Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Siming Yuan"'
Autor:
Shiqi Wang, Siming Yuan
Publikováno v:
Frontiers in Pediatrics, Vol 12 (2024)
Congenital lipomatous overgrowth, vascular malformations, epidermal nevi, and skeletal anomalies (CLOVES) constitute a rare overgrowth disorder resulting from a mosaic function-acquiring mutation in the PIK3CA gene. Targeted drugs for the PI3K-AKT si
Externí odkaz:
https://doaj.org/article/6cb9948a4654443cba7ef7acf4228d28
Autor:
Tiantian Fang, Wanbiao Chen, Yaping Sheng, Siming Yuan, Qiaowei Tang, Gongyu Li, Guangming Huang, Jihu Su, Xuan Zhang, Jianye Zang, Yangzhong Liu
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-8 (2019)
Tetrathiomolybdate (TM) and Cu-ATPases, e.g. Wilson (WLN) protein, affect the efficacy of common anticancer drug cisplatin. Here, the authors show that TM generates a protein dimer with a WLN domain by expelling copper and provide insight into the sy
Externí odkaz:
https://doaj.org/article/eb788873ae41467b98ebc2094c4d5779
Publikováno v:
Inorganic Chemistry Frontiers. 9:3820-3827
Cu(i) can substitute Zn(ii) in the RING-domain of RNF11, which perturbs the protein structure, disrupts protein complexes, and interferes with transcriptional regulation of RNF11 in cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34b888bdab33750a35a6c79709d7be5b
https://doi.org/10.1039/d2qi00631f
https://doi.org/10.1039/d2qi00631f
Publikováno v:
Metallomics. 15
Protein reactions play important roles in the mechanism of action of cisplatin. In this work, we found that cisplatin is highly reactive to the RING finger domain of RNF11, a key protein involved in tumorigenesis and metastasis. The results show that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58a278ec38bdae94b7f02212fac0ac11
https://doi.org/10.1093/mtomcs/mfad017
https://doi.org/10.1093/mtomcs/mfad017
Autor:
Kaiming Cao, Yang Zhu, Zhuanghao Hou, Manman Liu, Yanyan Yang, Hongze Hu, Yi Dai, Yu Wang, Siming Yuan, Guangming Huang, Jiaming Mei, Peter J. Sadler, Yangzhong Liu
Publikováno v:
Angewandte Chemie. 135
The unique thermodynamic and kinetic coordination chemistry of ruthenium allows it to modulate key adverse aggregation and membrane interactions of α-synuclein (α-syn) associated with Parkinson's disease. We show that the low-toxic Ru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cd1fd3c89f84aefdf6713ad142a655b
https://doi.org/10.1002/ange.202215360
https://doi.org/10.1002/ange.202215360
Autor:
Zhuanghao Hou, Moujun Luan, Liujuan Zhan, Xinchen Wang, Siming Yuan, Kaiming Cao, Yaping Sheng, Hao Yin, Yangzhong Liu, Guangming Huang
Publikováno v:
Analytical chemistry. 94(40)
Native mass spectrometry, which takes a high concentration of ammonium acetate (NHsub4/subOAc) for ionization, coupled with tedious and solvent-consuming purification, which separates proteins from complicated environments, has shown great potential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98d08efe8458041970e157ea8dcd0945
https://pubmed.ncbi.nlm.nih.gov/36184850
https://pubmed.ncbi.nlm.nih.gov/36184850
Publikováno v:
Chemical Communications. 57:5298-5301
NCp7 protein binds the duplex/quadruplex hybrid structure, which decreases the thermal stability of DNA and unfolds the G-quadruplex structure. Interestingly, the duplex in the stem-loop region is the more favorable binding site of NCp7. The NCp7 bin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b77224070465bf58e98086e99cff8f7
https://doi.org/10.1039/d1cc01767e
https://doi.org/10.1039/d1cc01767e
Publikováno v:
Analytica Chimica Acta. 1141:120-126
Investigation of protein-ligand interactions in physiological conditions is crucial for better understanding of biochemistry because the binding stoichiometry and conformations of complexes in biological processes, such as various types of regulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::457198bad5820e59f23b7c01dd27685d
https://doi.org/10.1016/j.aca.2020.10.036
https://doi.org/10.1016/j.aca.2020.10.036
Publikováno v:
ICASSP 2022 - 2022 IEEE International Conference on Acoustics, Speech and Signal Processing (ICASSP).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::858cd7e51421a2d98f11a39d7f76a401
https://doi.org/10.1109/icassp43922.2022.9747248
https://doi.org/10.1109/icassp43922.2022.9747248
Publikováno v:
Chemical Communications. 56:1397-1400
NAMI-A is highly reactive to Sp1, a tumor metastasis related protein, resulting in the perturbation of the protein structure and disruption of the DNA recognition of Sp1. Interestingly, Sp1 is more susceptible than other zinc finger proteins to NAMI-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9720f7a029790b7f566ed74ccbfebfe
https://doi.org/10.1039/c9cc08775c
https://doi.org/10.1039/c9cc08775c