Penicillin-Binding Protein 1 (PBP1) of Staphylococcus aureus Has Multiple Essential Functions in Cell Division

Autor: Katarzyna Wacnik, Vincenzo A. Rao, Xinyue Chen, Lucia Lafage, Manuel Pazos, Simon Booth, Waldemar Vollmer, Jamie K. Hobbs, Richard J. Lewis, Simon J. Foster

Publikováno v: mBio, Vol 13, Iss 4 (2022)

ABSTRACT Bacterial cell division is a complex process requiring the coordination of multiple components to allow the appropriate spatial and temporal control of septum formation and cell scission. Peptidoglycan (PG) is the major structural component

Externí odkaz: https://doaj.org/article/7ea851c91c764329a9c947d3d0339c7f

SPaCE Swab: Point-of-Care Sensor for Simple and Rapid Detection of Acute Wound Infection

Autor: June D. Mercer-Chalmers, Anthony Sack, Simon Booth, Amber Young, A.T.A. Jenkins, Rosemary Greenwood, Karen Coy, Naing Tun Thet

Publikováno v: ACS Sensors

Wound infection is commonly observed after surgery and trauma but is difficult to diagnose and poorly defined in terms of objective clinical parameters. The assumption that bacteria in a wound correlate with infection is false; all wounds contain mic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87cd5c8f660d57ae0039b0055d841599
http://europepmc.org/articles/PMC7460538

Laboratory study to investigate the sensitivity and specificity of a diagnostic dressing to detect burn wound infection

Autor: June D. Mercer-Chalmers, Amber Young, Rosemary Greenwood, Simon Booth, F. Spickett-Jones, Karen Coy, S. Bremner, A.T.A. Jenkins, Naing Tun Thet, Declan Collins

Burn Wound Infection (BWI) is difficult to define and detect before it manifests with clear clinical symptoms. In this paper, an ex vivo study of a prototype BWI detecting wound dressing is reported. Consenting patients with burns were recruited from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e32a1d62f8188d4607bef4586f14f790
https://doi.org/10.1101/2021.07.21.21260922

Structural and functional analyses of glycoside hydrolase 138 enzymes targeting chain A galacturonic acid in the complex pectin rhamnogalacturonan II

Autor: Alan Cartmell, Simon Booth, Robert A. Field, Jose Munoz-Munoz, Didier Ndeh, Arnaud Baslé, Aurore Labourel, Sergey A. Nepogodiev

Publikováno v: Field, R 2019, ' Structural and functional analysis of glycoside hydrolase 138 enzymes targeting chain A galacturonic acid in the complex pectin rhamnogalacturonan II ', Journal of Biological Chemistry, vol. 294, no. 19, 294, pp. 7711–7721 . https://doi.org/10.1074/jbc.ra118.006626
JOURNAL OF BIOLOGICAL CHEMISTRY
J Biol Chem

The metabolism of carbohydrate polymers drives microbial diversity in the human gut microbiome. The selection pressures in this environment have spurred the evolution of a complex reservoir of microbial genes encoding carbohydrate-active enzymes (CAZ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d96ab89f34bd17d68aae8efe5d2cd88a
https://doi.org/10.1074/jbc.ra118.006626

Consensus demonstrates four indicators needed to standardize burn wound infection reporting across trials in a single-country study (ICon-B study)

Autor: Riaz Agha, Karen Marlow, Mamta Shah, Karen Coy, Jo C Dumville, Declan Collins, Simon Booth, L. Teare, Baljit Dheansa, Anna Davies, Luke S. P. Moore, A.T.A. Jenkins, Amber Young, Sian Falder

Publikováno v: Davies, A, Teare, L, Falder, S, Dumville, J, Shah, M, Jenkins, A T A, Collins, D, Dheansa, B, Coy, K, Booth, S, Moore, L, Marlow, K, Agha, R & Young, A 2020, ' Consensus demonstrates four indicators needed to standardize burn wound infection reporting across trials in a single-country study (ICon-B study) ', Journal of Hospital Infection, vol. 106, no. 2, pp. 217-225 . https://doi.org/10.1016/j.jhin.2020.07.022

Summary Introduction Evidence-based interventions are needed to treat burn wound infection (BWI). Evidence syntheses have been limited by heterogeneity of indicators used to report BWI across trials. Consistent reporting of BWI would be facilitated b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11ff684ab8ef2d426dec952e77cbd631
https://pubmed.ncbi.nlm.nih.gov/32763331