Zobrazeno 1 - 10
of 192
pro vyhledávání: '"Simon, Heath"'
Autor:
Eva María Trinidad, Antonio Juan-Ribelles, Giulia Pisano, Victoria Castel, Adela Cañete, Marta Gut, Simon Heath, Jaime Font de Mora
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
BackgroundLiquid biopsy has emerged as a promising, non-invasive diagnostic approach in oncology because the analysis of circulating tumor DNA (ctDNA) reflects the precise status of the disease at diagnosis, progression, and response to treatment. DN
Externí odkaz:
https://doaj.org/article/2b105c5048c440a9a185fbfc049b7ae7
Autor:
Anna Esteve-Codina, Thomas P. Hofer, Dorothe Burggraf, Marion S. Heiss-Neumann, Wolfgang Gesierich, Anne Boland, Robert Olaso, Marie-Therese Bihoreau, Jean-Francois Deleuze, Winfried Moeller, Otmar Schmid, María Soler Artigas, Kathrin Renner, Jens M. Hohlfeld, Tobias Welte, Thomas Fuehner, Lukas Jerrentrup, Andreas Rembert Koczulla, Timm Greulich, Antje Prasse, Joachim Müller-Quernheim, Sumit Gupta, Christopher Brightling, Deepak R. Subramanian, David G. Parr, Umme Kolsum, Vandana Gupta, Imre Barta, Balázs Döme, János Strausz, Mariarita Stendardo, Marco Piattella, Piera Boschetto, Damian Korzybski, Dorota Gorecka, Adam Nowinski, Marc Dabad, Marcos Fernández-Callejo, David Endesfelder, Wolfgang zu Castell, Pieter S. Hiemstra, Per Venge, Elfriede Noessner, Thasso Griebel, Simon Heath, Dave Singh, Ivo Gut, Loems Ziegler-Heitbrock
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Chronic obstructive pulmonary disease (COPD) is a destructive inflammatory disease and the genes expressed within the lung are crucial to its pathophysiology. We have determined the RNAseq transcriptome of bronchial brush cells from 312 stri
Externí odkaz:
https://doaj.org/article/910271cd28a0431e890028bbd9684f22
Autor:
Jesús Ogando, María Eugenia Sáez, Javier Santos, Cristina Nuevo-Tapioles, Marta Gut, Anna Esteve-Codina, Simon Heath, Antonio González-Pérez, José M. Cuezva, Rosa Ana Lacalle, Santos Mañes
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-17 (2019)
Abstract Background Binding of the programmed death-1 (PD-1) receptor to its ligands (PD-L1/2) transduces inhibitory signals that promote exhaustion of activated T cells. Blockade of the PD-1 pathway is widely used for cancer treatment, yet the inhib
Externí odkaz:
https://doaj.org/article/bf07bf307d7e439992d5b6c5761a4ede
Autor:
Mohammadali Yavari Ramsheh, PhD, Koirobi Haldar, PhD, Anna Esteve-Codina, PhD, Lillie F Purser, MSc, Matthew Richardson, PhD, Joachim Müller-Quernheim, ProfPhD, Timm Greulich, PhD, Adam Nowinski, PhD, Imre Barta, PhD, Mariarita Stendardo, PhD, Piera Boschetto, PhD, Damian Korzybski, PhD, Antje Prasse, ProfPhD, David G Parr, ProfPhD, Jens M Hohlfeld, PhD, Balázs Döme, PhD, Tobias Welte, ProfPhD, Simon Heath, PhD, Ivo Gut, ProfPhD, Julie A Morrissey, ProfPhD, Loems Ziegler-Heitbrock, ProfPhD, Michael R Barer, ProfPhD, Dave Singh, ProfPhD, Christopher E Brightling, ProfPhD
Publikováno v:
The Lancet Microbe, Vol 2, Iss 7, Pp e300-e310 (2021)
Summary: Background: Chronic obstructive pulmonary disease (COPD) is associated with airway inflammation and bacterial dysbiosis. The relationship between the airway microbiome and bronchial gene expression in COPD is poorly understood. We aimed to i
Externí odkaz:
https://doaj.org/article/c985ceb79a9a457db5ad581bcce60af8
Autor:
Luigi Grassi, Farzin Pourfarzad, Sebastian Ullrich, Angelika Merkel, Felipe Were, Enrique Carrillo-de-Santa-Pau, Guoqiang Yi, Ida H. Hiemstra, Anton T.J. Tool, Erik Mul, Juliane Perner, Eva Janssen-Megens, Kim Berentsen, Hinri Kerstens, Ehsan Habibi, Marta Gut, Marie Laure Yaspo, Matthias Linser, Ernesto Lowy, Avik Datta, Laura Clarke, Paul Flicek, Martin Vingron, Dirk Roos, Timo K. van den Berg, Simon Heath, Daniel Rico, Mattia Frontini, Myrto Kostadima, Ivo Gut, Alfonso Valencia, Willem H. Ouwehand, Hendrik G. Stunnenberg, Joost H.A. Martens, Taco W. Kuijpers
Publikováno v:
Cell Reports, Vol 24, Iss 10, Pp 2784-2794 (2018)
Summary: Neutrophils are short-lived blood cells that play a critical role in host defense against infections. To better comprehend neutrophil functions and their regulation, we provide a complete epigenetic overview, assessing important functional f
