Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Simon, Gravel"'
Autor:
Jennifer Brooks, Anne Hayes, Riaz Alvi, Mahmoud Azimaee, Parveen Bhatti, Sheraz Cheema, Tim Choi, Nouar ElKhair, Megan Fleming, Noah Frank, Katelyn Frizzell, Jodi Gatley, Lindsey Gilbert, Simon Gravel, Shandra Harman, Jason Hicks, Vikki Ho, Jordan Hunt, Stefana Jovanovska, Victoria Kirsh, Robyn Kydd, Carmen La, Kendra Lester, Guillaume Lettre, Magda Nunes De Melo, Mary-Ann Standing, Lindsay Stewart, Donna Turner, Robin Urquhart, Jennifer Vena, Eric Youngson, Philip Awadalla
Publikováno v:
International Journal of Population Data Science, Vol 9, Iss 5 (2024)
Objective To highlight the partnership between the Canadian Partnership for Tomorrow’s Health (CanPath) and Health Data Research Network (HDRN Canada), which enables researchers to link CanPath’s health and lifestyle survey data to health records
Externí odkaz:
https://doaj.org/article/a527fbf0fd644a9ab39ebf37b0a3e5b2
Autor:
Robin Urquhart, Philip Awadalla, Parveen Bhatti, Trevor Dummer, Simon Gravel, Jennifer Vena, Riaz Alvi, Philippe Broet, Cynthia Kendell, Victoria Kirsh, Guillaume Lettre, Kimberly Skead, Grace Shen-Tu, Ellen Sweeney, Donna Turner
Publikováno v:
International Journal of Population Data Science, Vol 7, Iss 3 (2022)
Objectives We will enrich the cancer research ecosystem in Canada through linking cancer registry and administrative health data to the Canadian Partnership for Tomorrow’s Health (CanPath) cohort and biobank. CanPath is Canada’s largest populatio
Externí odkaz:
https://doaj.org/article/4d047db44ccb429c895d3450fa6519ab
Autor:
Luke Anderson-Trocmé, Dominic Nelson, Shadi Zabad, Alex Diaz-Papkovich, Ivan Kryukov, Nikolas Baya, Mathilde Touvier, Ben Jeffery, Christian Dina, Hélène Vézina, Jerome Kelleher, Simon Gravel
Publikováno v:
Science. 380:849-855
Population genetic models only provide coarse representations of real-world ancestry. We used a pedigree compiled from 4 million parish records and genotype data from 2276 French and 20,451 French Canadian individuals to finely model and trace French
Autor:
Melissa L Spear, Alex Diaz-Papkovich, Elad Ziv, Joseph M Yracheta, Simon Gravel, Dara G Torgerson, Ryan D Hernandez
Publikováno v:
eLife, Vol 9 (2020)
People in the Americas represent a diverse continuum of populations with varying degrees of admixture among African, European, and Amerindigenous ancestries. In the United States, populations with non-European ancestry remain understudied, and thus l
Externí odkaz:
https://doaj.org/article/2716df81458047ffa37e18166e17a605
Autor:
Jeffrey R Adrion, Christopher B Cole, Noah Dukler, Jared G Galloway, Ariella L Gladstein, Graham Gower, Christopher C Kyriazis, Aaron P Ragsdale, Georgia Tsambos, Franz Baumdicker, Jedidiah Carlson, Reed A Cartwright, Arun Durvasula, Ilan Gronau, Bernard Y Kim, Patrick McKenzie, Philipp W Messer, Ekaterina Noskova, Diego Ortega-Del Vecchyo, Fernando Racimo, Travis J Struck, Simon Gravel, Ryan N Gutenkunst, Kirk E Lohmueller, Peter L Ralph, Daniel R Schrider, Adam Siepel, Jerome Kelleher, Andrew D Kern
Publikováno v:
eLife, Vol 9 (2020)
The explosion in population genomic data demands ever more complex modes of analysis, and increasingly, these analyses depend on sophisticated simulations. Recent advances in population genetic simulation have made it possible to simulate large and c
Externí odkaz:
https://doaj.org/article/3524c850e8cf4035a0c097b7202a542b
Publikováno v:
PLoS Genetics, Vol 16, Iss 5, p e1008619 (2020)
Coalescent simulations are widely used to examine the effects of evolution and demographic history on the genetic makeup of populations. Thanks to recent progress in algorithms and data structures, simulators such as the widely-used msprime now provi
Externí odkaz:
https://doaj.org/article/35553f55243a41c2a67cfd265944473f
Publikováno v:
PLoS Genetics, Vol 15, Iss 11, p e1008432 (2019)
Human populations feature both discrete and continuous patterns of variation. Current analysis approaches struggle to jointly identify these patterns because of modelling assumptions, mathematical constraints, or numerical challenges. Here we apply u
Externí odkaz:
https://doaj.org/article/875148cd3add40e69c8d1a75f093f093
Autor:
Aaron P Ragsdale, Simon Gravel
Publikováno v:
PLoS Genetics, Vol 15, Iss 6, p e1008204 (2019)
We learn about population history and underlying evolutionary biology through patterns of genetic polymorphism. Many approaches to reconstruct evolutionary histories focus on a limited number of informative statistics describing distributions of alle
Externí odkaz:
https://doaj.org/article/85bc6046c80b432b9e7ce2b24cfe4e05
The recent proliferation of large scale genome-wide association studies (GWASs) has motivated the development of statistical methods for phenotype prediction using single nucleotide polymorphism (SNP) array data. These polygenic risk score (PRS) meth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7f067e07e8f7ecc993f0f9b3ff9f401
https://doi.org/10.1101/2022.05.10.491396
https://doi.org/10.1101/2022.05.10.491396
Autor:
Dan Moldoveanu, LeeAnn Ramsay, Mathieu Lajoie, Luke Anderson-Trocme, Marine Lingrand, Diana Berry, Lucas J.M. Perus, Yuhong Wei, Cleber Moraes, Rached Alkallas, Shivshankari Rajkumar, Dongmei Zuo, Matthew Dankner, Eric Hongbo Xu, Nicholas R. Bertos, Hamed S. Najafabadi, Simon Gravel, Santiago Costantino, Martin J. Richer, Amanda W. Lund, Sonia V. Del Rincon, Alan Spatz, Wilson H. Miller, Rahima Jamal, Réjean Lapointe, Anne-Marie Mes-Masson, Simon Turcotte, Kevin Petrecca, Sinziana Dumitra, Ari-Nareg Meguerditchian, Keith Richardson, Francine Tremblay, Beatrice Wang, May Chergui, Marie-Christine Guiot, Kevin Watters, John Stagg, Daniela F. Quail, Catalin Mihalcioiu, Sarkis Meterissian, Ian R. Watson
Publikováno v:
Science Immunology. 7
Melanoma is an immunogenic cancer with a high response rate to immune checkpoint inhibitors (ICIs). It harbors a high mutation burden compared with other cancers and, as a result, has abundant tumor-infiltrating lymphocytes (TILs) within its microenv