A TrkB and TrkC partial agonist restores deficits in synaptic function and promotes activity-dependent synaptic and microglial transcriptomic changes in a late-stage Alzheimer's mouse model.

Autor: Latif-Hernandez A; Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA., Yang T; Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA., Butler RR 3rd; Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA., Losada PM; Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, California, USA., Minhas PS; Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA., White H; Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA., Tran KC; Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA., Liu H; Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA., Simmons DA; Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA., Langness V; Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA., Andreasson KI; Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, California, USA.; Chan Zuckerberg Biohub, San Francisco, California, USA., Wyss-Coray T; Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, California, USA.; The Phil and Penny Knight Initiative for Brain Resilience, Stanford University, Stanford, California, USA., Longo FM; Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, California, USA.

Publikováno v: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2024 Jul; Vol. 20 (7), pp. 4434-4460. Date of Electronic Publication: 2024 May 23.

Pharmacological Co-Activation of TrkB and TrkC Receptor Signaling Ameliorates Striatal Neuropathology and Motor Deficits in Mouse Models of Huntington's Disease.

Autor: Simmons DA; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA., Belichenko NP; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA., Longo FM; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.

Publikováno v: Journal of Huntington's disease [J Huntingtons Dis] 2023; Vol. 12 (3), pp. 215-239.

Neuroimaging, Urinary, and Plasma Biomarkers of Treatment Response in Huntington's Disease: Preclinical Evidence with the p75 ^NTR Ligand LM11A-31.

Autor: Simmons DA; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, 94305, USA. simmons3@stanford.edu., Mills BD; Department of Radiology, Stanford University Medical Center, Stanford, CA, 94305, USA., Butler Iii RR; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, 94305, USA., Kuan J; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, 94305, USA., McHugh TLM; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, 94305, USA., Akers C; Department of Radiology, Stanford University Medical Center, Stanford, CA, 94305, USA., Zhou J; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, 94305, USA., Syriani W; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, 94305, USA., Grouban M; Department of Radiology, Stanford University Medical Center, Stanford, CA, 94305, USA., Zeineh M; Department of Radiology, Stanford University Medical Center, Stanford, CA, 94305, USA., Longo FM; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, 94305, USA.

Publikováno v: Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics [Neurotherapeutics] 2021 Apr; Vol. 18 (2), pp. 1039-1063. Date of Electronic Publication: 2021 Mar 30.

Exercise-conditioned plasma ameliorates postoperative cognitive dysfunction by activating hippocampal cholinergic circuit and enhancing BDNF/TrkB signaling.

Autor: Lu, Xiaodi¹ (AUTHOR), Xiong, Weijie² (AUTHOR), Chen, Zhuo¹ (AUTHOR), Li, Yurou² (AUTHOR), Xu, Fengyan² (AUTHOR), Yang, Xue² (AUTHOR), Long, Meiwen² (AUTHOR), Guo, Wenhan² (AUTHOR), Wu, Shuliang² (AUTHOR) wushuliang@ems.hrbmu.edu.cn, Sun, Liang² (AUTHOR) sunliang@hrbmu.edu.cn, Wang, Guonian³ (AUTHOR) wangguonian609cn@aliyun.com

Publikováno v: Cell Communication & Signaling. 11/18/2024, Vol. 22 Issue 1, p1-30. 30p.

Current views on mechanisms of the FLASH effect in cancer radiotherapy.

Autor: Ma, Yuqi¹ (AUTHOR), Zhang, Wenkang¹ (AUTHOR), Zhao, Ziming¹ (AUTHOR), Lv, Jianfeng¹ (AUTHOR), Chen, Junyi¹ (AUTHOR), Yan, Xueqin¹ (AUTHOR), Lin, XiaoJi² (AUTHOR), Zhang, Junlong³ (AUTHOR), Wang, Bingwu³ (AUTHOR), Gao, Song^3,4 (AUTHOR), Xiao, Jie⁵ (AUTHOR) 15110291500@163.com, Yang, Gen¹ (AUTHOR) gen.yang@pku.edu.cn

Publikováno v: National Science Review. Oct2024, Vol. 11 Issue 10, p1-16. 16p.