Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Simon, Heilbronner"'
Autor:
Ralf Rosenstein, Benjamin O. Torres Salazar, Claudia Sauer, Simon Heilbronner, Bernhard Krismer, Andreas Peschel
Publikováno v:
Microbiome, Vol 12, Iss 1, Pp 1-17 (2024)
Abstract Background Bacterial pathogens such as Staphylococcus aureus colonize body surfaces of part of the human population, which represents a critical risk factor for skin disorders and invasive infections. However, such pathogens do not belong to
Externí odkaz:
https://doaj.org/article/3a28cda8a55a45cea656f1ca269c2d37
Autor:
Stephen R. Garrett, Nicole Mietrach, Justin Deme, Alina Bitzer, Yaping Yang, Fatima R. Ulhuq, Dorothee Kretschmer, Simon Heilbronner, Terry K. Smith, Susan M. Lea, Tracy Palmer
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract The type VII protein secretion system (T7SS) is found in many Gram-positive bacteria and in pathogenic mycobacteria. All T7SS substrate proteins described to date share a common helical domain architecture at the N-terminus that typically in
Externí odkaz:
https://doaj.org/article/614445c295ff47b0b6acfe1519669f17
Autor:
Rui Zhao, Bingyu Du, Yue Luo, Fen Xue, Huanhuan Wang, Di Qu, Shiqing Han, Simon Heilbronner, Yanfeng Zhao
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 3 (2024)
ABSTRACTStaphylococcus aureus (S. aureus) causes many infections with significant morbidity and mortality. S. aureus can form biofilms, which can cause biofilm-associated diseases and increase resistance to many conventional antibiotics, resulting in
Externí odkaz:
https://doaj.org/article/1c3e265a84e64d0eac76afc82f2cc3aa
Publikováno v:
Frontiers in Bioinformatics, Vol 3 (2023)
Introduction: Genome-scale metabolic models (GEMs) are organism-specific knowledge bases which can be used to unravel pathogenicity or improve production of specific metabolites in biotechnology applications. However, the validity of predictions for
Externí odkaz:
https://doaj.org/article/808689ee433e4453ad44e56a296d1eba
Autor:
Lea Antje Adolf, Angelika Müller-Jochim, Lara Kricks, Jan-Samuel Puls, Daniel Lopez, Fabian Grein, Simon Heilbronner
Publikováno v:
eLife, Vol 12 (2023)
Sufficient access to transition metals such as iron is essential for bacterial proliferation and their active limitation within host tissues effectively restricts infection. To overcome iron limitation, the invasive pathogen Staphylococcus aureus use
Externí odkaz:
https://doaj.org/article/ccf7a63fc78b427b847420d8462a612f
Autor:
Sophia Krauss, Theresa A. Harbig, Johanna Rapp, Timm Schaefle, Mirita Franz-Wachtel, Leonie Reetz, Ahmed M. A. Elsherbini, Boris Macek, Stephanie Grond, Hannes Link, Kay Nieselt, Bernhard Krismer, Andreas Peschel, Simon Heilbronner
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 1 (2023)
ABSTRACT Biosynthetic gene clusters (BGCs) encoding the production of bacteriocins are widespread among bacterial isolates and are important genetic determinants of competitive fitness within a given habitat. Staphylococci produce a tremendous divers
Externí odkaz:
https://doaj.org/article/fb2900638a02438e90f389423ed3b167
Autor:
Anna Walzl, Helene Marbach, Darya Belikova, Claus Vogl, Monika Ehling-Schulz, Simon Heilbronner, Tom Grunert
Publikováno v:
Antibiotics, Vol 12, Iss 4, p 699 (2023)
Phenotypic adaptation has been associated with persistent, therapy-resistant Staphylococcus aureus infections. Recently, we described within-host evolution towards a Sigma factor B (SigB)-deficient phenotype in a non-human host, a naturally infected
Externí odkaz:
https://doaj.org/article/d4ff645a031642868ab0cc35098c834e
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Gene tandem amplifications can drive bacterial evolution. Here, Belikova et al. identify copy number variations of lipoprotein-encoding genes in Staphylococcus aureus clinical isolates, and show that the loci expand and contract during bacterial grow
Externí odkaz:
https://doaj.org/article/4c383d564aab421693bdf9003b5298d4
Autor:
Lea A. Adolf, Simon Heilbronner
Publikováno v:
Metabolites, Vol 12, Iss 6, p 489 (2022)
The human nasal microbiome can be a reservoir for several pathogens, including Staphylococcus aureus. However, certain harmless nasal commensals can interfere with pathogen colonisation, an ability that could be exploited to prevent infection. Althou
Externí odkaz:
https://doaj.org/article/a1794598902047a181b7790f29e41251
Autor:
Angelika Jochim, Lea Adolf, Darya Belikova, Nadine Anna Schilling, Inda Setyawati, Denny Chin, Severien Meyers, Peter Verhamme, David E Heinrichs, Dirk J Slotboom, Simon Heilbronner
Publikováno v:
eLife, Vol 9 (2020)
Energy-coupling factor type transporters (ECF) represent trace nutrient acquisition systems. Substrate binding components of ECF-transporters are membrane proteins with extraordinary affinity, allowing them to scavenge trace amounts of ligand. A numb
Externí odkaz:
https://doaj.org/article/bb9c21cf2d254f17b1ffa35cbd2f56c1