Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Simi Elizabeth George"'
Publikováno v:
PLoS ONE, Vol 5, Iss 2, p e9374 (2010)
Drosophila body wall muscles are multinucleated syncytia formed by successive fusions between a founder myoblast and several fusion competent myoblasts. Initial fusion gives rise to a bi/trinucleate precursor followed by more fusion cycles forming a
Externí odkaz:
https://doaj.org/article/a7fdfcaf9ec540e38d50e635c5d3bb6a
Autor:
Shirish Shenolikar, Mahmood Ahmed, Simi Elizabeth George, Jeyapriya Rajameenakshi Sundaram, Sujoy Ghosh, Yilong Wu, Irene Chengjie Lee, Sashi Kesavapany, Monalisa Hota, Eng-King Tan
Publikováno v:
ACS Chemical Neuroscience. 10:3575-3589
Guanabenz (GBZ), an α2-adrenergic agonist, demonstrated off-target effects that restored protein homeostasis and ameliorated pathobiology in experimental models of neurodegenerative disease. However, GBZ did not directly activate the integrated stre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b186c494663a8bb70013982a33a24ee
https://doi.org/10.1021/acschemneuro.9b00185
https://doi.org/10.1021/acschemneuro.9b00185
Autor:
Susan B. Gurley, Sujoy Ghosh, Rashidah Binte Sakban, Kengo Azushima, Stacy A. Johnson, Timothy W. Meyer, Thomas M. Coffman, Momoe Maeda, Simi Elizabeth George
Publikováno v:
Diabetes. 67:2096-2106
Diabetic nephropathy (DN) is a leading cause of end-stage renal disease worldwide, but its molecular pathogenesis is not well defined, and there are no specific treatments. In humans, there is a strong genetic component determining susceptibility to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7f550b8baa224bd692c93cc64f33727
https://doi.org/10.2337/db17-1323
https://doi.org/10.2337/db17-1323
Autor:
Shirish Shenolikar, Simi Elizabeth George, Karen Ka Lam Pang, Xue Yan Ho, Permeen Yusoff, Weiwei Luo, Irene Chengjie Lee, Jeyapriya Rajameenakshi Sundaram, Catherine Wenhui Goh, Newman Siu Kwan Sze
Publikováno v:
Cell Death & Differentiation. 25:255-267
Phosphorylation of the eukaryotic translation initiation factor, eIF2α, by stress-activated protein kinases and dephosphorylation by the growth arrest and DNA damage-inducible protein (GADD34)-containing phosphatase is a central node in the integrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38c4eeb45edf90d5f691d61a948891bb
https://doi.org/10.1038/cdd.2017.152
https://doi.org/10.1038/cdd.2017.152
Autor:
Simi Elizabeth George, David W. Reid, Qiang Chen, Christopher V. Nicchitta, Irene Lee, Jeyapriya R. Sundaram, Angeline S.-L. Tay, Shirish Shenolikar
Publikováno v:
Molecular and Cellular Biology. 36:1868-1880
Phosphorylation of eukaryotic initiation factor 2α (eIF2α) controls transcriptome-wide changes in mRNA translation in stressed cells. While phosphorylated eIF2α (P-eIF2α) attenuates global protein synthesis, mRNAs encoding stress proteins are mor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a27b1842b2c72219efc19a0a096d6bf
https://doi.org/10.1128/mcb.00190-16
https://doi.org/10.1128/mcb.00190-16
Autor:
Jeyapriya Rajameenakshi Sundaram, Yilong Wu, Irene Cheng Jie Lee, Simi Elizabeth George, Monalisa Hota, Sujoy Ghosh, Sashi Kesavapany, Mahmood Ahmed, Shirish Shenolikar
Publikováno v:
SSRN Electronic Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df57154c174a5deb47a498e3c213ddb4
https://doi.org/10.2139/ssrn.3279414
https://doi.org/10.2139/ssrn.3279414
Autor:
Matthew H. Brush, Newman Siu Kwan Sze, Catherine Wenhui Goh, Irene Chengjie Lee, Permeen Yusoff, Simi Elizabeth George, Jeyapriya Rajameenakshi Sundaram, Shirish Shenolikar
Publikováno v:
The Journal of biological chemistry. 293(1)
Oxidative and endoplasmic reticulum (ER) stresses are hallmarks of the pathophysiology of ALS and other neurodegenerative diseases. In these stresses, different kinases phosphorylate eukaryotic initiation factor eIF2α, enabling the translation of st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dc71fcc93f810b092211ed88a002422
https://pubmed.ncbi.nlm.nih.gov/29109149
https://pubmed.ncbi.nlm.nih.gov/29109149
Publikováno v:
Journal of cell science. 123(Pt 16)
Skeletal muscles arise by cellular differentiation and regulated gene expression. Terminal differentiation programmes such as muscle growth, extension and attachment to the epidermis, lead to maturation of the muscles. These events require changes in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2d7e7c34f98686362940b52ac8bc611
https://pubmed.ncbi.nlm.nih.gov/20647374
https://pubmed.ncbi.nlm.nih.gov/20647374