Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Simo Schwartz"'
Autor:
Higinio Dopeso, Paulo Rodrigues, Fernando Cartón-García, Irati Macaya, Josipa Bilic, Estefanía Anguita, Li Jing, Bruno Brotons, Núria Vivancos, Laia Beà, Manuel Sánchez-Martín, Stefania Landolfi, Javier Hernandez-Losa, Santiago Ramon y Cajal, Rocío Nieto, María Vicario, Ricard Farre, Simo Schwartz, Jr., Sven C.D. van Ijzendoorn, Kazuto Kobayashi, Águeda Martinez-Barriocanal, Diego Arango
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109400- (2024)
Summary: Rho GTPases are molecular switches regulating multiple cellular processes. To investigate the role of RhoA in normal intestinal physiology, we used a conditional mouse model overexpressing a dominant negative RhoA mutant (RhoAT19N) in the in
Externí odkaz:
https://doaj.org/article/9d852163178f465ea052ec089ed5a27d
Autor:
Mar Gil, Lareen Khouri, Imma Raurell, Diana Rafael, Fernanda Andrade, Ibane Abasolo, Simo Schwartz, María Martínez-Gómez, María Teresa Salcedo, Juan Manuel Pericàs, Diana Hide, Mingxing Wei, Norman Metanis, Joan Genescà, María Martell
Publikováno v:
Pharmaceutics, Vol 15, Iss 10, p 2463 (2023)
In this study, we developed functionalized polymeric micelles (FPMs) loaded with simvastatin (FPM-Sim) as a drug delivery system to target liver sinusoidal endothelial cells (LSECs) for preserving liver function in chronic liver disease (CLD). Polyme
Externí odkaz:
https://doaj.org/article/e603b3eed6d04f5284bf5147d9e90211
Autor:
Diana Rafael, Marcelo Guerrero, Adolfo Marican, Diego Arango, Bruno Sarmento, Roser Ferrer, Esteban F. Durán-Lara, Simon J. Clark, Simo Schwartz
Publikováno v:
Pharmaceutics, Vol 15, Iss 5, p 1484 (2023)
Slow-release delivery systems are needed to ensure long-term sustained treatments for retinal diseases such as age-related macular degeneration and diabetic retinopathy, which are currently treated with anti-angiogenic agents that require frequent in
Externí odkaz:
https://doaj.org/article/54122d48dbdd4939bc52a5a5f7edf6e0
Autor:
Manuel Galiñanes, Kelly Casós, Arnau Blasco-Lucas, Eduard Permanyer, Rafael Máñez, Thierry Le Tourneau, Jordi Barquinero, Simo Schwartz, Tomaso Bottio, Jean Christian Roussel, Imen Fellah-Hebia, Thomas Sénage, Arturo Evangelista, Luigi P. Badano, Alejandro Ruiz-Majoral, Cesare Galli, Vered Padler-Karavani, Jean-Paul Soulillou, Xavier Vidal, Emanuele Cozzi, Cristina Costa
Publikováno v:
Biomolecules, Vol 12, Iss 11, p 1606 (2022)
The cause of structural valve deterioration (SVD) is unclear. Therefore, we investigated oxidative stress markers in sera from patients with bioprosthetic heart valves (BHVs) and their association with SVD. Blood samples were taken from SVD (Phase A)
Externí odkaz:
https://doaj.org/article/722a6f5b2f424ca9a7df24370ed26755
Autor:
Laia Hernandez-Oller, Joaquin Seras-Franzoso, Fernanda Andrade, Diana Rafael, Ibane Abasolo, Petra Gener, Simo Schwartz Jr.
Publikováno v:
Pharmaceutics, Vol 12, Iss 12, p 1146 (2020)
Within tumors, Cancer Stem Cell (CSC) subpopulation has an important role in maintaining growth and dissemination while preserving high resistance against current treatments. It has been shown that, when CSCs are eliminated, the surrounding Different
Externí odkaz:
https://doaj.org/article/0339bf81df4d4515934fb1ae89483aff
Autor:
Sara Montero, Joaquin Seras-Franzoso, Fernanda Andrade, Francesc Martinez-Trucharte, Mireia Vilar-Hernández, Manuel Quesada, Helena Xandri, Diego Arango, Ibane Abasolo, Diana Rafael, Simo Schwartz
Publikováno v:
Pharmaceutics, Vol 12, Iss 2, p 185 (2020)
Structural maintenance of chromosomes protein 2 (SMC2) is a central component of the condensin complex involved in DNA supercoiling, an essential process for embryonic stem cell survival. SMC2 over-expression has been related with tumorigenesis and c
Externí odkaz:
https://doaj.org/article/b622e52b18ce44d4ba9955ecd7298334
Autor:
Renuka Kandhaya-Pillai, Francesc Miro-Mur, Jaume Alijotas-Reig, Tamar Tchkonia, Simo Schwartz, James L. Kirkland, Junko Oshima
Publikováno v:
Aging.
Autor:
Diego Arango, Simo Schwartz, Josep Tabernero, Santiago Ramon y Cajal, John M. Mariadason, Andrew J. Wilson, Manel Armengol, Eloy Espín, Maria Josep Carreras, Sarah Bazzocco, Paulo Rodrigues, Rocco Mazzolini, Javier Hernández-Losa, Francisco Javier Ramos Pascual, Stefania Landolfi, Elena Elez, Silvia Mateo-Lozano, Higinio Dopeso
Supplementary Data from Aprataxin Tumor Levels Predict Response of Colorectal Cancer Patients to Irinotecan-based Treatment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30f9ca1eaaa26581255d53796f7b0d51
https://doi.org/10.1158/1078-0432.22442343
https://doi.org/10.1158/1078-0432.22442343
Autor:
Diego Arango, Lauri A. Aaltonen, Simo Schwartz, Jukka-Pekka Mecklin, Heikki Järvinen, Akseli Hemminki, Reijo Salovaara, Verónica Dávalos, Heli Sammalkorpi, Hafid Alazzouzi, Pia Alhopuro
We have recently reported that low tumor levels of SMAD4, a key mediator of transforming growth factor-β superfamily signaling, can predict the probability of recurrence in patients with Dukes C colorectal cancer who had surgery as the only form of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::027b1cb41f644debef36d58d4ea2eb0e
https://doi.org/10.1158/1078-0432.c.6518116.v1
https://doi.org/10.1158/1078-0432.c.6518116.v1
Autor:
Diego Arango, Lauri A. Aaltonen, Simo Schwartz, Jukka-Pekka Mecklin, Heikki Järvinen, Akseli Hemminki, Reijo Salovaara, Verónica Dávalos, Heli Sammalkorpi, Hafid Alazzouzi, Pia Alhopuro
Supplementary Tables S1 & S2 and Figure S1 from SMAD4 Levels and Response to 5-Fluorouracil in Colorectal Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78302947799760b9baa202d2d48a00ab
https://doi.org/10.1158/1078-0432.22440853.v1
https://doi.org/10.1158/1078-0432.22440853.v1