Zobrazeno 1 - 10
of 190
pro vyhledávání: '"Simon, Andrews"'
Publikováno v:
F1000Research, Vol 11 (2024)
Background Robust analysis of DNA sequencing data needs to include a set of quality control steps to ensure that technical bias is kept to a minimum. A metric easily obtained is the frequency of each of the nucleobases for each position across all se
Externí odkaz:
https://doaj.org/article/a2ad8c99320c44fcabe5f745012a071f
Autor:
Olga Mielczarek, Carolyn H. Rogers, Yinxiu Zhan, Louise S. Matheson, Michael J.T. Stubbington, Stefan Schoenfelder, Daniel J. Bolland, Biola M. Javierre, Steven W. Wingett, Csilla Várnai, Anne Segonds-Pichon, Simon J. Conn, Felix Krueger, Simon Andrews, Peter Fraser, Luca Giorgetti, Anne E. Corcoran
Publikováno v:
Cell Reports, Vol 42, Iss 9, Pp 113074- (2023)
Summary: To produce a diverse antibody repertoire, immunoglobulin heavy-chain (Igh) loci undergo large-scale alterations in structure to facilitate juxtaposition and recombination of spatially separated variable (VH), diversity (DH), and joining (JH)
Externí odkaz:
https://doaj.org/article/125cbc8ecfba40ce99ab9245a423021d
Autor:
Simon Andrews, Christel Krueger, Maravillas Mellado-Lopez, Myriam Hemberger, Wendy Dean, Vicente Perez-Garcia, Courtney W. Hanna
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
DNA methylation is a repressive modification that is essential for development. Here the authors reveal a critical role for DNA methylation in placental development during pregnancy. Failure to properly establish placental DNA methylation patterns co
Externí odkaz:
https://doaj.org/article/01d5556441ef4bbcbc1a30a3c4fa2e0a
Publikováno v:
F1000Research, Vol 11 (2022)
Background: Robust analysis of DNA sequencing data needs to include a set of quality control steps to ensure that technical bias is kept to a minimum. A metric easily obtained is the frequency of each of the nucleobases for each position across all s
Externí odkaz:
https://doaj.org/article/387e1195872548418cdf2665a36f0bb7
Autor:
Mayra Furlan-Magaril, Masami Ando-Kuri, Rodrigo G. Arzate-Mejía, Jörg Morf, Jonathan Cairns, Abraham Román-Figueroa, Luis Tenorio-Hernández, A. César Poot-Hernández, Simon Andrews, Csilla Várnai, Boo Virk, Steven W. Wingett, Peter Fraser
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-27 (2021)
Abstract Background Circadian gene expression is essential for organisms to adjust their physiology and anticipate daily changes in the environment. The molecular mechanisms controlling circadian gene transcription are still under investigation. In p
Externí odkaz:
https://doaj.org/article/9a210e18686b41e2bfd4786eebcb2e8a
Autor:
Nikola Dolezalova, Anja Gruszczyk, Kerry Barkan, John A. Gamble, Sam Galvin, Till Moreth, Kevin O’Holleran, Krishnaa T. Mahbubani, Jackie A. Higgins, Fiona M. Gribble, Frank Reimann, Jakub Surmacki, Simon Andrews, John J. Casey, Francesco Pampaloni, Michael P. Murphy, Graham Ladds, Nigel K. H. Slater, Kourosh Saeb-Parsy
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
Abstract Cryopreservation offers the potential to increase the availability of pancreatic islets for treatment of diabetic patients. However, current protocols, which use dimethyl sulfoxide (DMSO), lead to poor cryosurvival of islets. We demonstrate
Externí odkaz:
https://doaj.org/article/b718aa2f9b114fbdad8edf4f86a67ef9
Autor:
John A. Halsall, Simon Andrews, Felix Krueger, Charlotte E. Rutledge, Gabriella Ficz, Wolf Reik, Bryan M. Turner
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-19 (2021)
Abstract Chromatin configuration influences gene expression in eukaryotes at multiple levels, from individual nucleosomes to chromatin domains several Mb long. Post-translational modifications (PTM) of core histones seem to be involved in chromatin s
Externí odkaz:
https://doaj.org/article/638296035c4644d5b4cc65f25c7d7cda
Autor:
Oliver Thompson, Ferdinand von Meyenn, Zoe Hewitt, John Alexander, Andrew Wood, Richard Weightman, Sian Gregory, Felix Krueger, Simon Andrews, Ivana Barbaric, Paul J. Gokhale, Harry D. Moore, Wolf Reik, Marta Milo, Serena Nik-Zainal, Kosuke Yusa, Peter W. Andrews
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Mutations in human pluripotent stem cells (PSC) and whether any form during culture prior to use in a human clinical context are a concern. Here, the authors use hPSCs derived to cGMP standards and show they have low mutation rates after culture, not
Externí odkaz:
https://doaj.org/article/6f55e007701f4013b3a7b971436b8888
Autor:
Manusnan Suriyalaksh, Celia Raimondi, Abraham Mains, Anne Segonds-Pichon, Shahzabe Mukhtar, Sharlene Murdoch, Rebeca Aldunate, Felix Krueger, Roger Guimerà, Simon Andrews, Marta Sales-Pardo, Olivia Casanueva
Publikováno v:
iScience, Vol 25, Iss 1, Pp 103663- (2022)
Summary: We design a “wisdom-of-the-crowds” GRN inference pipeline and couple it to complex network analysis to understand the organizational principles governing gene regulation in long-lived glp-1/Notch Caenorhabditis elegans. The GRN has three
Externí odkaz:
https://doaj.org/article/d7864594db424057aaddbda6be37f21a
Autor:
Hannah Demond, Zahra Anvar, Bahia Namavar Jahromi, Angela Sparago, Ankit Verma, Maryam Davari, Luciano Calzari, Silvia Russo, Mojgan Akbarzadeh Jahromi, David Monk, Simon Andrews, Andrea Riccio, Gavin Kelsey
Publikováno v:
Genome Medicine, Vol 11, Iss 1, Pp 1-14 (2019)
Abstract Background Maternal effect mutations in the components of the subcortical maternal complex (SCMC) of the human oocyte can cause early embryonic failure, gestational abnormalities and recurrent pregnancy loss. Enigmatically, they are also ass
Externí odkaz:
https://doaj.org/article/ae793ee5365c48e3b148901a193e9c00