A Transversal Approach Combining In Silico, In Vitro and In Vivo Models to Describe the Metabolism of the Receptor Interacting Protein 1 Kinase Inhibitor Sibiriline.

Autor: Pelletier, Romain, Gicquel, Thomas, Simoes Eugenio, Mélanie, Ferron, Pierre-Jean, Morel, Isabelle, Delehouzé, Claire, Dimanche-Boitrel, Marie-Thérèse, Rousselot, Morgane, Le Daré, Brendan

Publikováno v: Pharmaceutics; Dec2022, Vol. 14 Issue 12, p2665, 15p

Establishment and study of murine models of NASH progression until HCC development : effect of hyperlipidic diet on the hepatic environment

Autor: Simoes Eugenio, Mélanie

Publikováno v: Médecine humaine et pathologie. Université Rennes 1, 2019. Français. ⟨NNT : 2019REN1B072⟩
Médecine humaine et pathologie. Université de Rennes, 2019. Français. ⟨NNT : 2019REN1B072⟩

Representing more than 85% of the cases, hepatocellular carcinoma (HCC) is the most common type of primary liver cancer and, with over 750,000 deaths per year, is the 4th leading cause of cancer-related death. In the past few years, an important incr

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