CCN4 (WISP-1) reduces apoptosis and atherosclerotic plaque burden in an ApoE mouse model

Autor: Williams, Helen, Simmonds, Steven, Bond, Andrew, Somos, Alexandros, Li, Ze, Forbes, Tessa, Bianco, Rosaria, Dugdale, Celyn, Brown, Zoe, Rice, Helen, Herman, Andrew, Johnson, Jason, George, Sarah

Publikováno v: In Atherosclerosis October 2024 397

Mural cell dysfunction promotes coronary blood vessel remodelling and contributes to diastolic dysfunction in mice

Autor: Grootaert, Mandy, Pasut, Alessandra, Raman, Jana, Simmonds, Steven, Col, Umare, Hamdani, Nazha, Carmeliet, Peter, Heymans, Stephane, Jones, Elizabeth

Publikováno v: In Atherosclerosis August 2024 395 Supplement 1

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Aneurysm Severity is Increased by Combined Mmp-7 Deletion and N-cadherin Mimetic (EC4-Fc) Over-Expression

Autor: Lyon, Cressida, Williams, Helen, Bianco, Rosaria, Simmonds, Steven, Brown, Bethan, Wadey, Kerry, Smith, Frank, Johnson, Jason, George, Sarah

Publikováno v: Lyon, C, Williams, H, Bianco, R, Simmonds, S, Brown, B, Wadey, K, Smith, F, Johnson, J & George, S 2017, ' Aneurysm Severity is Increased by Combined Mmp-7 Deletion and N-cadherin Mimetic (EC4-Fc) Over-Expression ', Scientific Reports, vol. 7, 17342 . https://doi.org/10.1038/s41598-017-17700-8

There is an unmet need for treatments to reduce abdominal aortic aneurysm (AAA) progression. Vascular smooth muscle cell (VSMC) apoptosis precipitates AAA formation, whereas VSMC proliferation repairs the vessel wall. We previously demonstrated that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2642::90abdb290f62d3c08231f98ad0be00e5
https://research-information.bris.ac.uk/en/publications/dc016203-6b07-4b8e-ae49-91adc5976395