Alzheimer's disease as an autoimmune disorder of innate immunity endogenously modulated by tryptophan metabolites.

Autor: Meier-Stephenson FS; Department of Chemistry Dalhousie University Halifax Nova Scotia Canada., Meier-Stephenson VC; Department of Chemistry Dalhousie University Halifax Nova Scotia Canada., Carter MD; Department of Chemistry Dalhousie University Halifax Nova Scotia Canada.; Department of Pathology Dalhousie University Halifax Nova Scotia Canada., Meek AR; Department of Chemistry Dalhousie University Halifax Nova Scotia Canada.; Krembil Research Institute University Health Network Toronto Ontario Canada., Wang Y; Department of Chemistry Dalhousie University Halifax Nova Scotia Canada.; Krembil Research Institute University Health Network Toronto Ontario Canada., Pan L; Krembil Research Institute University Health Network Toronto Ontario Canada., Chen Q; Department of Chemistry Dalhousie University Halifax Nova Scotia Canada., Jacobo S; Department of Chemistry Dalhousie University Halifax Nova Scotia Canada., Wu F; Department of Chemistry Dalhousie University Halifax Nova Scotia Canada.; Krembil Research Institute University Health Network Toronto Ontario Canada., Lu E; Department of Chemistry Dalhousie University Halifax Nova Scotia Canada.; Krembil Research Institute University Health Network Toronto Ontario Canada., Simms GA; Department of Chemistry Dalhousie University Halifax Nova Scotia Canada., Fisher L; Department of Chemistry Dalhousie University Halifax Nova Scotia Canada., McGrath AJ; Department of Chemistry Dalhousie University Halifax Nova Scotia Canada., Fermo V; Department of Chemistry Dalhousie University Halifax Nova Scotia Canada., Barden CJ; Department of Chemistry Dalhousie University Halifax Nova Scotia Canada.; Krembil Research Institute University Health Network Toronto Ontario Canada., Clair HDS; Department of Chemistry Dalhousie University Halifax Nova Scotia Canada., Galloway TN; Department of Chemistry Dalhousie University Halifax Nova Scotia Canada., Yadav A; Department of Chemistry Dalhousie University Halifax Nova Scotia Canada.; Krembil Research Institute University Health Network Toronto Ontario Canada., Campágna-Slater V; Department of Chemistry Dalhousie University Halifax Nova Scotia Canada., Hadden M; Department of Chemistry Queen's University Kingston Ontario Canada., Reed M; Department of Chemistry Dalhousie University Halifax Nova Scotia Canada.; Krembil Research Institute University Health Network Toronto Ontario Canada., Taylor M; Department of Chemistry Dalhousie University Halifax Nova Scotia Canada.; Krembil Research Institute University Health Network Toronto Ontario Canada., Kelly B; Krembil Research Institute University Health Network Toronto Ontario Canada., Diez-Cecilia E; Krembil Research Institute University Health Network Toronto Ontario Canada., Kolaj I; Krembil Research Institute University Health Network Toronto Ontario Canada., Santos C; Krembil Research Institute University Health Network Toronto Ontario Canada., Liyanage I; Krembil Research Institute University Health Network Toronto Ontario Canada., Sweeting B; Krembil Research Institute University Health Network Toronto Ontario Canada., Stafford P; Krembil Research Institute University Health Network Toronto Ontario Canada., Boudreau R; Department of Chemistry Dalhousie University Halifax Nova Scotia Canada., Reid GA; Department of Medical Neuroscience Dalhousie University Halifax Nova Scotia Canada., Noyce RS; Department of Microbiology and Immunology Dalhousie University Halifax Nova Scotia Canada., Stevens L; Department of Psychology Dalhousie University Halifax Nova Scotia Canada., Staniszewski A; Taub Institute for Research on Alzheimer's Disease and the Aging Brain & Department of Pathology and Cell Biology Columbia University New York New York USA., Zhang H; Taub Institute for Research on Alzheimer's Disease and the Aging Brain & Department of Pathology and Cell Biology Columbia University New York New York USA., Murty MRVS; Department of Chemistry University of Liège, Allée de la Chimie, Sart-Tilman Liège Belgium., Lemaire P; Department of Chemistry University of Liège, Allée de la Chimie, Sart-Tilman Liège Belgium., Chardonnet S; Department of Chemistry University of Liège, Allée de la Chimie, Sart-Tilman Liège Belgium., Richardson CD; Department of Microbiology and Immunology Dalhousie University Halifax Nova Scotia Canada., Gabelica V; Department of Chemistry University of Liège, Allée de la Chimie, Sart-Tilman Liège Belgium., DePauw E; Department of Chemistry University of Liège, Allée de la Chimie, Sart-Tilman Liège Belgium., Brown R; Department of Psychology Dalhousie University Halifax Nova Scotia Canada., Darvesh S; Department of Medical Neuroscience Dalhousie University Halifax Nova Scotia Canada.; Division of Neurology Department of Medicine Dalhousie University Halifax Nova Scotia Canada., Arancio O; Taub Institute for Research on Alzheimer's Disease and the Aging Brain & Department of Pathology and Cell Biology Columbia University New York New York USA., Weaver DF; Department of Chemistry Dalhousie University Halifax Nova Scotia Canada.; Krembil Research Institute University Health Network Toronto Ontario Canada.; Division of Neurology Department of Medicine Dalhousie University Halifax Nova Scotia Canada.; Department of Pharmaceutical Sciences University of Toronto Toronto Ontario Canada.; Department of Chemistry University of Toronto Toronto Ontario Canada.; Division of Neurology Department of Medicine University of Toronto Toronto Ontario Canada.

Publikováno v: Alzheimer's & dementia (New York, N. Y.) [Alzheimers Dement (N Y)] 2022 Apr 06; Vol. 8 (1), pp. e12283. Date of Electronic Publication: 2022 Apr 06 (Print Publication: 2022).

Searching for an endogenous anti-Alzheimer molecule: identifying small molecules in the brain that slow Alzheimer disease progression by inhibition of ß-amyloid aggregation.

Autor: Meek AR; Department of Chemistry, Dalhousie University, Halifax, NS, Canada., Simms GA, Weaver DF

Publikováno v: Journal of psychiatry & neuroscience : JPN [J Psychiatry Neurosci] 2013 Jul; Vol. 38 (4), pp. 269-75.

The development of new therapeutics for Alzheimer's disease.

Autor: Carter MD; Department of Chemistry, Dalhousie University, Halifax, Nova Scotia, Canada., Simms GA, Weaver DF

Publikováno v: Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2010 Oct; Vol. 88 (4), pp. 475-86. Date of Electronic Publication: 2010 Sep 01.