Externí odkaz:
https://doaj.org/article/dc462ba47f53441fbc56441e3b97245e
Autor:
Mireia Pedragosa, Graciela Riera, Valentina Casella, Anna Esteve-Codina, Yael Steuerman, Celina Seth, Gennady Bocharov, Simon Heath, Irit Gat-Viks, Jordi Argilaguet, Andreas Meyerhans
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
The host immune response against infection requires the coordinated action of many diverse cell subsets that dynamically adapt to a pathogen threat. Due to the complexity of such a response, most immunological studies have focused on a few genes, pro
Externí odkaz:
https://doaj.org/article/fab34533fb384ae4b44e25c42d44fdde
Autor:
Dirk S. Paul, Andrew E. Teschendorff, Mary A.N. Dang, Robert Lowe, Mohammed I. Hawa, Simone Ecker, Huriya Beyan, Stephanie Cunningham, Alexandra R. Fouts, Anita Ramelius, Frances Burden, Samantha Farrow, Sophia Rowlston, Karola Rehnstrom, Mattia Frontini, Kate Downes, Stephan Busche, Warren A. Cheung, Bing Ge, Marie-Michelle Simon, David Bujold, Tony Kwan, Guillaume Bourque, Avik Datta, Ernesto Lowy, Laura Clarke, Paul Flicek, Emanuele Libertini, Simon Heath, Marta Gut, Ivo G Gut, Willem H. Ouwehand, Tomi Pastinen, Nicole Soranzo, Sabine E. Hofer, Beate Karges, Thomas Meissner, Bernhard O. Boehm, Corrado Cilio, Helena Elding Larsson, Åke Lernmark, Andrea K. Steck, Vardhman K. Rakyan, Stephan Beck, R. David Leslie
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
The incidence of type 1 diabetes is increasing, potentially implicating non-genetic factors. Here the authors conduct an epigenome-wide association study in disease-discordant twins and find increased DNA methylation variability at genes associated w
Externí odkaz:
https://doaj.org/article/74847440186d44ba8513e31e9862b708
Autor:
Benjamin C. Hitz, Jin-Wook Lee, Otto Jolanki, Meenakshi S. Kagda, Keenan Graham, Paul Sud, Idan Gabdank, J. Seth Strattan, Cricket A. Sloan, Timothy Dreszer, Laurence D. Rowe, Nikhil R. Podduturi, Venkat S. Malladi, Esther T. Chan, Jean M. Davidson, Marcus Ho, Stuart Miyasato, Matt Simison, Forrest Tanaka, Yunhai Luo, Ian Whaling, Eurie L. Hong, Brian T. Lee, Richard Sandstrom, Eric Rynes, Jemma Nelson, Andrew Nishida, Alyssa Ingersoll, Michael Buckley, Mark Frerker, Daniel S Kim, Nathan Boley, Diane Trout, Alex Dobin, Sorena Rahmanian, Dana Wyman, Gabriela Balderrama-Gutierrez, Fairlie Reese, Neva C. Durand, Olga Dudchenko, David Weisz, Suhas S. P. Rao, Alyssa Blackburn, Dimos Gkountaroulis, Mahdi Sadr, Moshe Olshansky, Yossi Eliaz, Dat Nguyen, Ivan Bochkov, Muhammad Saad Shamim, Ragini Mahajan, Erez Aiden, Tom Gingeras, Simon Heath, Martin Hirst, W. James Kent, Anshul Kundaje, Ali Mortazavi, Barbara Wold, J. Michael Cherry
The Encyclopedia of DNA elements (ENCODE) project is a collaborative effort to create a comprehensive catalog of functional elements in the human genome. The current database comprises more than 19000 functional genomics experiments across more than
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3ede3b75e1612917e82c16d5ca40cfb
https://doi.org/10.1101/2023.04.04.535623
https://doi.org/10.1101/2023.04.04.535623
Autor:
Eva María Trinidad, Enrique Vidal, Esther Coronado, Anna Esteve-Codina, Victoria Castel, Adela Cañete, Marta Gut, Simon Heath, Jaime Font de Mora
Publikováno v:
Briefings in Bioinformatics. 24
Analysis of the methylome of tumor cell-free deoxyribonucleic acid (DNA; cfDNA) has emerged as a powerful non-invasive technique for cancer subtyping and prognosis. However, its application is frequently hampered by the quality and total cfDNA yield.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c643217c550e110bf92aa916eff3e38e
https://doi.org/10.1093/bib/bbac575
https://doi.org/10.1093/bib/bbac575
Summary: Nanopore reads encode information on the methylation status of cytosines in CpG dinucleotides. The length of the reads makes it comparatively easy to look at patterns consisting of multiple loci; here, we exploit this property to search for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15d9e0df95089f962f7d0f372bf80d8e
http://hdl.handle.net/10230/57257
http://hdl.handle.net/10230/57257