Care, Vol 23, Iss 1, Pp 1-9 (2019)
Abstract The Sequential Organ Failure Assessment or SOFA score was developed to assess the acute morbidity of critical illness at a population level and has been widely validated as a tool for this purpose across a range of healthcare settings and en
Externí odkaz:
https://doaj.org/article/a43fb45ba0c740ee8815722b64b99229
Autor:
Ana Gutierrez del Arroyo, Anna Hadjihambi, Jenifer Sanchez, Egor Turovsky, Vitaly Kasymov, David Cain, Tom D. Nightingale, Simon Lambden, Seth G.N. Grant, Alexander V. Gourine, Gareth L. Ackland
Publikováno v:
EBioMedicine, Vol 47, Iss , Pp 457-469 (2019)
Background: Neutrophil depletion improves neurologic outcomes in experimental sepsis/brain injury. We hypothesized that neutrophils may exacerbate neuronal injury through the release of neurotoxic quantities of the neurotransmitter glutamate. Methods
Externí odkaz:
https://doaj.org/article/0aaa2e17d6344966b236b4d45e768b8f
Publikováno v:
Critical Care, Vol 22, Iss 1, Pp 1-9 (2018)
Abstract Background Dimethylarginine dimethylaminohydrolase 2 (DDAH2) regulates the synthesis of nitric oxide (NO) through the metabolism of the endogenous inhibitor of nitric oxide synthase, asymmetric dimethylarginine (ADMA). Pilot studies have ass
Externí odkaz:
https://doaj.org/article/9eac1eb0716e49839eb64586d7bbcb09
Autor:
Susan F. Fitzpatrick, Simon Lambden, David Macias, Zudin Puthucheary, Sandra Pietsch, Lee Mendil, Mark J. W. McPhail, Randall S. Johnson
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
The metabolic response to endotoxemia closely mimics those seen in sepsis. Here, we show that the urinary excretion of the metabolite 2-hydroxyglutarate (2HG) is dramatically suppressed following lipopolysaccharide (LPS) administration in vivo, and i
Externí odkaz:
https://doaj.org/article/00435b3729d84c3e808bfa4ffbe064d9
Publikováno v:
Critical Care, Vol 22, Iss 1, Pp 1-8 (2018)
Abstract Vasoplegia is the syndrome of pathological low systemic vascular resistance, the dominant clinical feature of which is reduced blood pressure in the presence of a normal or raised cardiac output. The vasoplegic syndrome is encountered in man
Externí odkaz:
https://doaj.org/article/c5548e82d55047dc91a11c10fac0dd7f
Autor:
Bruno François, Simon Lambden, Tom Fivez, Sebastien Gibot, Marc Derive, Jean-Marie Grouin, Margarita Salcedo-Magguilli, Jérémie Lemarié, Nicolas De Schryver, Ville Jalkanen, Tarik Hicheur, Jean-Jacques Garaud, Valérie Cuvier, Ricard Ferrer, Morten Bestle, Ville Pettilä, Jean-Paul Mira, Camille Bouisse, Emmanuelle Mercier, Joris Vermassen, Vincent Huberlant, Isabelle Vinatier, Nadia Anguel, Mitchell Levy, Pierre-François Laterre, Pierre Asfar, Mai-Anh Nay, Christophe Guitton, Jean-Pierre Quenot, David Tran-Van, Julien Bohe, Gaëtan Plantefève, Saadalla Nseir, Jean-Yves Lefrant, Xavier Monnet, Laurent Papazian, Christophe Vinsonneau, Jean-Michel Constantin, Alexandre Mebazaa, Haikel Oueslati, Dolores Escudero, Fernando Martinez Sagasti, Enrique Piacentini, Paula Ramirez Galleymore, Thierry Dugernier, David Fagnoul, Isabelle Michaux, Allan Seibert, Matti Reinikainen, Thorbjørn Grøfte, Ignacio Martin-Loeches, John Laffey
Publikováno v:
The Lancet Respiratory Medicine.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::138a93f456f842d5fea1fe47b5e1674b
https://doi.org/10.1016/s2213-2600(23)00158-3
https://doi.org/10.1016/s2213-2600(23)00158-3
Autor:
Bruno François, Simon Lambden, Jean-Jacques Garaud, Marc Derive, Jean-Marie Grouin, Pierre Asfar, Cédric Darreau, Jean-Paul Mira, Jean-Pierre Quenot, Jérémie Lemarié, Emmanuelle Mercier, Jean-Claude Lacherade, Christophe Vinsonneau, Tom Fivez, Julie Helms, Julio Badie, Mitchell Levy, Valérie Cuvier, Margarita Salcedo-Magguilli, Anne-Lise Laszlo-Pouvreau, Pierre-François Laterre, Sébastien Gibot
Publikováno v:
eClinicalMedicine. :102013
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3d1a0dc66e1ff2af8e9e6a9cb3a108f
https://doi.org/10.1016/j.eclinm.2023.102013
https://doi.org/10.1016/j.eclinm.2023.102013